SLC7A5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_0015821Biological processmethionine transport
GO_0015823Biological processphenylalanine transport
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0010629Biological processnegative regulation of gene expression
GO_1903577Biological processcellular response to L-arginine
GO_0070327Biological processthyroid hormone transport
GO_0060252Biological processpositive regulation of glial cell proliferation
GO_0150104Biological processtransport across blood-brain barrier
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0032328Biological processalanine transport
GO_0014850Biological processresponse to muscle activity
GO_0015818Biological processisoleucine transport
GO_0042908Biological processxenobiotic transport
GO_0015804Biological processneutral amino acid transport
GO_0089718Biological processamino acid import across plasma membrane
GO_0055093Biological processresponse to hyperoxia
GO_0097421Biological processliver regeneration
GO_0015829Biological processvaline transport
GO_1905534Biological processpositive regulation of L-leucine import across plasma membrane
GO_0003333Biological processamino acid transmembrane transport
GO_1904556Biological processL-tryptophan transmembrane transport
GO_0010507Biological processnegative regulation of autophagy
GO_0015824Biological processproline transport
GO_0015828Biological processtyrosine transport
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032729Biological processpositive regulation of type II interferon production
GO_1902024Biological processL-histidine transport
GO_1905460Biological processnegative regulation of vascular associated smooth muscle cell apoptotic process
GO_1903801Biological processL-leucine import across plasma membrane
GO_0015827Biological processtryptophan transport
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0015820Biological processL-leucine transport
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031528Cellular componentmicrovillus membrane
GO_0070062Cellular componentextracellular exosome
GO_0009925Cellular componentbasal plasma membrane
GO_0098591Cellular componentexternal side of apical plasma membrane
GO_1990184Cellular componentamino acid transport complex
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005765Cellular componentlysosomal membrane
GO_0015171Molecular functionamino acid transmembrane transporter activity
GO_0015179Molecular functionL-amino acid transmembrane transporter activity
GO_0015349Molecular functionthyroid hormone transmembrane transporter activity
GO_0015196Molecular functionL-tryptophan transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0015175Molecular functionneutral L-amino acid transmembrane transporter activity
GO_0042605Molecular functionpeptide antigen binding
GO_0015173Molecular functionaromatic amino acid transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0015190Molecular functionL-leucine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC7A5
Protein nameLarge neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
Large neutral amino acids transporter 1
Solute carrier family 7 (Cationic amino acid transporter, y+ system), member 5, isoform CRA_b (Solute carrier family 7 member 5)
SynonymshCG_1789357
CD98LC
LAT1
MPE16
DescriptionFUNCTION: The heterodimer with SLC3A2 functions as a sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, leucine, histidine, methionine, tryptophan, valine, isoleucine and alanine . The heterodimer with SLC3A2 mediates the uptake of L-DOPA (By similarity). Functions as an amino acid exchanger . May play a role in the transport of L-DOPA across the blood-brain barrier (By similarity). May act as the major transporter of tyrosine in fibroblasts (Probable). May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).Can mediate the transport of thyroid hormones diiodothyronine (T2), triiodothyronine (T3) and thyroxine (T4) across the cell membrane . When associated with LAPTM4B, the heterodimer formed by SLC3A2 and SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation . Involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes . Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the membrane . .; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. .

AccessionsENST00000565644.5
Q2MCL6
A0A0C4DGL4
Q01650
ENST00000261622.5