Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3105.89 | 1445 / 1445 | 100% | 73.25 | 183 / 183 |
ovary | 100% | 3599.30 | 180 / 180 | 100% | 114.75 | 430 / 430 |
pancreas | 100% | 2172.77 | 328 / 328 | 100% | 83.96 | 178 / 178 |
skin | 100% | 3619.50 | 1809 / 1809 | 100% | 134.21 | 472 / 472 |
thymus | 100% | 3591.22 | 653 / 653 | 100% | 98.94 | 605 / 605 |
brain | 100% | 2488.00 | 2641 / 2642 | 100% | 116.66 | 705 / 705 |
uterus | 100% | 3844.56 | 170 / 170 | 100% | 129.20 | 458 / 459 |
kidney | 100% | 3313.34 | 89 / 89 | 100% | 80.18 | 898 / 901 |
breast | 100% | 3776.24 | 459 / 459 | 100% | 94.84 | 1114 / 1118 |
intestine | 100% | 3027.30 | 966 / 966 | 100% | 90.32 | 525 / 527 |
prostate | 100% | 3334.79 | 245 / 245 | 100% | 86.77 | 500 / 502 |
adrenal gland | 100% | 3914.78 | 258 / 258 | 100% | 79.79 | 229 / 230 |
lung | 100% | 3384.33 | 577 / 578 | 100% | 95.60 | 1151 / 1155 |
stomach | 100% | 2665.37 | 359 / 359 | 99% | 80.26 | 284 / 286 |
bladder | 100% | 3256.33 | 21 / 21 | 99% | 104.73 | 500 / 504 |
liver | 100% | 1184.74 | 225 / 226 | 99% | 82.50 | 401 / 406 |
adipose | 100% | 3535.71 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 3532.16 | 1335 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 144.49 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 118.88 | 29 / 29 |
spleen | 100% | 3343.86 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 114.10 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 121.63 | 1 / 1 |
muscle | 99% | 2160.48 | 797 / 803 | 0% | 0 | 0 / 0 |
heart | 99% | 2317.26 | 854 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 2512.74 | 920 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031401 | Biological process | positive regulation of protein modification process |
GO_0034244 | Biological process | negative regulation of transcription elongation by RNA polymerase II |
GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0032021 | Cellular component | NELF complex |
GO_0016604 | Cellular component | nuclear body |
GO_0005654 | Cellular component | nucleoplasm |
GO_0000785 | Cellular component | chromatin |
GO_0005886 | Cellular component | plasma membrane |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
GO_0003729 | Molecular function | mRNA binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0003723 | Molecular function | RNA binding |
Gene name | NELFE |
Protein name | Negative elongation factor complex member E Negative elongation factor E (Negative elongation factor complex member E) Negative elongation factor E (NELF-E) (RNA-binding protein RD) Negative elongation factor E |
Synonyms | RDBP RD |
Description | FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex . Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA . .; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. . |
Accessions | ENST00000629797.1 E7ENC7 ENST00000383343.8 [P18615-1] ENST00000440478.5 ENST00000449057.5 ENST00000625905.1 ENST00000375425.9 [P18615-3] E9PD43 ENST00000434518.5 ENST00000456281.5 ENST00000436289.6 ENST00000625436.1 A2ABK4 ENST00000456263.1 ENST00000494956.1 ENST00000441998.5 P18615 ENST00000437732.5 ENST00000420837.1 ENST00000426722.5 ENST00000418423.5 ENST00000448628.6 [P18615-1] ENST00000453084.5 ENST00000420039.1 ENST00000425810.5 ENST00000625993.1 ENST00000457397.6 [P18615-1] ENST00000411745.5 ENST00000429857.6 [P18615-1] ENST00000628497.1 A0A0A0MSN9 E7EWR7 ENST00000418059.1 ENST00000425721.5 A0A0G2JI50 ENST00000424762.5 ENST00000435435.5 ENST00000625545.1 ENST00000383174.8 [P18615-1] A0A0A0MT02 ENST00000375429.8 [P18615-1] ENST00000452147.5 ENST00000458622.1 ENST00000454913.5 ENST00000443464.5 ENST00000444811.6 [P18615-4] ENST00000492539.5 ENST00000424967.5 |