NELFE report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031401Biological processpositive regulation of protein modification process
GO_0034244Biological processnegative regulation of transcription elongation by RNA polymerase II
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032021Cellular componentNELF complex
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003682Molecular functionchromatin binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNELFE
Protein nameNegative elongation factor complex member E
Negative elongation factor E (Negative elongation factor complex member E)
Negative elongation factor E (NELF-E) (RNA-binding protein RD)
Negative elongation factor E
SynonymsRDBP
RD
DescriptionFUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II . The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex . Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA . .; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. .

AccessionsENST00000629797.1
E7ENC7
ENST00000383343.8 [P18615-1]
ENST00000440478.5
ENST00000449057.5
ENST00000625905.1
ENST00000375425.9 [P18615-3]
E9PD43
ENST00000434518.5
ENST00000456281.5
ENST00000436289.6
ENST00000625436.1
A2ABK4
ENST00000456263.1
ENST00000494956.1
ENST00000441998.5
P18615
ENST00000437732.5
ENST00000420837.1
ENST00000426722.5
ENST00000418423.5
ENST00000448628.6 [P18615-1]
ENST00000453084.5
ENST00000420039.1
ENST00000425810.5
ENST00000625993.1
ENST00000457397.6 [P18615-1]
ENST00000411745.5
ENST00000429857.6 [P18615-1]
ENST00000628497.1
A0A0A0MSN9
E7EWR7
ENST00000418059.1
ENST00000425721.5
A0A0G2JI50
ENST00000424762.5
ENST00000435435.5
ENST00000625545.1
ENST00000383174.8 [P18615-1]
A0A0A0MT02
ENST00000375429.8 [P18615-1]
ENST00000452147.5
ENST00000458622.1
ENST00000454913.5
ENST00000443464.5
ENST00000444811.6 [P18615-4]
ENST00000492539.5
ENST00000424967.5