I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 22% ± 8% | |
| glutamatergic neuron | 4 studies | 34% ± 10% | |
| GABAergic neuron | 3 studies | 31% ± 5% | |
| interneuron | 3 studies | 30% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 22% ± 8% | |
| glutamatergic neuron | 4 studies | 34% ± 10% | |
| GABAergic neuron | 3 studies | 31% ± 5% | |
| interneuron | 3 studies | 30% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 28% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 98% | 1858.36 | 1780 / 1809 | 100% | 13.81 | 472 / 472 |
| brain | 98% | 4179.79 | 2593 / 2642 | 100% | 18.35 | 704 / 705 |
| ovary | 100% | 4268.19 | 180 / 180 | 98% | 11.05 | 420 / 430 |
| thymus | 100% | 2355.28 | 652 / 653 | 94% | 4.89 | 569 / 605 |
| adrenal gland | 97% | 1644.31 | 251 / 258 | 97% | 15.72 | 222 / 230 |
| breast | 99% | 2349.37 | 456 / 459 | 90% | 6.93 | 1007 / 1118 |
| lung | 100% | 2619.54 | 577 / 578 | 88% | 4.47 | 1019 / 1155 |
| kidney | 99% | 1785.67 | 88 / 89 | 88% | 6.66 | 794 / 901 |
| esophagus | 95% | 2039.24 | 1379 / 1445 | 86% | 4.14 | 157 / 183 |
| bladder | 100% | 2777.67 | 21 / 21 | 77% | 3.61 | 386 / 504 |
| uterus | 100% | 4343.51 | 170 / 170 | 69% | 4.72 | 316 / 459 |
| prostate | 100% | 2273.34 | 244 / 245 | 68% | 2.47 | 343 / 502 |
| pancreas | 65% | 497.82 | 212 / 328 | 95% | 6.28 | 169 / 178 |
| intestine | 99% | 2238.20 | 956 / 966 | 54% | 2.21 | 285 / 527 |
| stomach | 80% | 1282.64 | 287 / 359 | 67% | 2.79 | 192 / 286 |
| spleen | 100% | 2200.68 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2450.24 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2559.39 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 93% | 9.85 | 74 / 80 |
| heart | 90% | 1025.98 | 779 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 69% | 4.11 | 20 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 2.14 | 27 / 45 |
| peripheral blood | 50% | 380.58 | 467 / 929 | 0% | 0 | 0 / 0 |
| liver | 11% | 71.35 | 24 / 226 | 19% | 0.89 | 77 / 406 |
| muscle | 23% | 164.69 | 187 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0043507 | Biological process | positive regulation of JUN kinase activity |
| GO_0007254 | Biological process | JNK cascade |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0043687 | Biological process | post-translational protein modification |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_2000672 | Biological process | negative regulation of motor neuron apoptotic process |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0030426 | Cellular component | growth cone |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
| GO_0004706 | Molecular function | JUN kinase kinase kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | MAP3K12 |
| Protein name | Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase) Mitogen-activated protein kinase kinase kinase 12 |
| Synonyms | ZPK |
| Description | FUNCTION: Part of a non-canonical MAPK signaling pathway . Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 . May be an activator of the JNK/SAPK pathway. . |
| Accessions | ENST00000547488.6 [Q12852-2] Q12852 F8VUG4 H3BMF0 ENST00000267079.6 [Q12852-1] ENST00000547035.5 [Q12852-2] ENST00000548565.1 ENST00000552365.1 |
