NODAL | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NODAL at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	85%	28.03	2234 / 2642	40%	1.46	279 / 705
breast	98%	39.28	451 / 459	3%	0.06	32 / 1118
uterus	95%	28.14	162 / 170	5%	0.16	23 / 459
intestine	84%	21.00	807 / 966	16%	0.36	84 / 527
muscle	99%	89.30	796 / 803	0%	0	0 / 0
esophagus	79%	14.96	1141 / 1445	20%	0.35	36 / 183
lung	89%	27.38	513 / 578	8%	0.16	87 / 1155
bladder	86%	28.81	18 / 21	10%	0.21	48 / 504
adipose	95%	39.96	1140 / 1204	0%	0	0 / 0
blood vessel	93%	31.16	1247 / 1335	0%	0	0 / 0
ovary	86%	24.21	154 / 180	7%	0.15	30 / 430
prostate	82%	16.33	200 / 245	2%	0.06	12 / 502
skin	75%	35.00	1356 / 1809	1%	0.03	6 / 472
spleen	71%	10.66	170 / 241	0%	0	0 / 0
stomach	49%	8.96	177 / 359	15%	0.51	44 / 286
heart	62%	9.60	538 / 861	0%	0	0 / 0
thymus	56%	7.86	363 / 653	5%	0.17	30 / 605
kidney	37%	4.56	33 / 89	5%	0.09	49 / 901
peripheral blood	42%	6.86	387 / 929	0%	0	0 / 0
pancreas	13%	1.21	43 / 328	3%	0.12	6 / 178
liver	11%	1.17	25 / 226	1%	0.03	6 / 406
adrenal gland	10%	1.03	27 / 258	1%	0.02	2 / 230
tonsil	0%	0	0 / 0	2%	0.04	1 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001893	Biological process	maternal placenta development
GO_0060136	Biological process	embryonic process involved in female pregnancy
GO_0001831	Biological process	trophectodermal cellular morphogenesis
GO_0008283	Biological process	cell population proliferation
GO_0048327	Biological process	axial mesodermal cell fate specification
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0001892	Biological process	embryonic placenta development
GO_0001947	Biological process	heart looping
GO_0090009	Biological process	primitive streak formation
GO_0060137	Biological process	maternal process involved in parturition
GO_0035987	Biological process	endodermal cell differentiation
GO_1901164	Biological process	negative regulation of trophoblast cell migration
GO_0010470	Biological process	regulation of gastrulation
GO_0001889	Biological process	liver development
GO_0060391	Biological process	positive regulation of SMAD protein signal transduction
GO_2000036	Biological process	regulation of stem cell population maintenance
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0032927	Biological process	positive regulation of activin receptor signaling pathway
GO_0060460	Biological process	left lung morphogenesis
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0001890	Biological process	placenta development
GO_0002085	Biological process	inhibition of neuroepithelial cell differentiation
GO_0048382	Biological process	mesendoderm development
GO_0001944	Biological process	vasculature development
GO_0009880	Biological process	embryonic pattern specification
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0033505	Biological process	floor plate morphogenesis
GO_0007281	Biological process	germ cell development
GO_0001842	Biological process	neural fold formation
GO_0042074	Biological process	cell migration involved in gastrulation
GO_0060766	Biological process	negative regulation of androgen receptor signaling pathway
GO_1901383	Biological process	negative regulation of chorionic trophoblast cell proliferation
GO_0010575	Biological process	positive regulation of vascular endothelial growth factor production
GO_0038092	Biological process	nodal signaling pathway
GO_0048701	Biological process	embryonic cranial skeleton morphogenesis
GO_0007420	Biological process	brain development
GO_0060802	Biological process	epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
GO_0010721	Biological process	negative regulation of cell development
GO_0003140	Biological process	determination of left/right asymmetry in lateral mesoderm
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0048546	Biological process	digestive tract morphogenesis
GO_0048859	Biological process	formation of anatomical boundary
GO_0022409	Biological process	positive regulation of cell-cell adhesion
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0035019	Biological process	somatic stem cell population maintenance
GO_0010085	Biological process	polarity specification of proximal/distal axis
GO_0005615	Cellular component	extracellular space
GO_0070698	Molecular function	type I activin receptor binding
GO_0008083	Molecular function	growth factor activity
GO_0016015	Molecular function	morphogen activity
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

Gene name	NODAL
Protein name	Nodal growth differentiation factor Nodal homolog
Synonyms
Description	FUNCTION: Essential for mesoderm formation and axial patterning during embryonic development. .
Accessions	Q96S42 ENST00000414871.1 H7C0E4 ENST00000287139.8

NODAL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review