ARRB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0016567Biological processprotein ubiquitination
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007165Biological processsignal transduction
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0002092Biological processpositive regulation of receptor internalization
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0032717Biological processnegative regulation of interleukin-8 production
GO_0002031Biological processG protein-coupled receptor internalization
GO_0043149Biological processstress fiber assembly
GO_0015031Biological processprotein transport
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005654Cellular componentnucleoplasm
GO_0000139Cellular componentGolgi membrane
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031143Cellular componentpseudopodium
GO_0005905Cellular componentclathrin-coated pit
GO_0000785Cellular componentchromatin
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0004857Molecular functionenzyme inhibitor activity
GO_0005159Molecular functioninsulin-like growth factor receptor binding
GO_1990763Molecular functionarrestin family protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005096Molecular functionGTPase activator activity
GO_0001664Molecular functionG protein-coupled receptor binding
GO_0031701Molecular functionangiotensin receptor binding
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARRB1
Protein nameArrestin beta 1
Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2)
Beta-arrestin-1 (Arrestin beta-1)
SynonymsARR1
DescriptionFUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2). ERK1/2 activated by the beta-arrestin scaffold is largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Recruits c-Src/SRC to ADRB2 resulting in ERK activation. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Inhibits ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Is required for SP-stimulated endocytosis of NK1R and recruits c-Src/SRC to internalized NK1R resulting in ERK1/2 activation, which is required for the antiapoptotic effects of SP. Is involved in proteinase-activated F2RL1-mediated ERK activity. Acts as a signaling scaffold for the AKT1 pathway. Is involved in alpha-thrombin-stimulated AKT1 signaling. Is involved in IGF1-stimulated AKT1 signaling leading to increased protection from apoptosis. Involved in activation of the p38 MAPK signaling pathway and in actin bundle formation. Involved in F2RL1-mediated cytoskeletal rearrangement and chemotaxis. Involved in AGTR1-mediated stress fiber formation by acting together with GNAQ to activate RHOA. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. May serve as nuclear messenger for GPCRs. Involved in OPRD1-stimulated transcriptional regulation by translocating to CDKN1B and FOS promoter regions and recruiting EP300 resulting in acetylation of histone H4. Involved in regulation of LEF1 transcriptional activity via interaction with DVL1 and/or DVL2 Also involved in regulation of receptors other than GPCRs. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Binds phosphoinositides. Binds inositolhexakisphosphate (InsP6) (By similarity). Involved in IL8-mediated granule release in neutrophils. Required for atypical chemokine receptor ACKR2-induced RAC1-LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Involved in the internalization of the atypical chemokine receptor ACKR3. Negatively regulates the NOTCH signaling pathway by mediating the ubiquitination and degradation of NOTCH1 by ITCH. Participates in the recruitment of the ubiquitin-protein ligase to the receptor . .

AccessionsENST00000532525.1
ENST00000524400.5
H0YET9
ENST00000420843.7 [P49407-1]
P49407
ENST00000533609.5
H0YEQ2
E9PM35
H0YD81
H0YDS1
ENST00000532447.5
ENST00000360025.7 [P49407-2]
ENST00000527385.1