PLA2G5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0050766Biological processpositive regulation of phagocytosis
GO_1903028Biological processpositive regulation of opsonization
GO_0019370Biological processleukotriene biosynthetic process
GO_0090265Biological processpositive regulation of immune complex clearance by monocytes and macrophages
GO_0006631Biological processfatty acid metabolic process
GO_0034638Biological processphosphatidylcholine catabolic process
GO_0034374Biological processlow-density lipoprotein particle remodeling
GO_0090385Biological processphagosome-lysosome fusion
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0035965Biological processcardiolipin acyl-chain remodeling
GO_1905036Biological processpositive regulation of antifungal innate immune response
GO_1905164Biological processpositive regulation of phagosome maturation
GO_0006644Biological processphospholipid metabolic process
GO_0010518Biological processpositive regulation of phospholipase activity
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0050482Biological processarachidonic acid secretion
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0032009Cellular componentearly phagosome
GO_0055037Cellular componentrecycling endosome
GO_0005794Cellular componentGolgi apparatus
GO_0032010Cellular componentphagolysosome
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0005543Molecular functionphospholipid binding
GO_0047499Molecular functioncalcium-independent phospholipase A2 activity
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene namePLA2G5
Protein namePhospholipase A2 group V (EC 3.1.1.4) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5)
Synonyms
DescriptionFUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids . Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups . Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (By similarity). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes . Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines . Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane . Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (By similarity). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells . In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way . In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A . Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (By similarity). May regulate antigen processing in antigen-presenting cells (By similarity). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines . .

AccessionsENST00000375108.4
P39877