Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| non-classical monocyte | 22 studies | 34% ± 12% | |
| B cell | 18 studies | 25% ± 7% | |
| memory B cell | 15 studies | 27% ± 9% | |
| monocyte | 11 studies | 23% ± 5% | |
| classical monocyte | 11 studies | 24% ± 7% | |
| conventional dendritic cell | 10 studies | 25% ± 11% | |
| macrophage | 8 studies | 24% ± 8% |
Insufficient scRNA-seq data for expression of SCIMP at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 411.67 | 578 / 578 | 84% | 4.17 | 975 / 1155 |
| breast | 90% | 93.92 | 413 / 459 | 83% | 2.88 | 930 / 1118 |
| intestine | 89% | 264.35 | 856 / 966 | 60% | 2.06 | 317 / 527 |
| kidney | 61% | 74.55 | 54 / 89 | 83% | 3.86 | 747 / 901 |
| prostate | 87% | 99.94 | 214 / 245 | 53% | 1.10 | 264 / 502 |
| stomach | 66% | 63.97 | 237 / 359 | 72% | 3.29 | 206 / 286 |
| bladder | 86% | 99.43 | 18 / 21 | 49% | 1.82 | 248 / 504 |
| ovary | 59% | 48.83 | 106 / 180 | 67% | 1.79 | 287 / 430 |
| pancreas | 43% | 32.28 | 141 / 328 | 78% | 3.51 | 138 / 178 |
| esophagus | 53% | 47.22 | 759 / 1445 | 66% | 2.09 | 121 / 183 |
| uterus | 72% | 52.41 | 123 / 170 | 46% | 1.24 | 212 / 459 |
| liver | 76% | 91.18 | 172 / 226 | 42% | 1.12 | 171 / 406 |
| thymus | 65% | 78.32 | 425 / 653 | 50% | 1.39 | 300 / 605 |
| adrenal gland | 91% | 162.61 | 235 / 258 | 23% | 0.47 | 52 / 230 |
| brain | 30% | 26.92 | 789 / 2642 | 76% | 3.04 | 536 / 705 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 38.01 | 29 / 29 |
| peripheral blood | 100% | 2432.17 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3186.48 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 92% | 157.18 | 1109 / 1204 | 0% | 0 | 0 / 0 |
| skin | 10% | 5.21 | 180 / 1809 | 66% | 3.92 | 312 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 71% | 3.54 | 32 / 45 |
| blood vessel | 70% | 97.52 | 937 / 1335 | 0% | 0 | 0 / 0 |
| heart | 40% | 36.07 | 343 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 25% | 0.62 | 20 / 80 |
| muscle | 2% | 1.26 | 20 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032874 | Biological process | positive regulation of stress-activated MAPK cascade |
| GO_0034154 | Biological process | toll-like receptor 7 signaling pathway |
| GO_0031666 | Biological process | positive regulation of lipopolysaccharide-mediated signaling pathway |
| GO_0002720 | Biological process | positive regulation of cytokine production involved in immune response |
| GO_0034138 | Biological process | toll-like receptor 3 signaling pathway |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_0038123 | Biological process | toll-like receptor TLR1:TLR2 signaling pathway |
| GO_0002732 | Biological process | positive regulation of dendritic cell cytokine production |
| GO_0034142 | Biological process | toll-like receptor 4 signaling pathway |
| GO_0071226 | Biological process | cellular response to molecule of fungal origin |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0001726 | Cellular component | ruffle |
| GO_0001772 | Cellular component | immunological synapse |
| GO_0031256 | Cellular component | leading edge membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0016020 | Cellular component | membrane |
| GO_0030175 | Cellular component | filopodium |
| GO_0045335 | Cellular component | phagocytic vesicle |
| GO_0031259 | Cellular component | uropod membrane |
| GO_0097197 | Cellular component | tetraspanin-enriched microdomain |
| GO_0060090 | Molecular function | molecular adaptor activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SCIMP |
| Protein name | SLP adaptor and CSK interacting membrane protein SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein) |
| Synonyms | UNQ5783/PRO16090 C17orf87 |
| Description | FUNCTION: Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells . It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation . In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (By similarity). . |
| Accessions | ENST00000399600.8 [Q6UWF3-3] ENST00000574297.1 Q6UWF3 ENST00000571800.5 [Q6UWF3-2] ENST00000574081.6 [Q6UWF3-1] I3L1W2 |
