PYCARD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044351Biological processmacropinocytosis
GO_0032722Biological processpositive regulation of chemokine production
GO_0050870Biological processpositive regulation of T cell activation
GO_0051260Biological processprotein homooligomerization
GO_0042104Biological processpositive regulation of activated T cell proliferation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0001773Biological processmyeloid dendritic cell activation
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0090200Biological processpositive regulation of release of cytochrome c from mitochondria
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0044546Biological processNLRP3 inflammasome complex assembly
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0071347Biological processcellular response to interleukin-1
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0010506Biological processregulation of autophagy
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0002588Biological processpositive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO_0050729Biological processpositive regulation of inflammatory response
GO_2000406Biological processpositive regulation of T cell migration
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0002277Biological processmyeloid dendritic cell activation involved in immune response
GO_2001238Biological processpositive regulation of extrinsic apoptotic signaling pathway
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_2001056Biological processpositive regulation of cysteine-type endopeptidase activity
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0002821Biological processpositive regulation of adaptive immune response
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0043065Biological processpositive regulation of apoptotic process
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0050766Biological processpositive regulation of phagocytosis
GO_0046456Biological processicosanoid biosynthetic process
GO_0046330Biological processpositive regulation of JNK cascade
GO_0051607Biological processdefense response to virus
GO_0070269Biological processpyroptotic inflammatory response
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0007231Biological processosmosensory signaling pathway
GO_0002218Biological processactivation of innate immune response
GO_2001242Biological processregulation of intrinsic apoptotic signaling pathway
GO_0006915Biological processapoptotic process
GO_0032729Biological processpositive regulation of type II interferon production
GO_0031647Biological processregulation of protein stability
GO_0035578Cellular componentazurophil granule lumen
GO_0072558Cellular componentNLRP1 inflammasome complex
GO_0072559Cellular componentNLRP3 inflammasome complex
GO_0043025Cellular componentneuronal cell body
GO_0061702Cellular componentcanonical inflammasome complex
GO_0005634Cellular componentnucleus
GO_0005730Cellular componentnucleolus
GO_0005576Cellular componentextracellular region
GO_0005654Cellular componentnucleoplasm
GO_0140738Cellular componentNLRP6 inflammasome complex
GO_0008385Cellular componentIkappaB kinase complex
GO_0005874Cellular componentmicrotubule
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0097169Cellular componentAIM2 inflammasome complex
GO_0034774Cellular componentsecretory granule lumen
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0005829Cellular componentcytosol
GO_0017024Molecular functionmyosin I binding
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0042802Molecular functionidentical protein binding
GO_0070700Molecular functionBMP receptor binding
GO_0019899Molecular functionenzyme binding
GO_0005523Molecular functiontropomyosin binding
GO_0002020Molecular functionprotease binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0032090Molecular functionPyrin domain binding
GO_0005138Molecular functioninterleukin-6 receptor binding

IV. Literature review

[source]
Gene namePYCARD
Protein namePYD and CARD domain containing
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)
SynonymsTMS1
ASC
CARD5
DescriptionFUNCTION: Functions as a key mediator in apoptosis and inflammation . Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner . Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3 . Involved in innate immune response by acting as an integral adapter in the assembly of various inflammasomes (NLRP1, NLRP2, NLRP3, NLRP6, AIM2 and probably IFI16) which recruit and activate caspase-1 leading to processing and secretion of pro-inflammatory cytokines . Caspase-1-dependent inflammation leads to macrophage pyroptosis, a form of cell death . The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions . Clustered PYCARD nucleates the formation of caspase-1 filaments through the interaction of their respective CARD domains, acting as a platform for of caspase-1 polymerization . In the NLRP1 and NLRC4 inflammasomes seems not be required but facilitates the processing of procaspase-1 . In cooperation with NOD2 involved in an inflammasome activated by bacterial muramyl dipeptide leading to caspase-1 activation . May be involved in RIGI-triggered pro-inflammatory responses and inflammasome activation . In collaboration with AIM2 which detects cytosolic double-stranded DNA may also be involved in a caspase-1-independent cell death that involves caspase-8 . In adaptive immunity may be involved in maturation of dendritic cells to stimulate T-cell immunity and in cytoskeletal rearrangements coupled to chemotaxis and antigen uptake may be involved in post-transcriptional regulation of the guanine nucleotide exchange factor DOCK2; the latter function is proposed to involve the nuclear form . Also involved in transcriptional activation of cytokines and chemokines independent of the inflammasome; this function may involve AP-1, NF-kappa-B, MAPK and caspase-8 signaling pathways . For regulation of NF-kappa-B activating and inhibiting functions have been reported . Modulates NF-kappa-B induction at the level of the IKK complex by inhibiting kinase activity of CHUK and IKBK . Proposed to compete with RIPK2 for association with CASP1 thereby down-regulating CASP1-mediated RIPK2-dependent NF-kappa-B activation and activating interleukin-1 beta processing . Modulates host resistance to DNA virus infection, probably by inducing the cleavage of and inactivating CGAS in presence of cytoplasmic double-stranded DNA . .; FUNCTION: [Isoform 2]: May have a regulating effect on the function as inflammasome adapter. .; FUNCTION: [Isoform 3]: Seems to inhibit inflammasome-mediated maturation of interleukin-1 beta. .

AccessionsENST00000561508.1
ENST00000350605.4 [Q9ULZ3-2]
ENST00000247470.10 [Q9ULZ3-1]
Q9ULZ3
H3BP42