ALKAL1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ALKAL1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALKAL1 at tissue level.

III. Associated gene sets

GO_0070378Biological processpositive regulation of ERK5 cascade
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0010976Biological processpositive regulation of neuron projection development
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0030298Molecular functionreceptor signaling protein tyrosine kinase activator activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0030297Molecular functiontransmembrane receptor protein tyrosine kinase activator activity
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameALKAL1
Protein nameALK and LTK ligand 1 (Augmentor beta) (AUG-beta)
SynonymsUNQ9433/PRO34745
FAM150A
DescriptionFUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation . Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation . In contrast to ALKAL2, does not act as a potent physiological ligand for ALK . .

AccessionsQ6UXT8
ENST00000358543.9 [Q6UXT8-1]
ENST00000523939.1 [Q6UXT8-2]