ERBB4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0001755Biological processneural crest cell migration
GO_0007507Biological processheart development
GO_0060045Biological processpositive regulation of cardiac muscle cell proliferation
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0007165Biological processsignal transduction
GO_0007275Biological processmulticellular organism development
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0060749Biological processmammary gland alveolus development
GO_0061026Biological processcardiac muscle tissue regeneration
GO_2000010Biological processpositive regulation of protein localization to cell surface
GO_0033674Biological processpositive regulation of kinase activity
GO_0043653Biological processmitochondrial fragmentation involved in apoptotic process
GO_0038138Biological processERBB4-ERBB4 signaling pathway
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0009880Biological processembryonic pattern specification
GO_0022008Biological processneurogenesis
GO_0045165Biological processcell fate commitment
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030334Biological processregulation of cell migration
GO_0060644Biological processmammary gland epithelial cell differentiation
GO_0021889Biological processolfactory bulb interneuron differentiation
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0072046Biological processestablishment of planar polarity involved in nephron morphogenesis
GO_0007595Biological processlactation
GO_0038135Biological processERBB2-ERBB4 signaling pathway
GO_0007416Biological processsynapse assembly
GO_0007399Biological processnervous system development
GO_0046777Biological processprotein autophosphorylation
GO_0021551Biological processcentral nervous system morphogenesis
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0099645Biological processneurotransmitter receptor localization to postsynaptic specialization membrane
GO_0046427Biological processpositive regulation of receptor signaling pathway via JAK-STAT
GO_0016477Biological processcell migration
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0038130Biological processERBB4 signaling pathway
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0031594Cellular componentneuromuscular junction
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0009925Cellular componentbasal plasma membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0098982Cellular componentGABA-ergic synapse
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0045211Cellular componentpostsynaptic membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005006Molecular functionepidermal growth factor receptor activity
GO_0038131Molecular functionneuregulin receptor activity
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0050811Molecular functionGABA receptor binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERBB4
Protein nameReceptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Erb-b2 receptor tyrosine kinase 4
receptor protein-tyrosine kinase (EC 2.7.10.1)
Alternative protein ERBB4
Uncharacterized protein ERBB4
ERBB4 transcript variant I12DEL
ERBB4 transcript variant I20DEL
SynonymsHER4
DescriptionFUNCTION: Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. Required for mammary gland differentiation, induction of milk proteins and lactation. Acts as cell-surface receptor for the neuregulins NRG1, NRG2, NRG3 and NRG4 and the EGF family members BTC, EREG and HBEGF. Ligand binding triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Ligand specificity and signaling is modulated by alternative splicing, proteolytic processing, and by the formation of heterodimers with other ERBB family members, thereby creating multiple combinations of intracellular phosphotyrosines that trigger ligand- and context-specific cellular responses. Mediates phosphorylation of SHC1 and activation of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Isoform JM-A CYT-1 and isoform JM-B CYT-1 phosphorylate PIK3R1, leading to the activation of phosphatidylinositol 3-kinase and AKT1 and protect cells against apoptosis. Isoform JM-A CYT-1 and isoform JM-B CYT-1 mediate reorganization of the actin cytoskeleton and promote cell migration in response to NRG1. Isoform JM-A CYT-2 and isoform JM-B CYT-2 lack the phosphotyrosine that mediates interaction with PIK3R1, and hence do not phosphorylate PIK3R1, do not protect cells against apoptosis, and do not promote reorganization of the actin cytoskeleton and cell migration. Proteolytic processing of isoform JM-A CYT-1 and isoform JM-A CYT-2 gives rise to the corresponding soluble intracellular domains (4ICD) that translocate to the nucleus, promote nuclear import of STAT5A, activation of STAT5A, mammary epithelium differentiation, cell proliferation and activation of gene expression. The ERBB4 soluble intracellular domains (4ICD) colocalize with STAT5A at the CSN2 promoter to regulate transcription of milk proteins during lactation. The ERBB4 soluble intracellular domains can also translocate to mitochondria and promote apoptosis. .

AccessionsA0A0P0IT07
ENST00000260943.11
Q53QS8
L8E872
Q4ZG14
Q53T57
A0A0P0I3A3
E9PDR1
ENST00000342788.9 [Q15303-1]
H3BLT0
ENST00000260943.11 [Q15303-4]
Q15303
ENST00000436443.5 [Q15303-3]
ENST00000435846.1
Q53R48
Q580Q7
Q53R25