DSTYK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033674Biological processpositive regulation of kinase activity
GO_0045743Biological processpositive regulation of fibroblast growth factor receptor signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0070161Cellular componentanchoring junction
GO_0005737Cellular componentcytoplasm
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0004712Molecular functionprotein serine/threonine/tyrosine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameDSTYK
Protein nameDual serine/threonine and tyrosine protein kinase
Dual serine/threonine and tyrosine protein kinase (EC 2.7.12.1) (Dusty protein kinase) (Dusty PK) (RIP-homologous kinase) (Receptor-interacting serine/threonine-protein kinase 5) (Sugen kinase 496) (SgK496)
Dual serine/threonine and tyrosine protein kinase isoform X7
SynonymsHDCMD38P
KIAA0472
SGK496
RIP5
RIPK5
DescriptionFUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation . Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death . In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types . .

AccessionsA0AA96PM41
ENST00000367161.7 [Q6XUX3-2]
A0AA96T3V7
ENST00000367162.8 [Q6XUX3-1]
Q6XUX3