PHB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042177Biological processnegative regulation of protein catabolic process
GO_0023035Biological processCD40 signaling pathway
GO_0008285Biological processnegative regulation of cell population proliferation
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0045917Biological processpositive regulation of complement activation
GO_0001649Biological processosteoblast differentiation
GO_0007165Biological processsignal transduction
GO_0048661Biological processpositive regulation of smooth muscle cell proliferation
GO_0010628Biological processpositive regulation of gene expression
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0050847Biological processprogesterone receptor signaling pathway
GO_2000323Biological processnegative regulation of glucocorticoid receptor signaling pathway
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0044830Biological processmodulation by host of viral RNA genome replication
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0045745Biological processpositive regulation of G protein-coupled receptor signaling pathway
GO_0046718Biological processsymbiont entry into host cell
GO_0071897Biological processDNA biosynthetic process
GO_0007005Biological processmitochondrion organization
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0050821Biological processprotein stabilization
GO_0042113Biological processB cell activation
GO_0039529Biological processRIG-I signaling pathway
GO_0006355Biological processregulation of DNA-templated transcription
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0040029Biological processepigenetic regulation of gene expression
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_1990051Biological processactivation of protein kinase C activity
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0072538Biological processT-helper 17 type immune response
GO_0071354Biological processcellular response to interleukin-6
GO_0140374Biological processantiviral innate immune response
GO_0030308Biological processnegative regulation of cell growth
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_0009986Cellular componentcell surface
GO_0035632Cellular componentmitochondrial prohibitin complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0001850Molecular functioncomplement component C3a binding
GO_0031871Molecular functionproteinase activated receptor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042826Molecular functionhistone deacetylase binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0001851Molecular functioncomplement component C3b binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePHB1
Protein nameProhibitin 1
Prohibitin
SynonymsPHB
hCG_29613
DescriptionFUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus . Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). .; FUNCTION: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Regulates mitochondrial respiration activity playing a role in cellular aging . The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation . Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 . .; FUNCTION: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses . Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells . .; FUNCTION: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (By similarity). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). .

AccessionsC9JW96
ENST00000446735.6
E7ESE2
ENST00000512041.7 [P35232-1]
ENST00000696365.1 [P35232-2]
ENST00000504124.6 [P35232-1]
ENST00000512041
ENST00000419140.7 [P35232-1]
ENST00000511832.6 [P35232-1]
ENST00000504124
E9PCW0
P35232
ENST00000614445.5 [P35232-1]
C9JZ20
ENST00000300408.8 [P35232-1]
Q6FHP5
ENST00000419140
ENST00000617874.5 [P35232-1]
A8K401