Biological process

DDX58 signaling pathway, RIG-I signalling pathway, RIG-I-like receptor (RLR) signaling pathway, RIG-like helicase signaling pathway, RIG-like receptor signaling pathway, RLH signaling pathway, RLR signaling pathway, retinoic acid inducible gene I signaling pathway

The series of molecular signals initiated by the binding ssRNA or dsRNA from another organism to the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I detects RNA synthesized during viral replication or shed by non-viral pathogens, and triggers a signaling pathway to protect the host against infection, for example by inducing the expression of cytokines.