LSM14A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	39 studies	30% ± 15%	Explore
B cell	35 studies	29% ± 9%	Explore
natural killer cell	35 studies	28% ± 8%	Explore
fibroblast	29 studies	27% ± 11%	Explore
CD8-positive, alpha-beta T cell	29 studies	26% ± 8%	Explore
T cell	28 studies	27% ± 7%	Explore
CD4-positive, alpha-beta T cell	28 studies	27% ± 7%	Explore
pericyte	26 studies	26% ± 8%	Explore
smooth muscle cell	24 studies	24% ± 5%	Explore
regulatory T cell	22 studies	28% ± 7%	Explore
memory B cell	20 studies	29% ± 6%	Explore
naive B cell	19 studies	27% ± 6%	Explore
macrophage	18 studies	25% ± 10%	Explore
mature NK T cell	17 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	27% ± 7%	Explore
gamma-delta T cell	16 studies	31% ± 12%	Explore
endothelial cell of lymphatic vessel	15 studies	26% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	32% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	28% ± 7%	Explore
conventional dendritic cell	14 studies	24% ± 14%	Explore
basal cell	13 studies	28% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	29% ± 8%	Explore
connective tissue cell	13 studies	26% ± 8%	Explore
mucosal invariant T cell	13 studies	29% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	32% ± 9%	Explore
classical monocyte	12 studies	23% ± 9%	Explore
non-classical monocyte	12 studies	26% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	28% ± 7%	Explore
capillary endothelial cell	12 studies	21% ± 6%	Explore
astrocyte	12 studies	32% ± 14%	Explore
epithelial cell	12 studies	39% ± 20%	Explore
monocyte	12 studies	26% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	28% ± 10%	Explore
myofibroblast cell	11 studies	28% ± 7%	Explore
vein endothelial cell	11 studies	24% ± 10%	Explore
endothelial cell of artery	10 studies	21% ± 3%	Explore
dendritic cell	10 studies	30% ± 17%	Explore
plasmacytoid dendritic cell	10 studies	26% ± 10%	Explore
endothelial cell of vascular tree	10 studies	23% ± 12%	Explore
ciliated cell	10 studies	30% ± 12%	Explore
adipocyte	9 studies	37% ± 10%	Explore
mast cell	9 studies	23% ± 7%	Explore
abnormal cell	8 studies	27% ± 11%	Explore
oligodendrocyte	8 studies	33% ± 12%	Explore
mesothelial cell	8 studies	32% ± 11%	Explore
microglial cell	8 studies	32% ± 11%	Explore
type I pneumocyte	8 studies	27% ± 8%	Explore
plasma cell	7 studies	25% ± 9%	Explore
oligodendrocyte precursor cell	7 studies	32% ± 15%	Explore
myeloid cell	7 studies	28% ± 6%	Explore
type II pneumocyte	7 studies	25% ± 7%	Explore
retinal cone cell	7 studies	38% ± 12%	Explore
retinal rod cell	7 studies	42% ± 10%	Explore
T follicular helper cell	7 studies	27% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	27% ± 3%	Explore
leukocyte	6 studies	30% ± 7%	Explore
GABAergic neuron	6 studies	31% ± 15%	Explore
neuron	6 studies	35% ± 16%	Explore
glutamatergic neuron	6 studies	34% ± 17%	Explore
lymphocyte	6 studies	34% ± 12%	Explore
precursor B cell	6 studies	33% ± 9%	Explore
innate lymphoid cell	6 studies	27% ± 8%	Explore
amacrine cell	6 studies	36% ± 9%	Explore
retina horizontal cell	6 studies	30% ± 8%	Explore
Mueller cell	6 studies	31% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	27% ± 8%	Explore
hematopoietic precursor cell	5 studies	35% ± 9%	Explore
plasmablast	5 studies	41% ± 18%	Explore
progenitor cell	5 studies	25% ± 5%	Explore
retinal bipolar neuron	5 studies	43% ± 13%	Explore
interneuron	5 studies	46% ± 22%	Explore
hematopoietic stem cell	5 studies	27% ± 7%	Explore
pro-B cell	5 studies	35% ± 4%	Explore
club cell	5 studies	26% ± 9%	Explore
cardiac muscle cell	5 studies	29% ± 3%	Explore
goblet cell	5 studies	36% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	26% ± 2%	Explore
squamous epithelial cell	4 studies	29% ± 20%	Explore
pancreatic A cell	4 studies	30% ± 12%	Explore
exhausted T cell	4 studies	32% ± 4%	Explore
glial cell	4 studies	29% ± 13%	Explore
granule cell	4 studies	28% ± 7%	Explore
ON-bipolar cell	4 studies	31% ± 11%	Explore
immature B cell	4 studies	30% ± 6%	Explore
retinal pigment epithelial cell	4 studies	41% ± 18%	Explore
mononuclear phagocyte	4 studies	28% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	19% ± 3%	Explore
hepatocyte	4 studies	44% ± 18%	Explore
enteroendocrine cell	4 studies	28% ± 12%	Explore
T-helper 17 cell	4 studies	24% ± 3%	Explore
kidney loop of Henle epithelial cell	3 studies	17% ± 2%	Explore
podocyte	3 studies	26% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	25% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	19% ± 2%	Explore
neural crest cell	3 studies	26% ± 7%	Explore
retinal ganglion cell	3 studies	26% ± 1%	Explore
extravillous trophoblast	3 studies	30% ± 8%	Explore
placental villous trophoblast	3 studies	33% ± 12%	Explore
erythroblast	3 studies	44% ± 19%	Explore
GABAergic amacrine cell	3 studies	28% ± 6%	Explore
OFF-bipolar cell	3 studies	27% ± 7%	Explore
glycinergic amacrine cell	3 studies	32% ± 6%	Explore
rod bipolar cell	3 studies	57% ± 11%	Explore
germinal center B cell	3 studies	39% ± 5%	Explore
muscle cell	3 studies	42% ± 23%	Explore
pancreatic ductal cell	3 studies	42% ± 17%	Explore
granulocyte	3 studies	26% ± 5%	Explore
alveolar macrophage	3 studies	32% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 10%	Explore
transit amplifying cell	3 studies	39% ± 26%	Explore
T-helper 1 cell	3 studies	29% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	26% ± 8%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	22% ± 5%	Explore
double negative thymocyte	3 studies	43% ± 12%	Explore
myoepithelial cell	3 studies	27% ± 7%	Explore
platelet	3 studies	18% ± 1%	Explore
erythrocyte	3 studies	33% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	28% ± 7%	Explore
lung	13 studies	26% ± 8%	Explore
brain	12 studies	31% ± 15%	Explore
eye	8 studies	42% ± 13%	Explore
intestine	7 studies	24% ± 10%	Explore
kidney	6 studies	23% ± 5%	Explore
heart	5 studies	25% ± 3%	Explore
placenta	4 studies	25% ± 6%	Explore
bone marrow	4 studies	29% ± 7%	Explore
lymph node	4 studies	24% ± 5%	Explore
liver	4 studies	41% ± 19%	Explore
adipose	4 studies	29% ± 4%	Explore
pancreas	3 studies	35% ± 14%	Explore
uterus	3 studies	25% ± 12%	Explore
breast	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6743.94	1445 / 1445	100%	86.59	183 / 183
intestine	100%	7057.73	966 / 966	100%	82.94	527 / 527
lung	100%	6328.34	578 / 578	100%	98.08	1155 / 1155
ovary	100%	8275.27	180 / 180	100%	92.62	430 / 430
prostate	100%	6507.22	245 / 245	100%	97.07	502 / 502
uterus	100%	8094.85	170 / 170	100%	111.70	459 / 459
brain	100%	4533.99	2640 / 2642	100%	85.57	705 / 705
breast	100%	7117.67	459 / 459	100%	126.45	1117 / 1118
thymus	100%	7636.47	653 / 653	100%	134.33	604 / 605
stomach	100%	4396.19	359 / 359	100%	80.39	285 / 286
bladder	100%	7219.52	21 / 21	100%	94.12	502 / 504
kidney	100%	5176.84	89 / 89	99%	91.59	896 / 901
skin	100%	7072.87	1809 / 1809	99%	90.28	467 / 472
pancreas	99%	3102.82	326 / 328	99%	81.66	177 / 178
liver	100%	3203.93	226 / 226	99%	54.41	401 / 406
adrenal gland	100%	5929.82	258 / 258	98%	62.54	226 / 230
adipose	100%	6689.15	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7382.46	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	98.71	29 / 29
muscle	100%	6286.20	803 / 803	0%	0	0 / 0
spleen	100%	6225.39	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	86.97	45 / 45
ureter	0%	0	0 / 0	100%	53.35	1 / 1
heart	99%	3826.03	852 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	57.59	78 / 80
peripheral blood	97%	4536.30	898 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034063	Biological process	stress granule assembly
GO_0060340	Biological process	positive regulation of type I interferon-mediated signaling pathway
GO_0051607	Biological process	defense response to virus
GO_0033962	Biological process	P-body assembly
GO_0090307	Biological process	mitotic spindle assembly
GO_0039529	Biological process	RIG-I signaling pathway
GO_0017148	Biological process	negative regulation of translation
GO_0072686	Cellular component	mitotic spindle
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0000932	Cellular component	P-body
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0010494	Cellular component	cytoplasmic stress granule
GO_0003727	Molecular function	single-stranded RNA binding
GO_0003690	Molecular function	double-stranded DNA binding
GO_0003729	Molecular function	mRNA binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003725	Molecular function	double-stranded RNA binding

IV. Literature review

[source]

Gene name	LSM14A
Protein name	LSM14A mRNA processing body assembly factor (Protein LSM14 homolog A) Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A) LSM14A mRNA processing body assembly factor Protein LSM14 homolog A
Synonyms	C19orf13 RAP55 FAM61A RAP55A
Description	FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation . Acts as a repressor of mRNA translation . May play a role in mitotic spindle assembly . .
Accessions	ENST00000575811.5 [Q8ND56-2] Q8ND56 ENST00000575110.5 I3L4Q1 ENST00000585887.3 ENST00000544216.8 [Q8ND56-2] ENST00000589878.5 A0A096LP11 ENST00000433627.9 [Q8ND56-1] ENST00000570462.5 [Q8ND56-1] A0A0G2JQ95 A0A140TA76 ENST00000624888.1 K7EMZ9 A0A140TA66 ENST00000575388.1 ENST00000575697.1 ENST00000586157.2 ENST00000540746.6 [Q8ND56-3]

LSM14A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review