OAS3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OAS3 at tissue level.

III. Associated gene sets

GO_0006139Biological processnucleobase-containing compound metabolic process
GO_0045071Biological processnegative regulation of viral genome replication
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0071650Biological processnegative regulation of chemokine (C-C motif) ligand 5 production
GO_0045087Biological processinnate immune response
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0035395Biological processnegative regulation of chemokine (C-X-C motif) ligand 9 production
GO_0071659Biological processnegative regulation of IP-10 production
GO_0060700Biological processregulation of ribonuclease activity
GO_0039529Biological processRIG-I signaling pathway
GO_0042742Biological processdefense response to bacterium
GO_0071639Biological processpositive regulation of monocyte chemotactic protein-1 production
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0039530Biological processMDA-5 signaling pathway
GO_2000342Biological processnegative regulation of chemokine (C-X-C motif) ligand 2 production
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0001730Molecular function2'-5'-oligoadenylate synthetase activity
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameOAS3
Protein name2'-5'-oligoadenylate synthetase 3
Alternative protein OAS3
2'-5' oligoadenylate synthase (EC 2.7.7.84)
2'-5'-oligoadenylate synthase 3 ((2-5')oligo(A) synthase 3) (2-5A synthase 3) (EC 2.7.7.84) (p100 OAS) (p100OAS)
SynonymsP/OKcl.4
DescriptionFUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). .

AccessionsA0A7P0T8J8
A0A7P0TA50
A0A7P0T7V2
A0A7P0TAV3
ENST00000680230.1
ENST00000681007.1
F8VWK9
A0A7P0TAC8
ENST00000679912.1
ENST00000681594.1
A0A7P0T9Z5
A0A7P0Z4Q3
A0A7P0T9W6
F8VS35
A0A7P0Z4F1
A0A7P0TB72
A0A7P0TA44
Q9Y6K5
ENST00000679562.1
ENST00000679354.1
ENST00000679812.1
ENST00000681002.1
A0A7P0T884
A0A7P0TAC0
ENST00000680966.1
ENST00000679493.1
ENST00000679483.1
ENST00000681134.1
ENST00000680044.1
A0A7P0TAU8
L0R6L5
ENST00000681764.1
A0A7P0T9J0
ENST00000680177.1
ENST00000680438.1
A0A7P0Z4D0
A0A7P0T8S7
ENST00000228928.12
ENST00000681147.1
A0A7P0Z4F5
A0A7P0TB73
ENST00000681572.1
ENST00000680161.1
ENST00000551007.1
ENST00000681085.1
ENST00000679547.1
ENST00000679505.1
ENST00000681497.1
ENST00000680090.1
ENST00000548514.2
ENST00000679517.1
ENST00000681346.1
A0A7P0TAT5
ENST00000680293.1
A0A7P0TAS0