PHB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_1900208Biological processregulation of cardiolipin metabolic process
GO_0023035Biological processCD40 signaling pathway
GO_0060762Biological processregulation of branching involved in mammary gland duct morphogenesis
GO_0007062Biological processsister chromatid cohesion
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0002639Biological processpositive regulation of immunoglobulin production
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0030449Biological processregulation of complement activation
GO_1904959Biological processregulation of cytochrome-c oxidase activity
GO_0060744Biological processmammary gland branching involved in thelarche
GO_0033598Biological processmammary gland epithelial cell proliferation
GO_0060749Biological processmammary gland alveolus development
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0031536Biological processpositive regulation of exit from mitosis
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0033147Biological processnegative regulation of intracellular estrogen receptor signaling pathway
GO_0033600Biological processnegative regulation of mammary gland epithelial cell proliferation
GO_0007005Biological processmitochondrion organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0042113Biological processB cell activation
GO_0006606Biological processprotein import into nucleus
GO_0039529Biological processRIG-I signaling pathway
GO_0000423Biological processmitophagy
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0030520Biological processestrogen receptor signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016477Biological processcell migration
GO_1990051Biological processactivation of protein kinase C activity
GO_0071456Biological processcellular response to hypoxia
GO_0140374Biological processantiviral innate immune response
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005743Cellular componentmitochondrial inner membrane
GO_0016363Cellular componentnuclear matrix
GO_0098982Cellular componentGABA-ergic synapse
GO_0009986Cellular componentcell surface
GO_0048786Cellular componentpresynaptic active zone
GO_0071944Cellular componentcell periphery
GO_0035632Cellular componentmitochondrial prohibitin complex
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0030424Cellular componentaxon
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0046625Molecular functionsphingolipid binding
GO_0042802Molecular functionidentical protein binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0033218Molecular functionamide binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePHB2
Protein nameProhibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)
Prohibitin 2 (Prohibitin-2 variant)
Prohibitin
SynonymsBAP
REA
DescriptionFUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .; FUNCTION: In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (By similarity). Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration . Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity . Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation . Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 . .; FUNCTION: In the nucleus, serves as transcriptional co-regulator (Probable). Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity (By similarity). .; FUNCTION: In the plasma membrane, is involved in IGFBP6-induced cell migration . Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). .; FUNCTION: (Microbial infection) Involved in human enterovirus 71/EV-71 infection by enhancing the autophagy mechanism during the infection. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. .

AccessionsENST00000399433.7
ENST00000542912.5
F5H0C5
Q99623
F5H2D2
A0A7I2V5F0
ENST00000545167.5
ENST00000544888.5
ENST00000536316.3
A0A976LZI3
F5H3X6
J3KPX7
ENST00000440277.6 [Q99623-2]
ENST00000546111.5
A0A3G2KQ93
ENST00000535923.6 [Q99623-1]
U3KPZ5
F5GWA7
ENST00000545555.2
ENST00000678829.1
ENST00000676496.1
F5GY37