I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| microglial cell | 3 studies | 22% ± 2% | |
| GABAergic neuron | 3 studies | 27% ± 5% | |
| glutamatergic neuron | 3 studies | 31% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| microglial cell | 3 studies | 22% ± 2% | |
| GABAergic neuron | 3 studies | 27% ± 5% | |
| glutamatergic neuron | 3 studies | 31% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 466.87 | 1444 / 1445 | 100% | 12.37 | 183 / 183 |
| breast | 100% | 564.98 | 459 / 459 | 100% | 8.09 | 1116 / 1118 |
| bladder | 100% | 528.10 | 21 / 21 | 100% | 8.23 | 503 / 504 |
| ovary | 100% | 340.85 | 180 / 180 | 100% | 7.97 | 429 / 430 |
| thymus | 100% | 611.07 | 653 / 653 | 100% | 5.24 | 602 / 605 |
| lung | 100% | 627.48 | 576 / 578 | 100% | 7.44 | 1153 / 1155 |
| prostate | 100% | 376.59 | 245 / 245 | 99% | 6.22 | 499 / 502 |
| stomach | 100% | 469.63 | 359 / 359 | 99% | 8.83 | 284 / 286 |
| uterus | 100% | 505.15 | 170 / 170 | 99% | 6.73 | 455 / 459 |
| skin | 100% | 648.18 | 1804 / 1809 | 99% | 10.01 | 469 / 472 |
| intestine | 100% | 406.66 | 965 / 966 | 99% | 7.48 | 522 / 527 |
| brain | 99% | 540.10 | 2613 / 2642 | 100% | 13.19 | 705 / 705 |
| kidney | 100% | 594.04 | 89 / 89 | 99% | 6.33 | 891 / 901 |
| liver | 100% | 909.50 | 225 / 226 | 99% | 5.54 | 402 / 406 |
| adrenal gland | 100% | 1124.65 | 258 / 258 | 98% | 12.78 | 226 / 230 |
| pancreas | 100% | 572.18 | 328 / 328 | 98% | 4.74 | 174 / 178 |
| adipose | 100% | 587.87 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 7.42 | 29 / 29 |
| spleen | 100% | 570.19 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 5.74 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.63 | 1 / 1 |
| muscle | 100% | 697.66 | 802 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 461.13 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 770.08 | 925 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 7.70 | 79 / 80 |
| heart | 95% | 471.50 | 817 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030851 | Biological process | granulocyte differentiation |
| GO_0140374 | Biological process | antiviral innate immune response |
| GO_0034605 | Biological process | cellular response to heat |
| GO_0039529 | Biological process | RIG-I signaling pathway |
| GO_0005758 | Cellular component | mitochondrial intermembrane space |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0140545 | Molecular function | ATP-dependent protein disaggregase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003674 | Molecular function | molecular_function |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | CLPB |
| Protein name | Mitochondrial disaggregase (EC 3.6.1.-) (Suppressor of potassium transport defect 3) [Cleaved into: Mitochondrial disaggregase, cleaved form] CLPB protein ClpB caseinolytic peptidase B homolog (E. coli), isoform CRA_a (Testicular secretory protein Li 11) Caseinolytic mitochondrial matrix peptidase chaperone subunit B |
| Synonyms | SKD3 hCG_24098 |
| Description | FUNCTION: Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins . Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 . Plays a role in granulocyte differentiation . . |
| Accessions | A0A140VK11 ENST00000539148.3 ENST00000535990.6 F5GX99 A0A2R8YDH5 ENST00000535477.6 ENST00000340729.9 [Q9H078-3] Q7Z777 F5H7A5 A0A2R8Y7E8 F6SS08 ENST00000538021.5 ENST00000536297.1 H0YGM0 ENST00000538039.6 [Q9H078-2] F5H392 ENST00000294053.9 [Q9H078-1] Q9H078 A0A2U3TZY2 ENST00000544683.5 H0YG50 A0A2R8Y602 A0A2R8Y6R5 ENST00000646117.1 ENST00000543042.6 ENST00000642187.1 ENST00000542555.3 ENST00000642288.1 |
