RIGI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0034344Biological processregulation of type III interferon production
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0002735Biological processpositive regulation of myeloid dendritic cell cytokine production
GO_0043330Biological processresponse to exogenous dsRNA
GO_0009615Biological processresponse to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0051607Biological processdefense response to virus
GO_0060760Biological processpositive regulation of response to cytokine stimulus
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0009597Biological processdetection of virus
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_0030334Biological processregulation of cell migration
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0039529Biological processRIG-I signaling pathway
GO_0010467Biological processgene expression
GO_0071360Biological processcellular response to exogenous dsRNA
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0140374Biological processantiviral innate immune response
GO_0032587Cellular componentruffle membrane
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_1990904Cellular componentribonucleoprotein complex
GO_0038187Molecular functionpattern recognition receptor activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0003724Molecular functionRNA helicase activity
GO_0003690Molecular functiondouble-stranded DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005525Molecular functionGTP binding
GO_0008270Molecular functionzinc ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameRIGI
Protein nameAntiviral innate immune response receptor RIG-I (ATP-dependent RNA helicase DDX58) (EC 3.6.4.13) (DEAD box protein 58) (RIG-I-like receptor 1) (RLR-1) (RNA sensor RIG-I) (Retinoic acid-inducible gene 1 protein) (RIG-1) (Retinoic acid-inducible gene I protein) (RIG-I)
DDX58 protein
RNA helicase (EC 3.6.4.13)
RNA sensor RIG-I
Alternative protein DDX58
SynonymsDDX58
DescriptionFUNCTION: Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and pro-inflammatory cytokines . Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments . The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms . Upon activation, associates with mitochondria antiviral signaling protein (MAVS/IPS1) that activates the IKK-related kinases TBK1 and IKBKE which in turn phosphorylate the interferon regulatory factors IRF3 and IRF7, activating transcription of antiviral immunological genes including the IFN-alpha and IFN-beta interferons . Ligands include 5'-triphosphorylated ssRNAs and dsRNAs but also short dsRNAs (<1 kb in length) . In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential . Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity . A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity . Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV) . It also detects rotaviruses and reoviruses . Detects and binds to SARS-CoV-2 RNAs which is inhibited by m6A RNA modifications (Ref.69). Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV) . Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration. .

AccessionsA0A7P0Z442
A0A7P0T9I8
A2A376
ENST00000379868.6 [O95786-2]
ENST00000379883.3 [O95786-1]
O95786
B3KWW1
ENST00000679665.1
ENST00000680733.1
A0A7P0Z425
ENST00000379868
Q3B797
ENST00000679859.1
L8E813
ENST00000679771.1