RNF135 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of RNF135 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0016567Biological processprotein ubiquitination
GO_0032728Biological processpositive regulation of interferon-beta production
GO_0000209Biological processprotein polyubiquitination
GO_0045087Biological processinnate immune response
GO_0010994Biological processfree ubiquitin chain polymerization
GO_0045088Biological processregulation of innate immune response
GO_0039529Biological processRIG-I signaling pathway
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0140374Biological processantiviral innate immune response
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0010494Cellular componentcytoplasmic stress granule
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0039552Molecular functionRIG-I binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRNF135
Protein nameRing finger protein 135
E3 ubiquitin-protein ligase RNF135 (EC 2.3.2.27) (RIG-I E3 ubiquitin ligase) (REUL) (RING finger protein 135) (RING finger protein leading to RIG-I activation) (Riplet) (RING-type E3 ubiquitin transferase RNF135)
SynonymsL13
DescriptionFUNCTION: E2-dependent E3 ubiquitin-protein ligase that functions as a RIGI coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response . Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIGI oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway . Through a ubiquitin-independent parallel mechanism, which consists in bridging RIGI filaments forming on longer viral RNAs, further activates the RIG-I signaling pathway . This second mechanism that synergizes with the ubiquitin-dependent one would thereby allow an RNA length-dependent regulation of the RIG-I signaling pathway (Probable). Associated with the E2 ligase UBE2N, also constitutively synthesizes unanchored 'Lys-63'-linked polyubiquitin chains that may also activate the RIG-I signaling pathway . .

AccessionsENST00000443677.6
ENST00000324689.8 [Q8IUD6-2]
ENST00000708425.1 [Q8IUD6-2]
ENST00000708427.1 [Q8IUD6-3]
ENST00000708426.1 [Q8IUD6-1]
H7C3H8
ENST00000434242.2
Q8IUD6
ENST00000580444.2
J3QS68
ENST00000535306.6 [Q8IUD6-3]
K7EQF1
ENST00000328381.10 [Q8IUD6-1]