TRIM25 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM25 at tissue level.

III. Associated gene sets

GO_0033280Biological processresponse to vitamin D
GO_0043627Biological processresponse to estrogen
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0032880Biological processregulation of protein localization
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0046597Biological processnegative regulation of viral entry into host cell
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0039529Biological processRIG-I signaling pathway
GO_0019076Biological processviral release from host cell
GO_0044790Biological processsuppression of viral release by host
GO_0006513Biological processprotein monoubiquitination
GO_0006979Biological processresponse to oxidative stress
GO_0046596Biological processregulation of viral entry into host cell
GO_0002753Biological processcytoplasmic pattern recognition receptor signaling pathway
GO_0036503Biological processERAD pathway
GO_0140374Biological processantiviral innate immune response
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0016874Molecular functionligase activity
GO_0045296Molecular functioncadherin binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0039552Molecular functionRIG-I binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM25
Protein nameE3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Tripartite motif containing 25
Alternative protein TRIM25
SynonymsEFP
ZNF147
RNF147
DescriptionFUNCTION: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase . Involved in innate immune defense against viruses by mediating ubiquitination of RIGI and IFIH1 . Mediates 'Lys-63'-linked polyubiquitination of the RIGI N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection . Mediates 'Lys-63'-linked polyubiquitination of IFIH1 . Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway . Mediates estrogen action in various target organs . Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 . Plays a role in promoting the restart of stalled replication forks via interaction with the KHDC3L-OOEP scaffold and subsequent ubiquitination of BLM, resulting in the recruitment and retainment of BLM at DNA replication forks (By similarity). Plays an essential role in the antiviral activity of ZAP/ZC3HAV1; an antiviral protein which inhibits the replication of certain viruses. Mechanistically, mediates 'Lys-63'-linked polyubiquitination of ZAP/ZC3HAV1 that is required for its optimal binding to target mRNA . Mediates also the ubiquitination of various substrates implicated in stress granule formation, nonsense-mediated mRNA decay, nucleoside synthesis and mRNA translation and stability . .

AccessionsENST00000648772.1
L0R8K6
ENST00000572021.6
Q14258
I3L2W4
ENST00000682766.1
A0A3B3IUA7
ENST00000537230.3
ENST00000316881.9