I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 5 studies | 32% ± 14% | |
| type B pancreatic cell | 4 studies | 49% ± 22% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 5 studies | 32% ± 14% | |
| type B pancreatic cell | 4 studies | 49% ± 22% |
Insufficient scRNA-seq data for expression of ADCYAP1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 94% | 236.41 | 308 / 328 | 75% | 8.98 | 134 / 178 |
| brain | 78% | 590.35 | 2055 / 2642 | 41% | 1.79 | 291 / 705 |
| intestine | 78% | 229.35 | 749 / 966 | 23% | 1.05 | 120 / 527 |
| breast | 63% | 192.58 | 290 / 459 | 28% | 2.16 | 314 / 1118 |
| stomach | 64% | 173.67 | 230 / 359 | 24% | 0.85 | 68 / 286 |
| esophagus | 66% | 236.08 | 956 / 1445 | 20% | 0.46 | 37 / 183 |
| kidney | 49% | 61.60 | 44 / 89 | 27% | 3.19 | 239 / 901 |
| lung | 51% | 201.40 | 292 / 578 | 24% | 1.04 | 273 / 1155 |
| bladder | 52% | 215.43 | 11 / 21 | 20% | 0.62 | 102 / 504 |
| prostate | 56% | 207.63 | 136 / 245 | 14% | 0.33 | 71 / 502 |
| uterus | 57% | 165.09 | 97 / 170 | 12% | 0.71 | 57 / 459 |
| adipose | 68% | 265.70 | 815 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 12% | 20.16 | 31 / 258 | 46% | 65.53 | 105 / 230 |
| blood vessel | 52% | 153.83 | 696 / 1335 | 0% | 0 | 0 / 0 |
| skin | 24% | 64.46 | 426 / 1809 | 6% | 0.18 | 28 / 472 |
| heart | 25% | 32.97 | 211 / 861 | 0% | 0 | 0 / 0 |
| thymus | 19% | 31.86 | 122 / 653 | 5% | 0.10 | 28 / 605 |
| ovary | 11% | 13.30 | 19 / 180 | 8% | 1.58 | 34 / 430 |
| liver | 10% | 10.30 | 22 / 226 | 4% | 0.15 | 16 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.35 | 6 / 45 |
| muscle | 8% | 11.42 | 62 / 803 | 0% | 0 | 0 / 0 |
| spleen | 7% | 9.62 | 18 / 241 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| peripheral blood | 1% | 1.99 | 13 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0060124 | Biological process | positive regulation of growth hormone secretion |
| GO_0007218 | Biological process | neuropeptide signaling pathway |
| GO_0045786 | Biological process | negative regulation of cell cycle |
| GO_0043547 | Biological process | positive regulation of GTPase activity |
| GO_0031175 | Biological process | neuron projection development |
| GO_0032880 | Biological process | regulation of protein localization |
| GO_0019933 | Biological process | cAMP-mediated signaling |
| GO_0007565 | Biological process | female pregnancy |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0045860 | Biological process | positive regulation of protein kinase activity |
| GO_0007190 | Biological process | activation of adenylate cyclase activity |
| GO_0008277 | Biological process | regulation of G protein-coupled receptor signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0030073 | Biological process | insulin secretion |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0071651 | Biological process | positive regulation of chemokine (C-C motif) ligand 5 production |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005576 | Cellular component | extracellular region |
| GO_0043204 | Cellular component | perikaryon |
| GO_0043005 | Cellular component | neuron projection |
| GO_0051428 | Molecular function | peptide hormone receptor binding |
| GO_0016521 | Molecular function | pituitary adenylate cyclase activating polypeptide activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005184 | Molecular function | neuropeptide hormone activity |
| Gene name | ADCYAP1 |
| Protein name | Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] Pituitary adenylate cyclase-activating polypeptide Testis specific of PACAP |
| Synonyms | |
| Description | FUNCTION: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). . |
| Accessions | D6RU84 Q53BH1 ENST00000450565.8 ENST00000579794.1 P18509 |
