THPO | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of THPO at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	1256.14	226 / 226	94%	16.93	380 / 406
brain	92%	197.52	2442 / 2642	79%	1.72	554 / 705
breast	98%	103.97	451 / 459	60%	4.26	671 / 1118
kidney	100%	252.87	89 / 89	41%	2.84	371 / 901
prostate	97%	95.76	237 / 245	34%	0.77	169 / 502
lung	92%	60.30	532 / 578	30%	1.99	348 / 1155
uterus	99%	298.31	169 / 170	19%	0.92	87 / 459
adrenal gland	100%	167.54	257 / 258	7%	0.30	15 / 230
ovary	100%	190.60	180 / 180	6%	0.13	25 / 430
adipose	100%	119.31	1199 / 1204	0%	0	0 / 0
spleen	99%	91.05	239 / 241	0%	0	0 / 0
bladder	90%	68.29	19 / 21	6%	0.35	29 / 504
muscle	96%	80.14	769 / 803	0%	0	0 / 0
thymus	93%	59.53	606 / 653	0%	0.00	2 / 605
pancreas	70%	66.71	230 / 328	21%	0.37	38 / 178
intestine	82%	48.59	790 / 966	5%	0.35	26 / 527
heart	86%	49.09	741 / 861	0%	0	0 / 0
blood vessel	83%	53.22	1110 / 1335	0%	0	0 / 0
esophagus	74%	58.69	1070 / 1445	7%	0.48	12 / 183
stomach	72%	50.10	257 / 359	8%	0.67	24 / 286
skin	49%	25.11	884 / 1809	8%	0.42	37 / 472
lymph node	0%	0	0 / 0	10%	0.46	3 / 29
tonsil	0%	0	0 / 0	4%	0.22	2 / 45
peripheral blood	1%	1.24	12 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_1902035	Biological process	positive regulation of hematopoietic stem cell proliferation
GO_0035855	Biological process	megakaryocyte development
GO_0045654	Biological process	positive regulation of megakaryocyte differentiation
GO_0030219	Biological process	megakaryocyte differentiation
GO_0008283	Biological process	cell population proliferation
GO_0038163	Biological process	thrombopoietin-mediated signaling pathway
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0097696	Biological process	cell surface receptor signaling pathway via STAT
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005179	Molecular function	hormone activity
GO_0005102	Molecular function	signaling receptor binding
GO_0005125	Molecular function	cytokine activity
GO_0008083	Molecular function	growth factor activity

Gene name	THPO
Protein name	Thrombopoietin nirs variant 2 Thrombopoietin (C-mpl ligand) (ML) (Megakaryocyte colony-stimulating factor) (Megakaryocyte growth and development factor) (MGDF) (Myeloproliferative leukemia virus oncogene ligand) Thrombopoietin nirs variant 3 Thrombopoietin
Synonyms	hCG_40497 MGDF
Description	FUNCTION: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Accessions	ENST00000649095.1 ENST00000645603.2 P40225 ENST00000477594.1 ENST00000650229.1 ENST00000647395.1 [P40225-1] ENST00000445696.6 [P40225-2] A0A3B3ITS0 ENST00000421442.2 Q5FBX6 Q5FBX8 Q5FBX4 A0A2R8Y734 F8W6L1

THPO report