FGF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	13 studies	31% ± 15%	Explore
oligodendrocyte	13 studies	34% ± 14%	Explore
adipocyte	7 studies	19% ± 2%	Explore
pericyte	7 studies	28% ± 5%	Explore
Mueller cell	5 studies	23% ± 5%	Explore
podocyte	4 studies	71% ± 18%	Explore
smooth muscle cell	4 studies	26% ± 12%	Explore
endothelial cell	3 studies	34% ± 6%	Explore
cardiac muscle cell	3 studies	23% ± 3%	Explore
retinal cone cell	3 studies	55% ± 17%	Explore
retinal rod cell	3 studies	48% ± 19%	Explore
mesothelial cell	3 studies	30% ± 10%	Explore
GABAergic neuron	3 studies	35% ± 3%	Explore
glutamatergic neuron	3 studies	35% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	33% ± 13%	Explore
eye	4 studies	29% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	16740.88	2642 / 2642	100%	140.77	703 / 705
kidney	91%	8970.46	81 / 89	40%	3.94	362 / 901
breast	20%	418.93	93 / 459	83%	10.18	926 / 1118
thymus	3%	43.18	17 / 653	82%	9.25	494 / 605
blood vessel	78%	2825.84	1036 / 1335	0%	0	0 / 0
heart	70%	1817.64	606 / 861	0%	0	0 / 0
skin	11%	194.42	193 / 1809	52%	8.18	247 / 472
adrenal gland	0%	11.94	1 / 258	60%	19.88	137 / 230
pancreas	0%	0	0 / 328	59%	4.84	105 / 178
tonsil	0%	0	0 / 0	51%	5.84	23 / 45
adipose	33%	1438.96	398 / 1204	0%	0	0 / 0
lung	1%	16.14	5 / 578	31%	2.19	359 / 1155
esophagus	1%	13.88	10 / 1445	26%	1.84	48 / 183
uterus	1%	11.21	1 / 170	21%	1.45	98 / 459
ovary	0%	0	0 / 180	20%	1.17	84 / 430
prostate	0%	0	0 / 245	17%	0.79	84 / 502
bladder	0%	0	0 / 21	12%	0.77	60 / 504
eye	0%	0	0 / 0	11%	0.96	9 / 80
liver	0%	0	0 / 226	10%	0.86	39 / 406
intestine	2%	25.41	16 / 966	7%	0.54	38 / 527
stomach	0%	0	0 / 359	7%	0.29	19 / 286
spleen	2%	23.06	4 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050673	Biological process	epithelial cell proliferation
GO_0001525	Biological process	angiogenesis
GO_0051781	Biological process	positive regulation of cell division
GO_2000347	Biological process	positive regulation of hepatocyte proliferation
GO_0030324	Biological process	lung development
GO_1901509	Biological process	regulation of endothelial tube morphogenesis
GO_0001759	Biological process	organ induction
GO_0032148	Biological process	activation of protein kinase B activity
GO_0034605	Biological process	cellular response to heat
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0009887	Biological process	animal organ morphogenesis
GO_0007165	Biological process	signal transduction
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0010628	Biological process	positive regulation of gene expression
GO_1902533	Biological process	positive regulation of intracellular signal transduction
GO_1903672	Biological process	positive regulation of sprouting angiogenesis
GO_0060681	Biological process	branch elongation involved in ureteric bud branching
GO_0042060	Biological process	wound healing
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0030335	Biological process	positive regulation of cell migration
GO_0072163	Biological process	mesonephric epithelium development
GO_0030154	Biological process	cell differentiation
GO_0030334	Biological process	regulation of cell migration
GO_0009653	Biological process	anatomical structure morphogenesis
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_2000544	Biological process	regulation of endothelial cell chemotaxis to fibroblast growth factor
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0045542	Biological process	positive regulation of cholesterol biosynthetic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005654	Cellular component	nucleoplasm
GO_0031012	Cellular component	extracellular matrix
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0008201	Molecular function	heparin binding
GO_0008083	Molecular function	growth factor activity
GO_0005178	Molecular function	integrin binding
GO_0005104	Molecular function	fibroblast growth factor receptor binding
GO_0030544	Molecular function	Hsp70 protein binding
GO_0044548	Molecular function	S100 protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	FGF1
Protein name	Fibroblast growth factor 1 Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1) Alternative protein FGF1
Synonyms	FGFA
Description	FUNCTION: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 . Can induce angiogenesis . .
Accessions	ENST00000419524.6 [P05230-1] ENST00000610990.4 [P05230-1] ENST00000407758.5 ENST00000621536.4 [P05230-1] C9JDC5 ENST00000394496.2 ENST00000337706.7 [P05230-1] ENST00000441680.6 [P05230-1] B5MCF4 L8ECL8 ENST00000612258.4 [P05230-1] P05230 ENST00000619447.4 [P05230-1] ENST00000378046.5 [P05230-1] ENST00000411960.1 ENST00000359370.10 [P05230-1] ENST00000360966.9 [P05230-2] C9JUP6

FGF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review