Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal rod cell | 7 studies | 35% ± 17% | |
| type I pneumocyte | 6 studies | 22% ± 4% | |
| retinal cone cell | 6 studies | 34% ± 7% | |
| retinal bipolar neuron | 3 studies | 21% ± 5% | |
| extravillous trophoblast | 3 studies | 34% ± 15% | |
| rod bipolar cell | 3 studies | 22% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| eye | 4 studies | 33% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 3760.64 | 652 / 653 | 100% | 14.42 | 602 / 605 |
| pancreas | 99% | 1888.28 | 324 / 328 | 100% | 13.63 | 178 / 178 |
| lung | 100% | 4826.12 | 578 / 578 | 97% | 11.08 | 1126 / 1155 |
| breast | 98% | 1897.42 | 449 / 459 | 96% | 7.58 | 1068 / 1118 |
| prostate | 97% | 2364.82 | 237 / 245 | 94% | 5.22 | 471 / 502 |
| adrenal gland | 93% | 1320.18 | 240 / 258 | 97% | 9.85 | 223 / 230 |
| kidney | 100% | 2113.34 | 89 / 89 | 87% | 5.82 | 786 / 901 |
| esophagus | 86% | 1731.11 | 1241 / 1445 | 98% | 11.40 | 179 / 183 |
| stomach | 85% | 1258.31 | 306 / 359 | 97% | 8.57 | 276 / 286 |
| intestine | 80% | 2246.30 | 770 / 966 | 98% | 9.04 | 517 / 527 |
| skin | 83% | 2136.21 | 1495 / 1809 | 94% | 9.38 | 446 / 472 |
| bladder | 71% | 1166.67 | 15 / 21 | 97% | 9.38 | 488 / 504 |
| brain | 84% | 1940.78 | 2223 / 2642 | 77% | 3.75 | 546 / 705 |
| uterus | 50% | 574.01 | 85 / 170 | 95% | 13.56 | 438 / 459 |
| liver | 64% | 698.19 | 144 / 226 | 70% | 3.83 | 285 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 25.79 | 29 / 29 |
| spleen | 100% | 11670.99 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 14.45 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.13 | 1 / 1 |
| peripheral blood | 100% | 14542.31 | 926 / 929 | 0% | 0 | 0 / 0 |
| adipose | 95% | 1750.45 | 1146 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 85% | 1633.54 | 679 / 803 | 0% | 0 | 0 / 0 |
| ovary | 9% | 82.75 | 17 / 180 | 70% | 3.73 | 303 / 430 |
| eye | 0% | 0 | 0 / 0 | 55% | 3.99 | 44 / 80 |
| heart | 51% | 501.08 | 435 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 42% | 508.56 | 556 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0050766 | Biological process | positive regulation of phagocytosis |
| GO_0018149 | Biological process | peptide cross-linking |
| GO_0055085 | Biological process | transmembrane transport |
| GO_1902430 | Biological process | negative regulation of amyloid-beta formation |
| GO_0045806 | Biological process | negative regulation of endocytosis |
| GO_0019216 | Biological process | regulation of lipid metabolic process |
| GO_0033700 | Biological process | phospholipid efflux |
| GO_1901076 | Biological process | positive regulation of engulfment of apoptotic cell |
| GO_2000010 | Biological process | positive regulation of protein localization to cell surface |
| GO_0008542 | Biological process | visual learning |
| GO_0044857 | Biological process | plasma membrane raft organization |
| GO_0034380 | Biological process | high-density lipoprotein particle assembly |
| GO_0038027 | Biological process | apolipoprotein A-I-mediated signaling pathway |
| GO_1900223 | Biological process | positive regulation of amyloid-beta clearance |
| GO_1902995 | Biological process | positive regulation of phospholipid efflux |
| GO_0034504 | Biological process | protein localization to nucleus |
| GO_0150094 | Biological process | amyloid-beta clearance by cellular catabolic process |
| GO_0010875 | Biological process | positive regulation of cholesterol efflux |
| GO_0045332 | Biological process | phospholipid translocation |
| GO_0006909 | Biological process | phagocytosis |
| GO_0043409 | Biological process | negative regulation of MAPK cascade |
| GO_0042985 | Biological process | negative regulation of amyloid precursor protein biosynthetic process |
| GO_1903898 | Biological process | negative regulation of PERK-mediated unfolded protein response |
| GO_0007613 | Biological process | memory |
| GO_0033344 | Biological process | cholesterol efflux |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_1902991 | Biological process | regulation of amyloid precursor protein catabolic process |
| GO_0034205 | Biological process | amyloid-beta formation |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0009986 | Cellular component | cell surface |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0001891 | Cellular component | phagocytic cup |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030054 | Cellular component | cell junction |
| GO_0097386 | Cellular component | glial cell projection |
| GO_0034188 | Molecular function | apolipoprotein A-I receptor activity |
| GO_0090556 | Molecular function | phosphatidylserine floppase activity |
| GO_0090554 | Molecular function | phosphatidylcholine floppase activity |
| GO_0140359 | Molecular function | ABC-type transporter activity |
| GO_0005548 | Molecular function | phospholipid transporter activity |
| GO_0140328 | Molecular function | floppase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0042626 | Molecular function | ATPase-coupled transmembrane transporter activity |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | ABCA7 |
| Protein name | ATP binding cassette subfamily A member 7 Alternative protein ABCA7 Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP . Transports preferentially phosphatidylserine over phosphatidylcholine . Plays a role in lipid homeostasis and macrophage-mediated phagocytosis . Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells . May also mediate cholesterol efflux . May regulate cellular ceramide homeostasis during keratinocyte differentiation . Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing . Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients . . |
| Accessions | A0A6E1ZGS3 Q8IZY2 A0A087WX86 E9PKG5 H0YF58 ENST00000525073.6 ENST00000524850.5 E9PL63 H0YCN5 L8EB07 A0A087WZX6 ENST00000612569.1 ENST00000530092.2 ENST00000529442.7 ENST00000531467.5 ENST00000263094.11 [Q8IZY2-1] ENST00000435683.7 |
