RAP1A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	46 studies	33% ± 13%	Explore
macrophage	43 studies	40% ± 13%	Explore
natural killer cell	36 studies	30% ± 7%	Explore
CD4-positive, alpha-beta T cell	34 studies	34% ± 9%	Explore
CD8-positive, alpha-beta T cell	34 studies	31% ± 9%	Explore
B cell	33 studies	25% ± 6%	Explore
T cell	31 studies	32% ± 10%	Explore
pericyte	29 studies	26% ± 8%	Explore
smooth muscle cell	28 studies	29% ± 9%	Explore
fibroblast	28 studies	25% ± 10%	Explore
regulatory T cell	26 studies	44% ± 12%	Explore
conventional dendritic cell	25 studies	42% ± 14%	Explore
non-classical monocyte	23 studies	40% ± 13%	Explore
classical monocyte	23 studies	39% ± 11%	Explore
monocyte	21 studies	40% ± 13%	Explore
mast cell	20 studies	27% ± 9%	Explore
endothelial cell of lymphatic vessel	20 studies	35% ± 11%	Explore
dendritic cell	19 studies	43% ± 19%	Explore
memory B cell	17 studies	25% ± 5%	Explore
mature NK T cell	17 studies	31% ± 7%	Explore
microglial cell	17 studies	50% ± 18%	Explore
oligodendrocyte	16 studies	38% ± 15%	Explore
gamma-delta T cell	16 studies	32% ± 9%	Explore
naive B cell	15 studies	22% ± 6%	Explore
capillary endothelial cell	15 studies	24% ± 6%	Explore
myeloid cell	15 studies	43% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	29% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	32% ± 7%	Explore
endothelial cell of vascular tree	14 studies	29% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	31% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	35% ± 8%	Explore
endothelial cell of artery	12 studies	26% ± 7%	Explore
vein endothelial cell	12 studies	27% ± 13%	Explore
mucosal invariant T cell	12 studies	29% ± 6%	Explore
leukocyte	11 studies	39% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	33% ± 7%	Explore
type II pneumocyte	10 studies	32% ± 13%	Explore
plasma cell	10 studies	29% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	38% ± 12%	Explore
type I pneumocyte	9 studies	31% ± 8%	Explore
plasmablast	9 studies	32% ± 18%	Explore
plasmacytoid dendritic cell	9 studies	27% ± 10%	Explore
glutamatergic neuron	9 studies	39% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	34% ± 6%	Explore
myofibroblast cell	9 studies	26% ± 8%	Explore
epithelial cell	9 studies	38% ± 17%	Explore
astrocyte	9 studies	29% ± 12%	Explore
oligodendrocyte precursor cell	9 studies	28% ± 12%	Explore
alveolar macrophage	8 studies	38% ± 10%	Explore
connective tissue cell	8 studies	24% ± 8%	Explore
T follicular helper cell	8 studies	45% ± 8%	Explore
GABAergic neuron	8 studies	38% ± 19%	Explore
adipocyte	8 studies	23% ± 6%	Explore
neutrophil	7 studies	25% ± 6%	Explore
mononuclear phagocyte	7 studies	49% ± 11%	Explore
goblet cell	7 studies	35% ± 19%	Explore
basal cell	7 studies	33% ± 13%	Explore
club cell	7 studies	22% ± 6%	Explore
platelet	6 studies	23% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	35% ± 9%	Explore
lymphocyte	6 studies	42% ± 16%	Explore
innate lymphoid cell	6 studies	30% ± 3%	Explore
retina horizontal cell	6 studies	24% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	39% ± 14%	Explore
kidney loop of Henle epithelial cell	5 studies	22% ± 3%	Explore
glial cell	5 studies	26% ± 11%	Explore
cardiac muscle cell	5 studies	30% ± 7%	Explore
ciliated cell	5 studies	27% ± 8%	Explore
respiratory goblet cell	4 studies	19% ± 4%	Explore
exhausted T cell	4 studies	39% ± 6%	Explore
neuron	4 studies	35% ± 17%	Explore
megakaryocyte	4 studies	33% ± 14%	Explore
retinal cone cell	4 studies	31% ± 9%	Explore
mucus secreting cell	4 studies	21% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	38% ± 8%	Explore
intermediate monocyte	4 studies	51% ± 18%	Explore
CD4-positive helper T cell	4 studies	30% ± 10%	Explore
hepatocyte	4 studies	42% ± 25%	Explore
granulocyte	4 studies	30% ± 12%	Explore
abnormal cell	4 studies	27% ± 11%	Explore
enteroendocrine cell	4 studies	24% ± 8%	Explore
T-helper 17 cell	4 studies	44% ± 6%	Explore
interneuron	4 studies	48% ± 23%	Explore
T-helper 1 cell	4 studies	49% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	34% ± 10%	Explore
secretory cell	4 studies	27% ± 7%	Explore
pancreatic A cell	3 studies	33% ± 16%	Explore
hematopoietic precursor cell	3 studies	38% ± 6%	Explore
glomerular endothelial cell	3 studies	22% ± 2%	Explore
GABAergic interneuron	3 studies	22% ± 4%	Explore
enterocyte	3 studies	19% ± 2%	Explore
tissue-resident macrophage	3 studies	39% ± 12%	Explore
intraepithelial lymphocyte	3 studies	32% ± 10%	Explore
Mueller cell	3 studies	20% ± 3%	Explore
germinal center B cell	3 studies	31% ± 2%	Explore
inflammatory macrophage	3 studies	31% ± 5%	Explore
muscle cell	3 studies	44% ± 14%	Explore
hematopoietic stem cell	3 studies	25% ± 5%	Explore
adventitial cell	3 studies	18% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 11%	Explore
Schwann cell	3 studies	36% ± 14%	Explore
granule cell	3 studies	22% ± 3%	Explore
erythrocyte	3 studies	33% ± 20%	Explore
immature B cell	3 studies	18% ± 0%	Explore
mural cell	3 studies	42% ± 15%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	29% ± 8%	Explore
brain	18 studies	33% ± 19%	Explore
peripheral blood	15 studies	34% ± 9%	Explore
intestine	10 studies	22% ± 8%	Explore
kidney	6 studies	24% ± 7%	Explore
lymph node	5 studies	29% ± 9%	Explore
heart	5 studies	27% ± 5%	Explore
liver	5 studies	40% ± 18%	Explore
bone marrow	4 studies	25% ± 6%	Explore
uterus	4 studies	24% ± 6%	Explore
breast	4 studies	20% ± 3%	Explore
adipose	4 studies	28% ± 2%	Explore
pancreas	3 studies	31% ± 18%	Explore
eye	3 studies	28% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	4683.71	459 / 459	100%	45.00	1118 / 1118
esophagus	100%	9752.91	1445 / 1445	100%	35.96	183 / 183
ovary	100%	3294.01	180 / 180	100%	32.28	430 / 430
lung	100%	5884.37	577 / 578	100%	43.19	1155 / 1155
uterus	100%	4835.30	170 / 170	100%	45.10	458 / 459
kidney	100%	3499.38	89 / 89	100%	42.29	898 / 901
prostate	100%	5193.49	244 / 245	100%	43.21	502 / 502
brain	99%	3697.04	2626 / 2642	100%	48.95	705 / 705
thymus	100%	4288.93	651 / 653	100%	53.59	603 / 605
bladder	100%	9025.57	21 / 21	99%	39.03	500 / 504
intestine	100%	10283.52	966 / 966	99%	36.16	522 / 527
adrenal gland	100%	3699.27	258 / 258	99%	29.04	227 / 230
stomach	99%	5698.97	356 / 359	99%	38.77	283 / 286
skin	99%	3029.41	1783 / 1809	97%	42.19	456 / 472
liver	95%	2120.51	214 / 226	99%	26.85	403 / 406
pancreas	61%	1048.33	201 / 328	98%	42.00	175 / 178
blood vessel	100%	10902.78	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	82.68	29 / 29
spleen	100%	5225.31	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	39.99	45 / 45
ureter	0%	0	0 / 0	100%	12.21	1 / 1
adipose	100%	5712.38	1203 / 1204	0%	0	0 / 0
muscle	99%	4632.96	798 / 803	0%	0	0 / 0
heart	96%	3874.01	830 / 861	0%	0	0 / 0
peripheral blood	96%	6993.24	895 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	81%	13.83	65 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000301	Biological process	negative regulation of synaptic vesicle exocytosis
GO_0072659	Biological process	protein localization to plasma membrane
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0043547	Biological process	positive regulation of GTPase activity
GO_1901888	Biological process	regulation of cell junction assembly
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0038180	Biological process	nerve growth factor signaling pathway
GO_0045860	Biological process	positive regulation of protein kinase activity
GO_0030033	Biological process	microvillus assembly
GO_0032486	Biological process	Rap protein signal transduction
GO_0071320	Biological process	cellular response to cAMP
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_2001214	Biological process	positive regulation of vasculogenesis
GO_0098696	Biological process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0061028	Biological process	establishment of endothelial barrier
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0007399	Biological process	nervous system development
GO_0098978	Cellular component	glutamatergic synapse
GO_0098793	Cellular component	presynapse
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0032045	Cellular component	guanyl-nucleotide exchange factor complex
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005769	Cellular component	early endosome
GO_0070062	Cellular component	extracellular exosome
GO_0043005	Cellular component	neuron projection
GO_0005829	Cellular component	cytosol
GO_0070161	Cellular component	anchoring junction
GO_0005770	Cellular component	late endosome
GO_0005737	Cellular component	cytoplasm
GO_0030054	Cellular component	cell junction
GO_0097225	Cellular component	sperm midpiece
GO_0010008	Cellular component	endosome membrane
GO_0019003	Molecular function	GDP binding
GO_0005085	Molecular function	guanyl-nucleotide exchange factor activity
GO_0044877	Molecular function	protein-containing complex binding
GO_0003925	Molecular function	G protein activity
GO_0031267	Molecular function	small GTPase binding
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RAP1A
Protein name	small monomeric GTPase (EC 3.6.5.2) Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)
Synonyms	KREV1 hCG_1818872
Description	FUNCTION: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. .
Accessions	ENST00000687939.1 ENST00000356415.5 ENST00000369709.4 P62834 A8KAH9

RAP1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review