NTRK1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NTRK1 at tissue level.

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0048013Biological processephrin receptor signaling pathway
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0048485Biological processsympathetic nervous system development
GO_0010976Biological processpositive regulation of neuron projection development
GO_0043547Biological processpositive regulation of GTPase activity
GO_0060009Biological processSertoli cell development
GO_0007611Biological processlearning or memory
GO_0048011Biological processneurotrophin TRK receptor signaling pathway
GO_0051602Biological processresponse to electrical stimulus
GO_0051599Biological processresponse to hydrostatic pressure
GO_0048678Biological processresponse to axon injury
GO_0007275Biological processmulticellular organism development
GO_0050966Biological processdetection of mechanical stimulus involved in sensory perception of pain
GO_0060385Biological processaxonogenesis involved in innervation
GO_0061368Biological processbehavioral response to formalin induced pain
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0038180Biological processnerve growth factor signaling pathway
GO_0007623Biological processcircadian rhythm
GO_0038083Biological processpeptidyl-tyrosine autophosphorylation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0033674Biological processpositive regulation of kinase activity
GO_0031667Biological processresponse to nutrient levels
GO_0010623Biological processprogrammed cell death involved in cell development
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0051402Biological processneuron apoptotic process
GO_0042490Biological processmechanoreceptor differentiation
GO_0021553Biological processolfactory nerve development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043068Biological processpositive regulation of programmed cell death
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_1990090Biological processcellular response to nerve growth factor stimulus
GO_0046579Biological processpositive regulation of Ras protein signal transduction
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0051968Biological processpositive regulation of synaptic transmission, glutamatergic
GO_0071316Biological processcellular response to nicotine
GO_0006468Biological processprotein phosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0046777Biological processprotein autophosphorylation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0051965Biological processpositive regulation of synapse assembly
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1904646Biological processcellular response to amyloid-beta
GO_0030183Biological processB cell differentiation
GO_0007411Biological processaxon guidance
GO_0031902Cellular componentlate endosome membrane
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0032991Cellular componentprotein-containing complex
GO_0055038Cellular componentrecycling endosome membrane
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0005770Cellular componentlate endosome
GO_0010008Cellular componentendosome membrane
GO_0030424Cellular componentaxon
GO_0042803Molecular functionprotein homodimerization activity
GO_0005004Molecular functionGPI-linked ephrin receptor activity
GO_0010465Molecular functionnerve growth factor receptor activity
GO_0019900Molecular functionkinase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0005166Molecular functionneurotrophin p75 receptor binding
GO_0005030Molecular functionneurotrophin receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0043121Molecular functionneurotrophin binding
GO_0005524Molecular functionATP binding
GO_0048406Molecular functionnerve growth factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNTRK1
Protein nameNeurotrophic receptor tyrosine kinase 1
High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
Tyrosine-protein kinase receptor (EC 2.7.10.1)
SynonymsMTC
TRK
TRKA
DescriptionFUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand . Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation . Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. .; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. .

AccessionsA0A6Q8PHG5
A0A6Q8PF65
ENST00000674537.2
ENST00000368196.7 [P04629-2]
ENST00000358660.3
X5DR71
ENST00000392302.7
ENST00000675461.1
ENST00000531606.2
ENST00000497019.7
A0A6Q8PGU5
X5D991
E9PQG0
ENST00000524377.7 [P04629-1]
J3KP20
P04629