PDE8A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019933Biological processcAMP-mediated signaling
GO_0006198Biological processcAMP catabolic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0006355Biological processregulation of DNA-templated transcription
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005634Cellular componentnucleus
GO_0019900Molecular functionkinase binding
GO_0030295Molecular functionprotein kinase activator activity
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePDE8A
Protein namePhosphodiesterase 8A
PDE8A protein
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)
Synonyms
DescriptionFUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development . Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling . Protects against cell death induced by hydrogen peroxide and staurosporine . .

AccessionsENST00000339708.9 [O60658-2]
ENST00000310298.8 [O60658-1]
O60658
E9PIJ0
ENST00000478717.5 [O60658-4]
ENST00000485596.5
ENST00000559742.5
ENST00000557957.5 [O60658-6]
ENST00000559086.5
Q86XV4
H0YKR1
H0YNP3
ENST00000394553.6 [O60658-1]