Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 24 studies | 40% ± 16% | |
| astrocyte | 16 studies | 34% ± 17% | |
| oligodendrocyte | 16 studies | 70% ± 21% | |
| oligodendrocyte precursor cell | 13 studies | 32% ± 14% | |
| microglial cell | 13 studies | 38% ± 15% | |
| pericyte | 13 studies | 48% ± 20% | |
| fibroblast | 13 studies | 32% ± 14% | |
| macrophage | 12 studies | 37% ± 18% | |
| adipocyte | 9 studies | 44% ± 8% | |
| mast cell | 9 studies | 27% ± 10% | |
| smooth muscle cell | 9 studies | 30% ± 14% | |
| GABAergic neuron | 8 studies | 46% ± 23% | |
| myeloid cell | 7 studies | 35% ± 15% | |
| glutamatergic neuron | 6 studies | 45% ± 25% | |
| epithelial cell | 6 studies | 34% ± 16% | |
| endothelial cell of lymphatic vessel | 6 studies | 37% ± 14% | |
| cardiac muscle cell | 5 studies | 35% ± 11% | |
| dendritic cell | 5 studies | 25% ± 4% | |
| monocyte | 5 studies | 35% ± 11% | |
| type I pneumocyte | 5 studies | 27% ± 6% | |
| type II pneumocyte | 5 studies | 34% ± 5% | |
| mesothelial cell | 4 studies | 26% ± 11% | |
| respiratory goblet cell | 4 studies | 35% ± 11% | |
| club cell | 4 studies | 31% ± 7% | |
| basal cell | 4 studies | 32% ± 18% | |
| interneuron | 4 studies | 48% ± 21% | |
| cholangiocyte | 3 studies | 49% ± 21% | |
| hepatic stellate cell | 3 studies | 48% ± 22% | |
| neuron | 3 studies | 55% ± 28% | |
| GABAergic interneuron | 3 studies | 31% ± 2% | |
| glial cell | 3 studies | 35% ± 13% | |
| vein endothelial cell | 3 studies | 41% ± 20% | |
| ciliated cell | 3 studies | 20% ± 4% | |
| retinal rod cell | 3 studies | 55% ± 12% | |
| endothelial cell of vascular tree | 3 studies | 38% ± 17% | |
| hepatocyte | 3 studies | 64% ± 18% | |
| retinal pigment epithelial cell | 3 studies | 36% ± 23% | |
| connective tissue cell | 3 studies | 27% ± 7% | |
| T cell | 3 studies | 20% ± 2% | |
| alveolar macrophage | 3 studies | 52% ± 9% | |
| capillary endothelial cell | 3 studies | 27% ± 6% | |
| muscle cell | 3 studies | 40% ± 28% | |
| transit amplifying cell | 3 studies | 39% ± 26% | |
| mucus secreting cell | 3 studies | 24% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2371.76 | 1443 / 1445 | 100% | 20.51 | 183 / 183 |
| kidney | 100% | 3493.37 | 89 / 89 | 100% | 21.11 | 899 / 901 |
| stomach | 100% | 2597.30 | 359 / 359 | 100% | 17.58 | 285 / 286 |
| intestine | 100% | 4158.99 | 966 / 966 | 100% | 16.54 | 525 / 527 |
| lung | 100% | 3643.70 | 578 / 578 | 99% | 13.16 | 1148 / 1155 |
| pancreas | 100% | 1977.83 | 328 / 328 | 99% | 15.30 | 176 / 178 |
| breast | 100% | 3348.14 | 459 / 459 | 99% | 11.33 | 1102 / 1118 |
| liver | 100% | 3010.35 | 226 / 226 | 99% | 12.18 | 400 / 406 |
| bladder | 100% | 3184.86 | 21 / 21 | 98% | 11.95 | 494 / 504 |
| prostate | 100% | 2838.58 | 245 / 245 | 98% | 8.69 | 491 / 502 |
| skin | 100% | 2162.49 | 1808 / 1809 | 97% | 16.57 | 460 / 472 |
| thymus | 100% | 2601.06 | 652 / 653 | 98% | 10.85 | 590 / 605 |
| uterus | 100% | 2951.62 | 170 / 170 | 97% | 11.73 | 446 / 459 |
| adrenal gland | 100% | 5553.69 | 258 / 258 | 97% | 13.83 | 223 / 230 |
| ovary | 100% | 3131.18 | 180 / 180 | 92% | 7.07 | 395 / 430 |
| brain | 94% | 2610.97 | 2471 / 2642 | 96% | 17.98 | 676 / 705 |
| adipose | 100% | 4112.75 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2487.50 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.01 | 1 / 1 |
| blood vessel | 100% | 2721.40 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 1895.22 | 858 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 9.60 | 44 / 45 |
| muscle | 98% | 1088.48 | 785 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 13.78 | 77 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 69% | 4.00 | 20 / 29 |
| peripheral blood | 41% | 871.75 | 383 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0019933 | Biological process | cAMP-mediated signaling |
| GO_0006198 | Biological process | cAMP catabolic process |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0071364 | Biological process | cellular response to epidermal growth factor stimulus |
| GO_0006355 | Biological process | regulation of DNA-templated transcription |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0019900 | Molecular function | kinase binding |
| GO_0030295 | Molecular function | protein kinase activator activity |
| GO_0047555 | Molecular function | 3',5'-cyclic-GMP phosphodiesterase activity |
| GO_0004115 | Molecular function | 3',5'-cyclic-AMP phosphodiesterase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | PDE8A |
| Protein name | Phosphodiesterase 8A PDE8A protein High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53) |
| Synonyms | |
| Description | FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes . May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development . Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling . Protects against cell death induced by hydrogen peroxide and staurosporine . . |
| Accessions | ENST00000339708.9 [O60658-2] ENST00000310298.8 [O60658-1] O60658 E9PIJ0 ENST00000478717.5 [O60658-4] ENST00000485596.5 ENST00000559742.5 ENST00000557957.5 [O60658-6] ENST00000559086.5 Q86XV4 H0YKR1 H0YNP3 ENST00000394553.6 [O60658-1] |