PTPN11 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	15 studies	26% ± 9%	Explore
oligodendrocyte	12 studies	37% ± 20%	Explore
glutamatergic neuron	10 studies	40% ± 28%	Explore
endothelial cell of lymphatic vessel	8 studies	23% ± 6%	Explore
fibroblast	8 studies	19% ± 7%	Explore
epithelial cell	7 studies	32% ± 14%	Explore
GABAergic neuron	7 studies	43% ± 26%	Explore
astrocyte	7 studies	34% ± 25%	Explore
natural killer cell	6 studies	18% ± 3%	Explore
microglial cell	6 studies	32% ± 27%	Explore
adipocyte	6 studies	21% ± 3%	Explore
oligodendrocyte precursor cell	6 studies	24% ± 9%	Explore
smooth muscle cell	5 studies	18% ± 2%	Explore
type I pneumocyte	5 studies	21% ± 4%	Explore
neuron	5 studies	29% ± 13%	Explore
Mueller cell	5 studies	19% ± 4%	Explore
macrophage	5 studies	22% ± 3%	Explore
interneuron	5 studies	46% ± 31%	Explore
basal cell	4 studies	28% ± 10%	Explore
cardiac muscle cell	4 studies	18% ± 2%	Explore
lymphocyte	4 studies	21% ± 4%	Explore
pericyte	4 studies	23% ± 6%	Explore
hematopoietic precursor cell	3 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	3 studies	19% ± 4%	Explore
GABAergic interneuron	3 studies	20% ± 3%	Explore
myeloid cell	3 studies	21% ± 3%	Explore
club cell	3 studies	20% ± 2%	Explore
ciliated cell	3 studies	28% ± 5%	Explore
secretory cell	3 studies	25% ± 7%	Explore
hepatocyte	3 studies	37% ± 25%	Explore
dendritic cell	3 studies	26% ± 11%	Explore
abnormal cell	3 studies	28% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	26% ± 8%	Explore
transit amplifying cell	3 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	3 studies	18% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	33% ± 23%	Explore
lung	4 studies	24% ± 7%	Explore
liver	4 studies	25% ± 9%	Explore
peripheral blood	3 studies	20% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	14064.86	2642 / 2642	100%	157.39	705 / 705
esophagus	100%	7943.45	1444 / 1445	100%	75.07	183 / 183
breast	100%	9509.88	459 / 459	99%	76.43	1109 / 1118
lung	99%	7139.35	573 / 578	100%	62.01	1153 / 1155
intestine	100%	7754.90	966 / 966	99%	61.17	520 / 527
kidney	100%	4605.47	89 / 89	98%	59.50	882 / 901
bladder	100%	9604.67	21 / 21	98%	52.43	493 / 504
thymus	100%	6301.96	652 / 653	98%	59.17	591 / 605
adrenal gland	100%	6821.69	257 / 258	98%	59.94	225 / 230
prostate	100%	6613.72	244 / 245	98%	53.16	490 / 502
stomach	98%	5764.05	353 / 359	99%	64.59	282 / 286
uterus	100%	8665.16	170 / 170	97%	50.98	443 / 459
skin	100%	10135.48	1809 / 1809	96%	65.64	453 / 472
ovary	98%	4715.64	177 / 180	96%	33.65	411 / 430
liver	97%	4237.38	219 / 226	91%	38.13	368 / 406
pancreas	86%	2700.86	283 / 328	98%	47.10	174 / 178
adipose	100%	10420.94	1204 / 1204	0%	0	0 / 0
blood vessel	100%	11952.48	1335 / 1335	0%	0	0 / 0
muscle	100%	12499.00	803 / 803	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	26.45	1 / 1
lymph node	0%	0	0 / 0	97%	47.14	28 / 29
spleen	96%	3242.22	232 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	51.83	43 / 45
heart	91%	5853.40	785 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	86%	35.51	69 / 80
peripheral blood	28%	2504.73	259 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0035265	Biological process	organ growth
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0048013	Biological process	ephrin receptor signaling pathway
GO_0032728	Biological process	positive regulation of interferon-beta production
GO_0006470	Biological process	protein dephosphorylation
GO_0046326	Biological process	positive regulation of glucose import
GO_0060020	Biological process	Bergmann glial cell differentiation
GO_0051463	Biological process	negative regulation of cortisol secretion
GO_0060338	Biological process	regulation of type I interferon-mediated signaling pathway
GO_0007507	Biological process	heart development
GO_0048011	Biological process	neurotrophin TRK receptor signaling pathway
GO_0071364	Biological process	cellular response to epidermal growth factor stimulus
GO_0031295	Biological process	T cell costimulation
GO_0038127	Biological process	ERBB signaling pathway
GO_0035264	Biological process	multicellular organism growth
GO_0060125	Biological process	negative regulation of growth hormone secretion
GO_0048839	Biological process	inner ear development
GO_0035335	Biological process	peptidyl-tyrosine dephosphorylation
GO_0033629	Biological process	negative regulation of cell adhesion mediated by integrin
GO_0046676	Biological process	negative regulation of insulin secretion
GO_0000077	Biological process	DNA damage checkpoint signaling
GO_0048806	Biological process	genitalia development
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0032331	Biological process	negative regulation of chondrocyte differentiation
GO_0032480	Biological process	negative regulation of type I interferon production
GO_0007409	Biological process	axonogenesis
GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_0035855	Biological process	megakaryocyte development
GO_0045931	Biological process	positive regulation of mitotic cell cycle
GO_0061582	Biological process	intestinal epithelial cell migration
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0033628	Biological process	regulation of cell adhesion mediated by integrin
GO_0006641	Biological process	triglyceride metabolic process
GO_0009755	Biological process	hormone-mediated signaling pathway
GO_0036302	Biological process	atrioventricular canal development
GO_0043254	Biological process	regulation of protein-containing complex assembly
GO_0007173	Biological process	epidermal growth factor receptor signaling pathway
GO_0007420	Biological process	brain development
GO_0021697	Biological process	cerebellar cortex formation
GO_0032528	Biological process	microvillus organization
GO_0046628	Biological process	positive regulation of insulin receptor signaling pathway
GO_0048609	Biological process	multicellular organismal reproductive process
GO_0046825	Biological process	regulation of protein export from nucleus
GO_0045778	Biological process	positive regulation of ossification
GO_0046887	Biological process	positive regulation of hormone secretion
GO_0060325	Biological process	face morphogenesis
GO_0042445	Biological process	hormone metabolic process
GO_0030220	Biological process	platelet formation
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0042593	Biological process	glucose homeostasis
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0032991	Cellular component	protein-containing complex
GO_0005634	Cellular component	nucleus
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004726	Molecular function	non-membrane spanning protein tyrosine phosphatase activity
GO_0005158	Molecular function	insulin receptor binding
GO_0004721	Molecular function	phosphoprotein phosphatase activity
GO_0060090	Molecular function	molecular adaptor activity
GO_0051428	Molecular function	peptide hormone receptor binding
GO_0045296	Molecular function	cadherin binding
GO_0019901	Molecular function	protein kinase binding
GO_1990782	Molecular function	protein tyrosine kinase binding
GO_0030159	Molecular function	signaling receptor complex adaptor activity
GO_0050839	Molecular function	cell adhesion molecule binding
GO_0005515	Molecular function	protein binding
GO_0001784	Molecular function	phosphotyrosine residue binding
GO_0030971	Molecular function	receptor tyrosine kinase binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	PTPN11
Protein name	Tyrosine-protein phosphatase non-receptor type (EC 3.1.3.48) Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3) Protein tyrosine phosphatase non-receptor type 11 PTPN11 protein (cDNA, FLJ92431) Protein tyrosine phosphatase non-receptor type 11 isoform 1 protein-tyrosine-phosphatase (EC 3.1.3.48) Protein tyrosine phosphatase-2
Synonyms	PTP2C SHPTP2
Description	FUNCTION: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus . Positively regulates MAPK signal transduction pathway . Dephosphorylates GAB1, ARHGAP35 and EGFR . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity . Dephosphorylates CDC73 . Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L . .
Accessions	A0A8I5KW48 A0A0U1RRI0 A0A8I5KVS6 A0A6C0W5F9 ENST00000351677.7 [Q06124-2] H0YF12 A0A6C0W4X6 A0A6C0W521 A0A6C0W8I3 A0A6C0W4X1 B3GUD3 A0A6C0W5X7 A0A6C0W4U5 A0A8I5KRZ3 A0A6C0W763 ENST00000639857.2 ENST00000692624.1 ENST00000690210.1 ENST00000392597.5 [Q06124-3] A0A3G1LBG2 A0A6C0W513 A0A6C0W5V7 A0A6C0W5F8 A0A6C0W5H1 ENST00000635625.1 [Q06124-1] A0A6C0W4Z3 A0A6C0W5Z9 ENST00000635652.1 A0A6C0W4W9 A0A6C0W5K7 A0A6C0W5J5 B3GUD4 ENST00000530818.1 ENST00000687906.1 A0A6C0W5U2 A0A6C0W4Y0 A0A6C0W501 A0A6C0W5S4 A0A8I5QL30 A0A6C0W611 A0A6C0W636 A0A6C0W8D9 A0A6C0W8E6 A0A6C0W4Z4 Q06124 ENST00000688597.1 B3GUD5 Q96I26 ENST00000685487.1 A0A6C0W750 A0A6C0W5U7 A0A1W2PPU4 A0A8I5QJ58 A0A6C0W4U7

PTPN11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review