APELA report

I. Expression across cell types

Insufficient scRNA-seq data for expression of APELA at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of APELA at tissue level.

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0007507Biological processheart development
GO_0045766Biological processpositive regulation of angiogenesis
GO_1901165Biological processpositive regulation of trophoblast cell migration
GO_0001570Biological processvasculogenesis
GO_0060976Biological processcoronary vasculature development
GO_1904022Biological processpositive regulation of G protein-coupled receptor internalization
GO_0007492Biological processendoderm development
GO_0060674Biological processplacenta blood vessel development
GO_0007512Biological processadult heart development
GO_0035050Biological processembryonic heart tube development
GO_0090133Biological processmesendoderm migration
GO_0045823Biological processpositive regulation of heart contraction
GO_0090134Biological processcell migration involved in mesendoderm migration
GO_0007509Biological processmesoderm migration involved in gastrulation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1903589Biological processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0060183Biological processapelin receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005179Molecular functionhormone activity
GO_0031704Molecular functionapelin receptor binding

IV. Literature review

[source]
Gene nameAPELA
Protein nameApelin receptor early endogenous ligand (Protein Elabela) (ELA) (Protein Toddler)
SynonymsELA
TDL
DescriptionFUNCTION: Endogenous ligand for the apelin receptor (APLNR) . Hormone required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis . Drives internalization of APLNR. Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus. Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity). .

AccessionsENST00000510062.5
ENST00000507152.6
ENST00000515275.1
P0DMC3