RAP1B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	43% ± 16%	Explore
natural killer cell	46 studies	56% ± 19%	Explore
B cell	40 studies	33% ± 12%	Explore
macrophage	38 studies	39% ± 16%	Explore
CD8-positive, alpha-beta T cell	36 studies	45% ± 17%	Explore
fibroblast	34 studies	37% ± 12%	Explore
CD4-positive, alpha-beta T cell	32 studies	44% ± 15%	Explore
pericyte	31 studies	36% ± 14%	Explore
T cell	30 studies	40% ± 11%	Explore
smooth muscle cell	28 studies	32% ± 10%	Explore
classical monocyte	26 studies	42% ± 18%	Explore
conventional dendritic cell	26 studies	36% ± 18%	Explore
regulatory T cell	25 studies	42% ± 7%	Explore
dendritic cell	24 studies	45% ± 20%	Explore
non-classical monocyte	24 studies	66% ± 18%	Explore
mature NK T cell	23 studies	51% ± 14%	Explore
monocyte	20 studies	43% ± 14%	Explore
endothelial cell of lymphatic vessel	20 studies	44% ± 17%	Explore
memory B cell	19 studies	34% ± 7%	Explore
gamma-delta T cell	18 studies	48% ± 15%	Explore
naive B cell	18 studies	30% ± 9%	Explore
mast cell	17 studies	32% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	41% ± 11%	Explore
plasma cell	16 studies	32% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	56% ± 15%	Explore
mucosal invariant T cell	16 studies	44% ± 11%	Explore
plasmacytoid dendritic cell	16 studies	34% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	67% ± 12%	Explore
basal cell	15 studies	37% ± 15%	Explore
capillary endothelial cell	15 studies	36% ± 13%	Explore
connective tissue cell	15 studies	36% ± 13%	Explore
microglial cell	15 studies	34% ± 13%	Explore
epithelial cell	15 studies	41% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	50% ± 13%	Explore
myeloid cell	14 studies	42% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	51% ± 17%	Explore
vein endothelial cell	13 studies	41% ± 19%	Explore
endothelial cell of vascular tree	13 studies	44% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	44% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	51% ± 13%	Explore
myofibroblast cell	12 studies	35% ± 11%	Explore
endothelial cell of artery	12 studies	36% ± 12%	Explore
ciliated cell	12 studies	32% ± 12%	Explore
astrocyte	12 studies	29% ± 10%	Explore
platelet	11 studies	65% ± 18%	Explore
innate lymphoid cell	9 studies	52% ± 14%	Explore
plasmablast	9 studies	46% ± 19%	Explore
leukocyte	9 studies	49% ± 14%	Explore
adipocyte	9 studies	35% ± 10%	Explore
alveolar macrophage	8 studies	45% ± 17%	Explore
club cell	8 studies	29% ± 12%	Explore
secretory cell	8 studies	31% ± 11%	Explore
oligodendrocyte	8 studies	25% ± 7%	Explore
type I pneumocyte	7 studies	28% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	53% ± 17%	Explore
mononuclear phagocyte	7 studies	48% ± 13%	Explore
hematopoietic stem cell	7 studies	51% ± 18%	Explore
mesothelial cell	7 studies	32% ± 14%	Explore
T follicular helper cell	7 studies	38% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	50% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	52% ± 12%	Explore
megakaryocyte	6 studies	87% ± 13%	Explore
lymphocyte	6 studies	56% ± 14%	Explore
precursor B cell	6 studies	36% ± 8%	Explore
abnormal cell	6 studies	33% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	54% ± 13%	Explore
type II pneumocyte	6 studies	25% ± 5%	Explore
oligodendrocyte precursor cell	6 studies	24% ± 9%	Explore
goblet cell	6 studies	36% ± 26%	Explore
CD4-positive helper T cell	5 studies	37% ± 19%	Explore
exhausted T cell	5 studies	55% ± 17%	Explore
neutrophil	5 studies	30% ± 9%	Explore
respiratory goblet cell	5 studies	33% ± 12%	Explore
progenitor cell	5 studies	25% ± 11%	Explore
glial cell	5 studies	27% ± 13%	Explore
pro-B cell	5 studies	41% ± 11%	Explore
retina horizontal cell	5 studies	37% ± 11%	Explore
Mueller cell	5 studies	24% ± 6%	Explore
intermediate monocyte	5 studies	58% ± 24%	Explore
IgA plasma cell	5 studies	29% ± 13%	Explore
neuron	5 studies	33% ± 15%	Explore
GABAergic neuron	5 studies	36% ± 15%	Explore
erythrocyte	5 studies	35% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	43% ± 17%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	36% ± 8%	Explore
hematopoietic precursor cell	4 studies	55% ± 18%	Explore
pancreatic A cell	4 studies	39% ± 11%	Explore
renal alpha-intercalated cell	4 studies	24% ± 4%	Explore
immature B cell	4 studies	33% ± 8%	Explore
retinal pigment epithelial cell	4 studies	39% ± 18%	Explore
retinal rod cell	4 studies	21% ± 3%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 9%	Explore
hepatocyte	4 studies	48% ± 24%	Explore
granulocyte	4 studies	44% ± 8%	Explore
glutamatergic neuron	4 studies	49% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	70% ± 23%	Explore
enteroendocrine cell	4 studies	38% ± 13%	Explore
T-helper 17 cell	4 studies	54% ± 13%	Explore
interneuron	4 studies	36% ± 21%	Explore
T-helper 1 cell	4 studies	55% ± 7%	Explore
double negative thymocyte	4 studies	53% ± 7%	Explore
type B pancreatic cell	3 studies	46% ± 8%	Explore
monocyte-derived dendritic cell	3 studies	50% ± 14%	Explore
glomerular endothelial cell	3 studies	36% ± 8%	Explore
erythroblast	3 studies	51% ± 12%	Explore
brush cell	3 studies	31% ± 8%	Explore
tissue-resident macrophage	3 studies	36% ± 11%	Explore
intraepithelial lymphocyte	3 studies	35% ± 11%	Explore
germinal center B cell	3 studies	53% ± 8%	Explore
IgG plasma cell	3 studies	27% ± 6%	Explore
luminal cell of prostate epithelium	3 studies	32% ± 12%	Explore
muscle cell	3 studies	42% ± 22%	Explore
pancreatic ductal cell	3 studies	57% ± 11%	Explore
enterocyte	3 studies	23% ± 4%	Explore
adventitial cell	3 studies	36% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	61% ± 5%	Explore
transit amplifying cell	3 studies	34% ± 25%	Explore
keratinocyte	3 studies	29% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	41% ± 5%	Explore
myoepithelial cell	3 studies	34% ± 6%	Explore
renal principal cell	3 studies	24% ± 5%	Explore
mural cell	3 studies	48% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	35% ± 15%	Explore
peripheral blood	18 studies	51% ± 14%	Explore
brain	12 studies	29% ± 14%	Explore
intestine	9 studies	29% ± 15%	Explore
kidney	8 studies	26% ± 11%	Explore
eye	7 studies	28% ± 15%	Explore
heart	5 studies	24% ± 5%	Explore
uterus	5 studies	33% ± 11%	Explore
breast	5 studies	30% ± 10%	Explore
liver	5 studies	45% ± 18%	Explore
pancreas	4 studies	41% ± 13%	Explore
bone marrow	4 studies	42% ± 18%	Explore
prostate	4 studies	29% ± 14%	Explore
lymph node	4 studies	41% ± 6%	Explore
adipose	4 studies	40% ± 9%	Explore
skin	3 studies	29% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2788.17	1445 / 1445	100%	15.31	183 / 183
lung	100%	4825.48	578 / 578	100%	12.59	1154 / 1155
breast	100%	4372.41	459 / 459	100%	10.70	1116 / 1118
intestine	100%	3518.35	966 / 966	100%	10.31	526 / 527
bladder	100%	3426.14	21 / 21	100%	9.92	503 / 504
uterus	100%	3244.32	170 / 170	100%	9.15	458 / 459
ovary	100%	2300.34	180 / 180	100%	12.26	429 / 430
stomach	100%	2171.17	359 / 359	100%	12.09	285 / 286
thymus	100%	2786.54	652 / 653	99%	7.40	600 / 605
kidney	100%	2781.80	89 / 89	98%	9.84	887 / 901
prostate	100%	2565.83	245 / 245	98%	6.37	494 / 502
brain	96%	1246.34	2541 / 2642	99%	7.89	701 / 705
adrenal gland	100%	3005.03	258 / 258	95%	6.60	219 / 230
skin	100%	3470.56	1807 / 1809	94%	8.81	443 / 472
pancreas	94%	1142.99	307 / 328	98%	9.45	175 / 178
liver	100%	1577.60	226 / 226	88%	4.22	359 / 406
adipose	100%	5252.49	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4784.72	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	11.23	29 / 29
spleen	100%	4084.30	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	10.09	45 / 45
ureter	0%	0	0 / 0	100%	2.32	1 / 1
peripheral blood	95%	2848.32	882 / 929	0%	0	0 / 0
heart	94%	1410.00	808 / 861	0%	0	0 / 0
muscle	91%	1018.90	731 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	69%	3.26	55 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000301	Biological process	negative regulation of synaptic vesicle exocytosis
GO_0008283	Biological process	cell population proliferation
GO_2000114	Biological process	regulation of establishment of cell polarity
GO_0099010	Biological process	modification of postsynaptic structure
GO_0017156	Biological process	calcium-ion regulated exocytosis
GO_1901888	Biological process	regulation of cell junction assembly
GO_0051649	Biological process	establishment of localization in cell
GO_0030033	Biological process	microvillus assembly
GO_0032486	Biological process	Rap protein signal transduction
GO_0045955	Biological process	negative regulation of calcium ion-dependent exocytosis
GO_0071320	Biological process	cellular response to cAMP
GO_0061028	Biological process	establishment of endothelial barrier
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0033625	Biological process	positive regulation of integrin activation
GO_0098978	Cellular component	glutamatergic synapse
GO_0005886	Cellular component	plasma membrane
GO_0005811	Cellular component	lipid droplet
GO_0045121	Cellular component	membrane raft
GO_0016020	Cellular component	membrane
GO_0035577	Cellular component	azurophil granule membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005911	Cellular component	cell-cell junction
GO_0005829	Cellular component	cytosol
GO_0019003	Molecular function	GDP binding
GO_0044877	Molecular function	protein-containing complex binding
GO_0003925	Molecular function	G protein activity
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	RAP1B
Protein name	small monomeric GTPase (EC 3.6.5.2) RAP1B, member of RAS oncogene family RAP1B, member of RAS oncogene family (cDNA, FLJ79442, highly similar to Ras-related protein Rap-1b) Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Synonyms	OK/SW-cl.11
Description	FUNCTION: GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. .
Accessions	ENST00000540209.5 [P61224-3] E7ESV4 ENST00000485252.6 ENST00000341355.9 [P61224-1] F5H491 F5GZG1 F5H6R7 ENST00000542018.5 F5H500 B7ZB78 ENST00000543393.5 ENST00000542145.5 [P61224-2] ENST00000450214.6 [P61224-4] ENST00000545720.6 ENST00000538283.5 ENST00000535492.5 ENST00000540781.5 ENST00000538980.5 F8WBC0 P61224 F5GX62 F5H077 ENST00000541386.5 ENST00000537460.5 [P61224-1] ENST00000534899.5 ENST00000378985.7 ENST00000539091.5 [P61224-4] F5H4H0 ENST00000543697.5 ENST00000545270.5 ENST00000489473.6 F5H7Y6 F5GYH7 ENST00000538877.5 F5GWU8 ENST00000393436.9 [P61224-1] F5H004 ENST00000425247.6 ENST00000453560.6 ENST00000541216.1 F5GYB5 ENST00000422358.6 F5H0B7 ENST00000250559.14 [P61224-1] F5H823 ENST00000541167.5 F5H0S2

RAP1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review