NTRK2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
astrocyte	23 studies	70% ± 21%	Explore
oligodendrocyte precursor cell	15 studies	66% ± 17%	Explore
smooth muscle cell	14 studies	31% ± 12%	Explore
oligodendrocyte	13 studies	33% ± 15%	Explore
glutamatergic neuron	12 studies	73% ± 22%	Explore
GABAergic neuron	11 studies	69% ± 24%	Explore
adipocyte	9 studies	32% ± 16%	Explore
pericyte	8 studies	46% ± 13%	Explore
endothelial cell	7 studies	43% ± 18%	Explore
interneuron	6 studies	71% ± 22%	Explore
microglial cell	6 studies	32% ± 17%	Explore
amacrine cell	6 studies	36% ± 26%	Explore
retina horizontal cell	6 studies	67% ± 16%	Explore
connective tissue cell	5 studies	34% ± 10%	Explore
neuron	5 studies	48% ± 13%	Explore
kidney loop of Henle epithelial cell	5 studies	26% ± 4%	Explore
Mueller cell	5 studies	40% ± 15%	Explore
fibroblast	4 studies	36% ± 19%	Explore
granule cell	4 studies	59% ± 6%	Explore
retinal ganglion cell	4 studies	26% ± 13%	Explore
basal cell	4 studies	40% ± 18%	Explore
macrophage	3 studies	37% ± 17%	Explore
progenitor cell	3 studies	27% ± 5%	Explore
GABAergic interneuron	3 studies	77% ± 16%	Explore
GABAergic amacrine cell	3 studies	43% ± 12%	Explore
glycinergic amacrine cell	3 studies	46% ± 14%	Explore
ependymal cell	3 studies	79% ± 8%	Explore
myoepithelial cell	3 studies	46% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	54% ± 22%	Explore
eye	3 studies	18% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	39350.34	2628 / 2642	99%	286.93	698 / 705
thymus	100%	17593.75	651 / 653	84%	80.80	509 / 605
breast	93%	8317.99	426 / 459	25%	10.57	283 / 1118
adipose	85%	9097.25	1022 / 1204	0%	0	0 / 0
blood vessel	75%	10629.77	997 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	60%	29.82	27 / 45
lung	14%	804.41	82 / 578	30%	28.77	342 / 1155
kidney	24%	1091.02	21 / 89	15%	3.33	138 / 901
esophagus	6%	284.42	87 / 1445	32%	29.15	59 / 183
pancreas	24%	913.31	78 / 328	13%	1.99	23 / 178
skin	30%	1462.77	542 / 1809	4%	1.23	19 / 472
heart	34%	1648.65	292 / 861	0%	0	0 / 0
ovary	32%	1610.67	58 / 180	2%	0.27	7 / 430
uterus	15%	768.05	26 / 170	17%	7.72	77 / 459
bladder	19%	617.86	4 / 21	6%	3.22	31 / 504
prostate	9%	455.13	22 / 245	1%	0.09	3 / 502
intestine	2%	78.97	18 / 966	6%	1.40	33 / 527
eye	0%	0	0 / 0	8%	2.91	6 / 80
spleen	7%	283.83	17 / 241	0%	0	0 / 0
adrenal gland	1%	46.16	2 / 258	5%	1.34	11 / 230
stomach	2%	76.97	7 / 359	2%	0.52	5 / 286
lymph node	0%	0	0 / 0	3%	1.66	1 / 29
muscle	2%	99.87	20 / 803	0%	0	0 / 0
peripheral blood	2%	86.39	19 / 929	0%	0	0 / 0
liver	0%	0	0 / 226	1%	0.30	4 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0031547	Biological process	brain-derived neurotrophic factor receptor signaling pathway
GO_0050772	Biological process	positive regulation of axonogenesis
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0007612	Biological process	learning
GO_1990416	Biological process	cellular response to brain-derived neurotrophic factor stimulus
GO_0046548	Biological process	retinal rod cell development
GO_0007631	Biological process	feeding behavior
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_1902430	Biological process	negative regulation of amyloid-beta formation
GO_0010628	Biological process	positive regulation of gene expression
GO_0007275	Biological process	multicellular organism development
GO_0001570	Biological process	vasculogenesis
GO_0001764	Biological process	neuron migration
GO_2000811	Biological process	negative regulation of anoikis
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0060291	Biological process	long-term synaptic potentiation
GO_0007623	Biological process	circadian rhythm
GO_0022011	Biological process	myelination in peripheral nervous system
GO_0033674	Biological process	positive regulation of kinase activity
GO_0030182	Biological process	neuron differentiation
GO_0042490	Biological process	mechanoreceptor differentiation
GO_0043087	Biological process	regulation of GTPase activity
GO_0099551	Biological process	trans-synaptic signaling by neuropeptide, modulating synaptic transmission
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0021954	Biological process	central nervous system neuron development
GO_0048709	Biological process	oligodendrocyte differentiation
GO_0099183	Biological process	trans-synaptic signaling by BDNF, modulating synaptic transmission
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0038179	Biological process	neurotrophin signaling pathway
GO_0021987	Biological process	cerebral cortex development
GO_0046777	Biological process	protein autophosphorylation
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0051965	Biological process	positive regulation of synapse assembly
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0019227	Biological process	neuronal action potential propagation
GO_0014047	Biological process	glutamate secretion
GO_0048935	Biological process	peripheral nervous system neuron development
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0043197	Cellular component	dendritic spine
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005769	Cellular component	early endosome
GO_0031901	Cellular component	early endosome membrane
GO_0043195	Cellular component	terminal bouton
GO_0043679	Cellular component	axon terminus
GO_0030425	Cellular component	dendrite
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0030424	Cellular component	axon
GO_0042803	Molecular function	protein homodimerization activity
GO_0060175	Molecular function	brain-derived neurotrophic factor receptor activity
GO_0048403	Molecular function	brain-derived neurotrophic factor binding
GO_0002020	Molecular function	protease binding
GO_0043121	Molecular function	neurotrophin binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NTRK2
Protein name	BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B) Neurotrophin receptor tyrosine kinase type 2 Neurotrophin receptor tyrosine kinase type 2 truncated isoform Neurotrophic receptor tyrosine kinase 2 Neurotrophic tyrosine kinase, receptor, type 2, isoform CRA_a (cDNA FLJ76753, highly similar to Homo sapiens neurotrophic tyrosine kinase, receptor, type 2 (NTRK2), transcript variant b, mRNA) Tyrosine-protein kinase receptor (EC 2.7.10.1)
Synonyms	TRKB hCG_1985371
Description	FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 . Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation . Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. .
Accessions	ENST00000692804.1 ENST00000686322.1 [Q16620-7] A0A8J8YUT9 ENST00000692389.1 [Q16620-2] ENST00000395882.6 [Q16620-2] A0A8I5KYI3 Q8WXJ4 A0A8I5KZB7 ENST00000689685.1 [Q16620-2] A0A8I5KPC6 Q5VWE5 A0A8I5KUH9 Q548C2 ENST00000693127.1 ENST00000304053.11 [Q16620-3] ENST00000692506.1 [Q16620-2] Q16620 ENST00000686259.1 [Q16620-1] ENST00000691788.1 [Q16620-1] A0A8I5KUZ1 ENST00000687148.1 [Q16620-2] ENST00000687386.1 ENST00000689301.1 A0A8I5KVH8 ENST00000693539.1 [Q16620-5] Q8WXJ8 ENST00000376208.6 [Q16620-3] ENST00000687596.1 [Q16620-2] ENST00000685387.1 ENST00000689815.1 [Q16620-2] ENST00000692181.1 [Q16620-1] ENST00000693109.1 [Q16620-2] ENST00000359847.4 [Q16620-2] ENST00000687636.1 [Q16620-5] ENST00000690281.1 [Q16620-2] ENST00000688013.1 [Q16620-2] ENST00000692473.1 ENST00000686324.1 [Q16620-4] ENST00000685720.1 [Q16620-5] ENST00000690163.1 ENST00000693384.1 ENST00000376213.6 [Q16620-1] ENST00000323115.11 A0A8I5KR47 A0A8I5KUV8 A0A8I5QKP8 ENST00000692762.1 [Q16620-2] ENST00000686542.1 ENST00000686496.1 [Q16620-1] ENST00000277120.8 [Q16620-4] ENST00000691415.1 [Q16620-2] ENST00000686443.1 [Q16620-3]

NTRK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review