HTR2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014059Biological processregulation of dopamine secretion
GO_0044380Biological processprotein localization to cytoskeleton
GO_0006096Biological processglycolytic process
GO_0031652Biological processpositive regulation of heat generation
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0045907Biological processpositive regulation of vasoconstriction
GO_0050966Biological processdetection of mechanical stimulus involved in sensory perception of pain
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0007210Biological processserotonin receptor signaling pathway
GO_0051209Biological processrelease of sequestered calcium ion into cytosol
GO_0098664Biological processG protein-coupled serotonin receptor signaling pathway
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0010513Biological processpositive regulation of phosphatidylinositol biosynthetic process
GO_0046718Biological processsymbiont entry into host cell
GO_0014832Biological processurinary bladder smooth muscle contraction
GO_0007208Biological processphospholipase C-activating serotonin receptor signaling pathway
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_0007268Biological processchemical synaptic transmission
GO_2000573Biological processpositive regulation of DNA biosynthetic process
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0043267Biological processnegative regulation of potassium ion transport
GO_1901731Biological processpositive regulation of platelet aggregation
GO_0014824Biological processartery smooth muscle contraction
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0007613Biological processmemory
GO_0001659Biological processtemperature homeostasis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0050729Biological processpositive regulation of inflammatory response
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0048148Biological processbehavioral response to cocaine
GO_0046960Biological processsensitization
GO_0045821Biological processpositive regulation of glycolytic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0051967Biological processnegative regulation of synaptic transmission, glutamatergic
GO_0098978Cellular componentglutamatergic synapse
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0043198Cellular componentdendritic shaft
GO_0005883Cellular componentneurofilament
GO_0070852Cellular componentcell body fiber
GO_0043025Cellular componentneuronal cell body
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0045211Cellular componentpostsynaptic membrane
GO_0098666Cellular componentG protein-coupled serotonin receptor complex
GO_0030424Cellular componentaxon
GO_0005901Cellular componentcaveola
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0001618Molecular functionvirus receptor activity
GO_0030296Molecular functionprotein tyrosine kinase activator activity
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0051378Molecular functionserotonin binding
GO_0071886Molecular function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0001587Molecular functionGq/11-coupled serotonin receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHTR2A
Protein name5-hydroxytryptamine receptor 2A (Serotonin receptor 2A)
5-hydroxytryptamine (Serotonin) receptor 2A
5-hydroxytryptamine receptor 2A (5-HT-2) (Serotonin receptor 2A)
5-hydroxytryptamine receptor 2A (5-HT-2) (5-HT-2A) (Serotonin receptor 2A)
SynonymsHTR2
DescriptionFUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors . Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways . Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores . Affects neural activity, perception, cognition and mood . Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. .; FUNCTION: (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. .

FUNCTION: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). .

AccessionsL7QJB5
B3VRC0
ENST00000543956.5
A0A7P0PKG8
A0A087WZJ9
ENST00000542664.4 [P28223-1]
ENST00000612998.1
B3VRB0
P28223
B3VRB5
Q9P2Q9