ABL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0038189Biological processneuropilin signaling pathway
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0030516Biological processregulation of axon extension
GO_0045580Biological processregulation of T cell differentiation
GO_0000278Biological processmitotic cell cycle
GO_0001922Biological processB-1 B cell homeostasis
GO_0030041Biological processactin filament polymerization
GO_0032489Biological processregulation of Cdc42 protein signal transduction
GO_0050885Biological processneuromuscular process controlling balance
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_1905555Biological processpositive regulation of blood vessel branching
GO_0030509Biological processBMP signaling pathway
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0051402Biological processneuron apoptotic process
GO_0030036Biological processactin cytoskeleton organization
GO_1902036Biological processregulation of hematopoietic stem cell differentiation
GO_2000145Biological processregulation of cell motility
GO_0050798Biological processactivated T cell proliferation
GO_0030035Biological processmicrospike assembly
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_1900272Biological processnegative regulation of long-term synaptic potentiation
GO_0006914Biological processautophagy
GO_0006468Biological processprotein phosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_1904531Biological processpositive regulation of actin filament binding
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0006979Biological processresponse to oxidative stress
GO_0051726Biological processregulation of cell cycle
GO_0070301Biological processcellular response to hydrogen peroxide
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_1903351Biological processcellular response to dopamine
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_1903210Biological processpodocyte apoptotic process
GO_1905244Biological processregulation of modification of synaptic structure
GO_1903905Biological processpositive regulation of establishment of T cell polarity
GO_0050852Biological processT cell receptor signaling pathway
GO_0002322Biological processB cell proliferation involved in immune response
GO_1904528Biological processpositive regulation of microtubule binding
GO_0090050Biological processpositive regulation of cell migration involved in sprouting angiogenesis
GO_0030182Biological processneuron differentiation
GO_1903055Biological processpositive regulation of extracellular matrix organization
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0070371Biological processERK1 and ERK2 cascade
GO_0010506Biological processregulation of autophagy
GO_0051450Biological processmyoblast proliferation
GO_0043542Biological processendothelial cell migration
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_1900006Biological processpositive regulation of dendrite development
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_0006355Biological processregulation of DNA-templated transcription
GO_0001843Biological processneural tube closure
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0045930Biological processnegative regulation of mitotic cell cycle
GO_0046632Biological processalpha-beta T cell differentiation
GO_2000406Biological processpositive regulation of T cell migration
GO_0046777Biological processprotein autophosphorylation
GO_1904157Biological processDN4 thymocyte differentiation
GO_0042770Biological processsignal transduction in response to DNA damage
GO_1990051Biological processactivation of protein kinase C activity
GO_0022408Biological processnegative regulation of cell-cell adhesion
GO_0033690Biological processpositive regulation of osteoblast proliferation
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0050853Biological processB cell receptor signaling pathway
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_0045907Biological processpositive regulation of vasoconstriction
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0051353Biological processpositive regulation of oxidoreductase activity
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0035791Biological processplatelet-derived growth factor receptor-beta signaling pathway
GO_0038083Biological processpeptidyl-tyrosine autophosphorylation
GO_0060038Biological processcardiac muscle cell proliferation
GO_0071103Biological processDNA conformation change
GO_0034599Biological processcellular response to oxidative stress
GO_0002333Biological processtransitional one stage B cell differentiation
GO_0007204Biological processpositive regulation of cytosolic calcium ion concentration
GO_2000096Biological processpositive regulation of Wnt signaling pathway, planar cell polarity pathway
GO_0048538Biological processthymus development
GO_0051894Biological processpositive regulation of focal adhesion assembly
GO_0021587Biological processcerebellum morphogenesis
GO_0030100Biological processregulation of endocytosis
GO_0051281Biological processpositive regulation of release of sequestered calcium ion into cytosol
GO_0051444Biological processnegative regulation of ubiquitin-protein transferase activity
GO_0043065Biological processpositive regulation of apoptotic process
GO_0031113Biological processregulation of microtubule polymerization
GO_2000042Biological processnegative regulation of double-strand break repair via homologous recombination
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0060020Biological processBergmann glial cell differentiation
GO_1904518Biological processprotein localization to cytoplasmic microtubule plus-end
GO_0009791Biological processpost-embryonic development
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0006974Biological processDNA damage response
GO_0008306Biological processassociative learning
GO_0051649Biological processestablishment of localization in cell
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0048536Biological processspleen development
GO_0071871Biological processresponse to epinephrine
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0060563Biological processneuroepithelial cell differentiation
GO_0036211Biological processprotein modification process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0051882Biological processmitochondrial depolarization
GO_0090398Biological processcellular senescence
GO_0032729Biological processpositive regulation of type II interferon production
GO_0006298Biological processmismatch repair
GO_0030155Biological processregulation of cell adhesion
GO_0098609Biological processcell-cell adhesion
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_2000773Biological processnegative regulation of cellular senescence
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0098794Cellular componentpostsynapse
GO_0043025Cellular componentneuronal cell body
GO_0005634Cellular componentnucleus
GO_0001726Cellular componentruffle
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0015629Cellular componentactin cytoskeleton
GO_0016604Cellular componentnuclear body
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0032991Cellular componentprotein-containing complex
GO_0005737Cellular componentcytoplasm
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005829Cellular componentcytosol
GO_0030426Cellular componentgrowth cone
GO_0031965Cellular componentnuclear membrane
GO_0003785Molecular functionactin monomer binding
GO_0046875Molecular functionephrin receptor binding
GO_0000405Molecular functionbubble DNA binding
GO_0004672Molecular functionprotein kinase activity
GO_0030145Molecular functionmanganese ion binding
GO_0042169Molecular functionSH2 domain binding
GO_0005524Molecular functionATP binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0038191Molecular functionneuropilin binding
GO_0005080Molecular functionprotein kinase C binding
GO_0097100Molecular functionsupercoiled DNA binding
GO_0019905Molecular functionsyntaxin binding
GO_0017124Molecular functionSH3 domain binding
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0051015Molecular functionactin filament binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005515Molecular functionprotein binding
GO_0070097Molecular functiondelta-catenin binding
GO_0003677Molecular functionDNA binding
GO_0004515Molecular functionnicotinate-nucleotide adenylyltransferase activity
GO_0070064Molecular functionproline-rich region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000400Molecular functionfour-way junction DNA binding
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0016301Molecular functionkinase activity
GO_0003713Molecular functiontranscription coactivator activity

IV. Literature review

[source]
Gene nameABL1
Protein nameC-abl
ABL proto-oncogene 1, non-receptor tyrosine kinase
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
ABL1 protein
SynonymsABL
JTK7
DescriptionFUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9 . Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' . ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner (By similarity). Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1 (By similarity). Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). .

AccessionsQ13914
Q13915
ENST00000318560.6 [P00519-1]
Q13689
Q3B837
ENST00000372348.9 [P00519-2]
Q13691
R4GRW0
ENST00000393293.4
P00519
Q86Y36
Q13688
Q3B836