FGFR4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGFR4 at tissue level.

III. Associated gene sets

GO_0055062Biological processphosphate ion homeostasis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0045862Biological processpositive regulation of proteolysis
GO_0010628Biological processpositive regulation of gene expression
GO_0007275Biological processmulticellular organism development
GO_0019216Biological processregulation of lipid metabolic process
GO_0010715Biological processregulation of extracellular matrix disassembly
GO_0043085Biological processpositive regulation of catalytic activity
GO_0033674Biological processpositive regulation of kinase activity
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_2000573Biological processpositive regulation of DNA biosynthetic process
GO_0070857Biological processregulation of bile acid biosynthetic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_1903412Biological processresponse to bile acid
GO_0046777Biological processprotein autophosphorylation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0016477Biological processcell migration
GO_0042593Biological processglucose homeostasis
GO_0042632Biological processcholesterol homeostasis
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0043235Cellular componentreceptor complex
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005911Cellular componentcell-cell junction
GO_0005783Cellular componentendoplasmic reticulum
GO_0030133Cellular componenttransport vesicle
GO_0005768Cellular componentendosome
GO_0008201Molecular functionheparin binding
GO_0005007Molecular functionfibroblast growth factor receptor activity
GO_0005524Molecular functionATP binding
GO_0017134Molecular functionfibroblast growth factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGFR4
Protein nameFibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Fibroblast growth factor receptor 4 (Soluble FGFR4 variant 1)
Soluble FGFR4 variant 2
Fibroblast growth factor receptor 4
Fibroblast growth factor receptor (EC 2.7.10.1)
SynonymsTKF
JTK2
DescriptionFUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. .

AccessionsENST00000511076.1
P22455
ENST00000514472.1
ENST00000393648.6
ENST00000430285.5
H0Y9P2
ENST00000503708.5
ENST00000502906.5 [P22455-1]
B5A965
ENST00000513166.1
D6RG06
ENST00000510911.5
E7EWF4
D6R9V0
ENST00000393637.5 [P22455-2]
J3KPQ0
ENST00000292408.9 [P22455-1]
D6RJD4
B5A964