Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 8 studies | 27% ± 19% | |
| endothelial cell | 6 studies | 31% ± 9% | |
| GABAergic neuron | 4 studies | 31% ± 8% | |
| glutamatergic neuron | 4 studies | 37% ± 6% | |
| hepatocyte | 3 studies | 42% ± 14% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 27% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2838.96 | 226 / 226 | 98% | 35.28 | 397 / 406 |
| brain | 98% | 437.66 | 2600 / 2642 | 91% | 2.99 | 640 / 705 |
| ovary | 67% | 151.80 | 120 / 180 | 0% | 0.01 | 1 / 430 |
| intestine | 37% | 296.61 | 353 / 966 | 8% | 0.22 | 42 / 527 |
| adrenal gland | 13% | 13.50 | 33 / 258 | 22% | 3.32 | 50 / 230 |
| pancreas | 6% | 6.68 | 20 / 328 | 12% | 0.33 | 22 / 178 |
| stomach | 0% | 0 | 0 / 359 | 12% | 0.24 | 34 / 286 |
| esophagus | 0% | 0.15 | 2 / 1445 | 11% | 0.53 | 20 / 183 |
| skin | 4% | 3.78 | 69 / 1809 | 7% | 0.17 | 31 / 472 |
| uterus | 0% | 0 | 0 / 170 | 7% | 0.17 | 34 / 459 |
| prostate | 3% | 2.15 | 8 / 245 | 2% | 0.03 | 12 / 502 |
| lung | 0% | 0 | 0 / 578 | 6% | 0.23 | 65 / 1155 |
| bladder | 0% | 0 | 0 / 21 | 5% | 0.10 | 24 / 504 |
| kidney | 0% | 0 | 0 / 89 | 5% | 0.27 | 42 / 901 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.04 | 1 / 45 |
| breast | 0% | 1.19 | 2 / 459 | 1% | 0.01 | 8 / 1118 |
| thymus | 0% | 0.24 | 2 / 653 | 0% | 0.03 | 3 / 605 |
| heart | 1% | 0.44 | 6 / 861 | 0% | 0 | 0 / 0 |
| spleen | 0% | 3.54 | 1 / 241 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0.38 | 3 / 1204 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071577 | Biological process | zinc ion transmembrane transport |
| GO_0062111 | Biological process | zinc ion import into organelle |
| GO_0030026 | Biological process | intracellular manganese ion homeostasis |
| GO_0006882 | Biological process | intracellular zinc ion homeostasis |
| GO_0010312 | Biological process | detoxification of zinc ion |
| GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
| GO_0140048 | Biological process | manganese ion export across plasma membrane |
| GO_0006878 | Biological process | intracellular copper ion homeostasis |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0006828 | Biological process | manganese ion transport |
| GO_1904385 | Biological process | cellular response to angiotensin |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0055038 | Cellular component | recycling endosome membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0008021 | Cellular component | synaptic vesicle |
| GO_0005385 | Molecular function | zinc ion transmembrane transporter activity |
| GO_0140983 | Molecular function | calcium:manganese antiporter activity |
| GO_0005384 | Molecular function | manganese ion transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SLC30A10 |
| Protein name | Solute carrier family 30, member 10, isoform CRA_a (cDNA FLJ33487 fis, clone BRAMY2003538, highly similar to Homo sapiens solute carrier family 30, member 10 (SLC30A10), transcript variant 1, mRNA) SLC30A10 protein Calcium/manganese antiporter SLC30A10 (Solute carrier family 30 member 10) (Zinc transporter 10) (ZnT-10) Solute carrier family 30 member 10 |
| Synonyms | hCG_25737 ZNT8 ZNT10 |
| Description | FUNCTION: Calcium:manganese antiporter of the plasma membrane mediating the efflux of intracellular manganese coupled to an active extracellular calcium exchange . Required for intracellular manganese homeostasis, an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. Manganese can also be cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis . Could also have an intracellular zinc ion transporter activity, directly regulating intracellular zinc ion homeostasis and more indirectly various signaling pathway and biological processes . . |
| Accessions | A0A8Q3WLF3 ENST00000366926.4 [Q6XR72-4] ENST00000356609.2 [Q6XR72-3] Q1RMY7 Q6XR72 ENST00000696608.1 B3KR19 |
