DDR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	17 studies	37% ± 13%	Explore
basal cell	12 studies	33% ± 13%	Explore
astrocyte	10 studies	28% ± 8%	Explore
type I pneumocyte	9 studies	23% ± 8%	Explore
epithelial cell	9 studies	32% ± 16%	Explore
oligodendrocyte	7 studies	26% ± 6%	Explore
club cell	5 studies	27% ± 10%	Explore
respiratory goblet cell	5 studies	25% ± 8%	Explore
secretory cell	5 studies	30% ± 11%	Explore
goblet cell	5 studies	25% ± 4%	Explore
oligodendrocyte precursor cell	4 studies	39% ± 13%	Explore
ionocyte	3 studies	34% ± 6%	Explore
squamous epithelial cell	3 studies	41% ± 25%	Explore
pancreatic A cell	3 studies	49% ± 23%	Explore
type B pancreatic cell	3 studies	51% ± 22%	Explore
Mueller cell	3 studies	33% ± 5%	Explore
abnormal cell	3 studies	30% ± 17%	Explore
pancreatic ductal cell	3 studies	53% ± 26%	Explore
enteroendocrine cell	3 studies	23% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	18% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	5 studies	21% ± 4%	Explore
lung	3 studies	37% ± 3%	Explore
pancreas	3 studies	48% ± 19%	Explore
intestine	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	11738.07	2634 / 2642	99%	419.38	701 / 705
ovary	100%	6848.97	180 / 180	99%	156.13	425 / 430
thymus	100%	16202.01	653 / 653	98%	177.63	595 / 605
pancreas	100%	9704.45	328 / 328	97%	127.91	173 / 178
prostate	100%	12776.69	245 / 245	97%	103.64	486 / 502
lung	97%	6044.47	558 / 578	97%	151.78	1120 / 1155
intestine	95%	7137.49	921 / 966	97%	124.59	513 / 527
stomach	98%	9053.26	352 / 359	94%	107.83	269 / 286
kidney	100%	14417.34	89 / 89	90%	103.98	807 / 901
esophagus	90%	9967.52	1303 / 1445	99%	167.37	181 / 183
uterus	98%	5064.75	167 / 170	91%	141.52	416 / 459
breast	84%	10284.79	385 / 459	98%	163.94	1099 / 1118
bladder	86%	7403.14	18 / 21	95%	131.52	479 / 504
adrenal gland	98%	8407.82	253 / 258	60%	41.22	139 / 230
skin	75%	13551.99	1353 / 1809	76%	61.66	361 / 472
tonsil	0%	0	0 / 0	100%	178.90	45 / 45
ureter	0%	0	0 / 0	100%	59.28	1 / 1
muscle	81%	3771.61	652 / 803	0%	0	0 / 0
blood vessel	74%	2349.95	982 / 1335	0%	0	0 / 0
adipose	67%	3583.25	806 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	65%	42.94	52 / 80
heart	63%	3107.71	541 / 861	0%	0	0 / 0
spleen	44%	1158.73	106 / 241	0%	0	0 / 0
liver	2%	52.67	5 / 226	17%	20.75	71 / 406
peripheral blood	9%	322.01	85 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	1.11	1 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0061302	Biological process	smooth muscle cell-matrix adhesion
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0014909	Biological process	smooth muscle cell migration
GO_0061564	Biological process	axon development
GO_0008283	Biological process	cell population proliferation
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0001558	Biological process	regulation of cell growth
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0060444	Biological process	branching involved in mammary gland duct morphogenesis
GO_0007275	Biological process	multicellular organism development
GO_0038063	Biological process	collagen-activated tyrosine kinase receptor signaling pathway
GO_0007155	Biological process	cell adhesion
GO_0060749	Biological process	mammary gland alveolus development
GO_0001952	Biological process	regulation of cell-matrix adhesion
GO_0010715	Biological process	regulation of extracellular matrix disassembly
GO_0038083	Biological process	peptidyl-tyrosine autophosphorylation
GO_0033674	Biological process	positive regulation of kinase activity
GO_0044319	Biological process	wound healing, spreading of cells
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1990138	Biological process	neuron projection extension
GO_0007595	Biological process	lactation
GO_0043583	Biological process	ear development
GO_0046777	Biological process	protein autophosphorylation
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0007566	Biological process	embryo implantation
GO_0005615	Cellular component	extracellular space
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0004714	Molecular function	transmembrane receptor protein tyrosine kinase activity
GO_0038062	Molecular function	protein tyrosine kinase collagen receptor activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0005518	Molecular function	collagen binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	DDR1
Protein name	Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a) receptor protein-tyrosine kinase (EC 2.7.10.1) Discoidin domain receptor tyrosine kinase 1 Discoidin domain receptor DDR1e Discoidin domain receptor tyrosine kinase 1 (Epithelial discoidin domain-containing receptor 1) Discoidin domain receptor DDR1d Epithelial discoidin domain-containing receptor 1
Synonyms	EDDR1 PTK3A NTRK4 RTK6 TRKE CAK NEP
Description	FUNCTION: Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. .
Accessions	ENST00000419412.5 [Q08345-2] E7ES06 ENST00000453391.5 ENST00000450117.5 ENST00000460944.6 ENST00000428153.6 D6R9C4 E7ETX3 ENST00000400492.5 [Q08345-1] ENST00000454377.5 E7EVT1 E7EVW6 ENST00000452052.5 Q96T62 ENST00000482873.6 [Q08345-4] ENST00000454774.5 [Q08345-2] ENST00000620318.4 [Q08345-4] ENST00000513043.5 ENST00000448263.5 ENST00000553015.5 [Q08345-1] ENST00000430486.1 ENST00000503495.5 ENST00000376570.8 [Q08345-2] ENST00000421672.5 H0Y717 E7ERI6 ENST00000426303.5 A0A0G2JIA2 ENST00000437449.5 ENST00000448651.5 A0A0G2JI85 ENST00000515233.5 ENST00000434428.5 D6RGW5 ENST00000417521.5 ENST00000504679.5 ENST00000515881.5 ENST00000548962.5 [Q08345-6] ENST00000484556.1 ENST00000514434.1 ENST00000376567.6 [Q08345-2] A0A0G2JHK4 ENST00000454612.6 [Q08345-2] ENST00000400489.7 [Q08345-2] ENST00000396342.6 ENST00000400484.5 ENST00000508317.5 E7EUD5 ENST00000618059.2 [Q08345-4] ENST00000445749.5 D6RAJ3 ENST00000442268.5 ENST00000512694.5 ENST00000511510.5 ENST00000621544.4 [Q08345-4] ENST00000513240.5 [Q08345-5] Q08345 ENST00000439604.1 ENST00000419285.5 E7ERN0 ENST00000512725.5 E7EQ23 ENST00000617572.3 [Q08345-4] ENST00000503180.5 ENST00000429699.5 [Q08345-1] ENST00000508312.5 [Q08345-6] ENST00000550384.5 [Q08345-6] ENST00000418800.6 [Q08345-2] ENST00000434134.5 ENST00000550666.3 D6RBU7 ENST00000418397.5 A0A0G2JIZ7 ENST00000400411.5 [Q08345-2] ENST00000451632.5 Q96T61 ENST00000259875.11 [Q08345-2] ENST00000415092.5 [Q08345-2] ENST00000453510.5 [Q08345-2] ENST00000434782.5 ENST00000503628.5 E7EX99 ENST00000548693.4 ENST00000429955.5 ENST00000552434.5 ENST00000420929.5 ENST00000421124.6 ENST00000400407.5 ENST00000504927.5 ENST00000504651.5 ENST00000505066.5 E7ENJ2 A0A0G2JJA0 ENST00000445017.5 D6RB82 ENST00000422275.5 ENST00000413044.5 ENST00000413115.5 H0Y9F4 ENST00000376568.8 [Q08345-1] ENST00000446312.5 E7EUP7 ENST00000503670.5 E7EQ30 A0A140T9T5 ENST00000502955.5 ENST00000507046.5 ENST00000505534.5 ENST00000433393.5 A0A140T972 ENST00000422628.5 E7EPN2 E7ETI3 ENST00000383377.6 [Q08345-1] ENST00000433322.5 ENST00000444198.5 ENST00000507901.5 ENST00000400491.5 [Q08345-1] ENST00000412329.5 [Q08345-1] ENST00000421499.5 ENST00000444160.5 ENST00000439772.5 ENST00000376575.7 [Q08345-4] E7EN94 ENST00000512336.5 ENST00000414077.5 ENST00000452093.5 ENST00000552721.4 [Q08345-6] E7EPH4 D6RB35 A2ABM8 ENST00000424544.2 E7ESR9 A0A0G2JNZ7 ENST00000437124.6 ENST00000414378.5 ENST00000513749.5 ENST00000449518.5 [Q08345-1] H0YAH6 ENST00000400488.5 [Q08345-2] ENST00000440427.5 ENST00000548133.4 [Q08345-1] ENST00000412274.6 ENST00000452441.5 [Q08345-1] ENST00000416705.5 A2ABL2 ENST00000509639.5 A0A0A0MSX3 ENST00000433244.5 ENST00000324771.12 [Q08345-1] ENST00000416487.5 ENST00000414794.5 A2ABL0 ENST00000515219.5 ENST00000427053.6 [Q08345-2] ENST00000435818.5 ENST00000430933.5 [Q08345-1] ENST00000458576.5 E7EXB0 ENST00000438728.5 ENST00000376569.7 [Q08345-2] ENST00000552068.5 [Q08345-1] ENST00000400414.5 [Q08345-1] ENST00000421229.6 [Q08345-2] ENST00000550395.5 [Q08345-1] ENST00000549026.3 [Q08345-6] ENST00000431334.5 ENST00000616404.2 ENST00000400410.5 [Q08345-2] ENST00000400486.5 [Q08345-2] ENST00000446697.5 ENST00000448537.1

DDR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review