CARD9 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CARD9 at tissue level.

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0051260Biological processprotein homooligomerization
GO_0032722Biological processpositive regulation of chemokine production
GO_0061760Biological processantifungal innate immune response
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032495Biological processresponse to muramyl dipeptide
GO_0043330Biological processresponse to exogenous dsRNA
GO_0051607Biological processdefense response to virus
GO_0048874Biological processhost-mediated regulation of intestinal microbiota composition
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0032663Biological processregulation of interleukin-2 production
GO_0045089Biological processpositive regulation of innate immune response
GO_0032494Biological processresponse to peptidoglycan
GO_0051403Biological processstress-activated MAPK cascade
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0002446Biological processneutrophil mediated immunity
GO_0042981Biological processregulation of apoptotic process
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0032725Biological processpositive regulation of granulocyte macrophage colony-stimulating factor production
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0016064Biological processimmunoglobulin mediated immune response
GO_1904044Biological processresponse to aldosterone
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0001819Biological processpositive regulation of cytokine production
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0005886Cellular componentplasma membrane
GO_0032449Cellular componentCBM complex
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0050700Molecular functionCARD domain binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0035591Molecular functionsignaling adaptor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCARD9
Protein nameCaspase recruitment domain-containing protein 9 (hCARD9)
Synonyms
DescriptionFUNCTION: Adapter protein that plays a key role in innate immune response against fungi by forming signaling complexes downstream of C-type lectin receptors . CARD9-mediated signals are essential for antifungal immunity against a subset of fungi from the phylum Ascomycota . Transduces signals in myeloid cells downstream of C-type lectin receptors CLEC7A (dectin-1), CLEC6A (dectin-2) and CLEC4E (Mincle), which detect pathogen-associated molecular pattern metabolites (PAMPs), such as fungal carbohydrates, and trigger CARD9 activation (By similarity). Upon activation, CARD9 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines . CARD9 signaling in antigen-presenting cells links innate sensing of fungi to the activation of adaptive immunity and provides a cytokine milieu that induces the development and subsequent of interleukin 17-producing T helper (Th17) cells . Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). CARD9 can also be engaged independently of BCL10: forms a complex with RASGRF1 downstream of C-type lectin receptors, which recruits and activates HRAS, leading to ERK activation and the production of cytokines (By similarity). Acts as an important regulator of the intestinal commensal fungi (mycobiota) component of the gut microbiota . Plays an essential role in antifungal immunity against dissemination of gut fungi: acts by promoting induction of antifungal IgG antibodies response in CX3CR1(+) macrophages to confer protection against disseminated C.albicans or C.auris infection . Also mediates immunity against other pathogens, such as certain bacteria, viruses and parasites; CARD9 signaling is however redundant with other innate immune responses (By similarity). In response to L.monocytogenes infection, required for the production of inflammatory cytokines activated by intracellular peptidoglycan: acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B (By similarity). .

AccessionsENST00000371734.7 [Q9H257-2]
ENST00000489932.2 [Q9H257-3]
ENST00000371732.10 [Q9H257-1]
Q9H257