MAP2K7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043507Biological processpositive regulation of JUN kinase activity
GO_0007254Biological processJNK cascade
GO_0009408Biological processresponse to heat
GO_2000671Biological processregulation of motor neuron apoptotic process
GO_1904355Biological processpositive regulation of telomere capping
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007165Biological processsignal transduction
GO_0009411Biological processresponse to UV
GO_0038095Biological processFc-epsilon receptor signaling pathway
GO_0071347Biological processcellular response to interleukin-1
GO_0034612Biological processresponse to tumor necrosis factor
GO_0006970Biological processresponse to osmotic stress
GO_0051403Biological processstress-activated MAPK cascade
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0051973Biological processpositive regulation of telomerase activity
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0090398Biological processcellular senescence
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0009611Biological processresponse to wounding
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0004707Molecular functionMAP kinase activity
GO_0140677Molecular functionmolecular function activator activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0008545Molecular functionJUN kinase kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0004708Molecular functionMAP kinase kinase activity
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAP2K7
Protein nameDual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
SynonymsSKK4
MKK7
MEK7
PRKMK7
JNKK2
DescriptionFUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE . .

AccessionsO14733
ENST00000397979.4 [O14733-1]
ENST00000397983.7 [O14733-3]
ENST00000397981.7 [O14733-4]