GAS6 | OmnibusX

Name	Number of supported studies	Average coverage
pericyte	27 studies	39% ± 20%	Explore
endothelial cell	26 studies	32% ± 13%	Explore
fibroblast	21 studies	30% ± 9%	Explore
smooth muscle cell	19 studies	27% ± 11%	Explore
macrophage	18 studies	31% ± 16%	Explore
plasmacytoid dendritic cell	17 studies	44% ± 15%	Explore
endothelial cell of lymphatic vessel	16 studies	30% ± 10%	Explore
type I pneumocyte	11 studies	44% ± 17%	Explore
endothelial cell of artery	10 studies	32% ± 14%	Explore
capillary endothelial cell	9 studies	32% ± 13%	Explore
mesothelial cell	9 studies	42% ± 19%	Explore
microglial cell	9 studies	31% ± 9%	Explore
myofibroblast cell	8 studies	37% ± 13%	Explore
ciliated cell	8 studies	29% ± 10%	Explore
connective tissue cell	7 studies	25% ± 9%	Explore
amacrine cell	7 studies	29% ± 10%	Explore
vein endothelial cell	7 studies	28% ± 14%	Explore
endothelial cell of vascular tree	7 studies	30% ± 10%	Explore
plasma cell	6 studies	32% ± 10%	Explore
retina horizontal cell	6 studies	48% ± 12%	Explore
basal cell	6 studies	25% ± 6%	Explore
epithelial cell	5 studies	31% ± 6%	Explore
myeloid cell	5 studies	27% ± 9%	Explore
ionocyte	4 studies	27% ± 10%	Explore
conventional dendritic cell	4 studies	30% ± 8%	Explore
glomerular endothelial cell	4 studies	64% ± 1%	Explore
renal alpha-intercalated cell	4 studies	37% ± 13%	Explore
retinal ganglion cell	4 studies	58% ± 29%	Explore
cardiac muscle cell	4 studies	16% ± 1%	Explore
myoepithelial cell	4 studies	48% ± 15%	Explore
GABAergic neuron	4 studies	41% ± 13%	Explore
dendritic cell	4 studies	30% ± 15%	Explore
intestinal crypt stem cell	4 studies	26% ± 5%	Explore
IgG plasma cell	3 studies	24% ± 4%	Explore
muscle cell	3 studies	32% ± 13%	Explore
astrocyte	3 studies	21% ± 3%	Explore
glutamatergic neuron	3 studies	52% ± 9%	Explore
secretory cell	3 studies	66% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	6 studies	29% ± 11%	Explore
lung	4 studies	21% ± 6%	Explore
eye	3 studies	17% ± 2%	Explore
uterus	3 studies	29% ± 8%	Explore
intestine	3 studies	17% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	15407.81	652 / 653	100%	199.13	605 / 605
ovary	100%	15253.04	180 / 180	99%	133.62	425 / 430
prostate	100%	16475.49	245 / 245	98%	45.59	491 / 502
intestine	98%	8478.32	951 / 966	96%	62.09	504 / 527
stomach	99%	7706.72	356 / 359	94%	51.50	269 / 286
lung	99%	13506.06	575 / 578	92%	43.97	1063 / 1155
kidney	99%	9435.70	88 / 89	92%	56.06	833 / 901
esophagus	99%	16900.94	1433 / 1445	92%	39.63	168 / 183
breast	99%	10973.14	456 / 459	91%	47.65	1019 / 1118
uterus	100%	25090.75	170 / 170	88%	65.09	406 / 459
pancreas	84%	4301.75	274 / 328	96%	82.75	170 / 178
bladder	100%	19235.81	21 / 21	78%	48.67	392 / 504
adrenal gland	76%	3937.17	195 / 258	87%	64.31	199 / 230
skin	100%	27719.76	1808 / 1809	62%	19.96	292 / 472
brain	65%	2827.81	1721 / 2642	93%	25.83	653 / 705
liver	60%	2792.50	135 / 226	68%	23.45	278 / 406
blood vessel	100%	49904.95	1334 / 1335	0%	0	0 / 0
heart	100%	13591.13	859 / 861	0%	0	0 / 0
adipose	100%	14735.99	1198 / 1204	0%	0	0 / 0
muscle	97%	7236.76	776 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	39.98	40 / 45
spleen	83%	4287.92	199 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	73%	20.74	58 / 80
lymph node	0%	0	0 / 0	45%	8.70	13 / 29
peripheral blood	1%	19.78	5 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1900142	Biological process	negative regulation of oligodendrocyte apoptotic process
GO_0031589	Biological process	cell-substrate adhesion
GO_0071333	Biological process	cellular response to glucose stimulus
GO_0050766	Biological process	positive regulation of phagocytosis
GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_0071466	Biological process	cellular response to xenobiotic stimulus
GO_0035457	Biological process	cellular response to interferon-alpha
GO_0072659	Biological process	protein localization to plasma membrane
GO_0071307	Biological process	cellular response to vitamin K
GO_0032148	Biological process	activation of protein kinase B activity
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_2000270	Biological process	negative regulation of fibroblast apoptotic process
GO_0032692	Biological process	negative regulation of interleukin-1 production
GO_0033028	Biological process	myeloid cell apoptotic process
GO_0085029	Biological process	extracellular matrix assembly
GO_0032715	Biological process	negative regulation of interleukin-6 production
GO_0003104	Biological process	positive regulation of glomerular filtration
GO_0007165	Biological process	signal transduction
GO_0007167	Biological process	enzyme-linked receptor protein signaling pathway
GO_0010628	Biological process	positive regulation of gene expression
GO_0001961	Biological process	positive regulation of cytokine-mediated signaling pathway
GO_0046827	Biological process	positive regulation of protein export from nucleus
GO_0001764	Biological process	neuron migration
GO_0031100	Biological process	animal organ regeneration
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0007596	Biological process	blood coagulation
GO_0097028	Biological process	dendritic cell differentiation
GO_0009267	Biological process	cellular response to starvation
GO_0071363	Biological process	cellular response to growth factor stimulus
GO_0033033	Biological process	negative regulation of myeloid cell apoptotic process
GO_0035754	Biological process	B cell chemotaxis
GO_0045860	Biological process	positive regulation of protein kinase activity
GO_0046813	Biological process	receptor-mediated virion attachment to host cell
GO_0070168	Biological process	negative regulation of biomineral tissue development
GO_2000510	Biological process	positive regulation of dendritic cell chemotaxis
GO_0046718	Biological process	symbiont entry into host cell
GO_0043277	Biological process	apoptotic cell clearance
GO_0032825	Biological process	positive regulation of natural killer cell differentiation
GO_0019064	Biological process	fusion of virus membrane with host plasma membrane
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0097241	Biological process	hematopoietic stem cell migration to bone marrow
GO_0006909	Biological process	phagocytosis
GO_0032689	Biological process	negative regulation of type II interferon production
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006468	Biological process	protein phosphorylation
GO_0032720	Biological process	negative regulation of tumor necrosis factor production
GO_0044346	Biological process	fibroblast apoptotic process
GO_0010804	Biological process	negative regulation of tumor necrosis factor-mediated signaling pathway
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0019079	Biological process	viral genome replication
GO_2000669	Biological process	negative regulation of dendritic cell apoptotic process
GO_0032008	Biological process	positive regulation of TOR signaling
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0070588	Biological process	calcium ion transmembrane transport
GO_2000533	Biological process	negative regulation of renal albumin absorption
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005796	Cellular component	Golgi lumen
GO_0070062	Cellular component	extracellular exosome
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0031093	Cellular component	platelet alpha granule lumen
GO_0005737	Cellular component	cytoplasm
GO_0043027	Molecular function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0048018	Molecular function	receptor ligand activity
GO_0005102	Molecular function	signaling receptor binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0030971	Molecular function	receptor tyrosine kinase binding

IV. Literature review

[source]

Gene name	GAS6
Protein name	Growth arrest-specific protein 6 Growth arrest-specific protein 6 (GAS-6) (AXL receptor tyrosine kinase ligand)
Synonyms	AXLLG
Description	FUNCTION: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. .; FUNCTION: (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry . Plays a role in Dengue cell entry by apoptotic mimicry . Plays a role in Vaccinia virus cell entry by apoptotic mimicry . Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry . .
Accessions	Q14393 A0A0F6PYS3 ENST00000327773.7 [Q14393-2]

GAS6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review