TNFSF11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFSF11 at tissue level.

III. Associated gene sets

GO_0055074Biological processcalcium ion homeostasis
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0007254Biological processJNK cascade
GO_0050870Biological processpositive regulation of T cell activation
GO_0051466Biological processpositive regulation of corticotropin-releasing hormone secretion
GO_0019722Biological processcalcium-mediated signaling
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0030316Biological processosteoclast differentiation
GO_0033598Biological processmammary gland epithelial cell proliferation
GO_0046330Biological processpositive regulation of JNK cascade
GO_0010628Biological processpositive regulation of gene expression
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0038001Biological processparacrine signaling
GO_1902533Biological processpositive regulation of intracellular signal transduction
GO_0060749Biological processmammary gland alveolus development
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0006955Biological processimmune response
GO_0044691Biological processtooth eruption
GO_0070371Biological processERK1 and ERK2 cascade
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0002158Biological processosteoclast proliferation
GO_0045453Biological processbone resorption
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0034112Biological processpositive regulation of homotypic cell-cell adhesion
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0071812Biological processpositive regulation of fever generation by positive regulation of prostaglandin secretion
GO_0001503Biological processossification
GO_0002548Biological processmonocyte chemotaxis
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_2001206Biological processpositive regulation of osteoclast development
GO_0045780Biological processpositive regulation of bone resorption
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0036035Biological processosteoclast development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0032813Molecular functiontumor necrosis factor receptor superfamily binding
GO_0042802Molecular functionidentical protein binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameTNFSF11
Protein nameTumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
Receptor activator of nuclear factor kappa B ligand 3 (Tumor necrosis factor (Ligand) superfamily, member 11, isoform CRA_b)
Tumor necrosis factor ligand superfamily member
SynonymsRANKL
OPGL
hRANKL
hCG_32838
3
TNLG6B
TRANCE
DescriptionFUNCTION: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy . Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity). .

AccessionsENST00000398795.7 [O14788-1]
Q54A98
O14788
Q5T9Y4
ENST00000358545.6 [O14788-2]