FGF21 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of FGF21 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FGF21 at tissue level.

III. Associated gene sets

GO_0071333Biological processcellular response to glucose stimulus
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0046326Biological processpositive regulation of glucose import
GO_1904640Biological processresponse to methionine
GO_0010898Biological processpositive regulation of triglyceride catabolic process
GO_0009887Biological processanimal organ morphogenesis
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0014823Biological processresponse to activity
GO_0010988Biological processregulation of low-density lipoprotein particle clearance
GO_0007267Biological processcell-cell signaling
GO_0072577Biological processendothelial cell apoptotic process
GO_0030968Biological processendoplasmic reticulum unfolded protein response
GO_0031667Biological processresponse to nutrient levels
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_0030154Biological processcell differentiation
GO_0030334Biological processregulation of cell migration
GO_0071377Biological processcellular response to glucagon stimulus
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0090080Biological processpositive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1905599Biological processpositive regulation of low-density lipoprotein receptor activity
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0008083Molecular functiongrowth factor activity
GO_0005104Molecular functionfibroblast growth factor receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFGF21
Protein nameFibroblast growth factor 21 (FGF-21)
SynonymsUNQ3115/PRO10196
DescriptionFUNCTION: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin sensitivity. .

AccessionsENST00000593756.6
ENST00000222157.5
Q9NSA1