NTRK3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
smooth muscle cell	20 studies	39% ± 20%	Explore
astrocyte	18 studies	53% ± 20%	Explore
oligodendrocyte precursor cell	15 studies	66% ± 18%	Explore
glutamatergic neuron	12 studies	67% ± 18%	Explore
GABAergic neuron	11 studies	52% ± 27%	Explore
pericyte	10 studies	28% ± 13%	Explore
retinal ganglion cell	7 studies	45% ± 15%	Explore
endothelial cell	6 studies	43% ± 16%	Explore
neuron	5 studies	41% ± 11%	Explore
amacrine cell	4 studies	38% ± 16%	Explore
granule cell	4 studies	63% ± 18%	Explore
interneuron	4 studies	62% ± 24%	Explore
GABAergic interneuron	3 studies	49% ± 21%	Explore
microglial cell	3 studies	56% ± 13%	Explore
GABAergic amacrine cell	3 studies	34% ± 8%	Explore
ON-bipolar cell	3 studies	37% ± 6%	Explore
glycinergic amacrine cell	3 studies	23% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	44% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	98%	6161.52	2590 / 2642	99%	14.90	700 / 705
breast	82%	2143.38	376 / 459	27%	1.15	300 / 1118
prostate	89%	2362.49	219 / 245	14%	0.24	71 / 502
blood vessel	100%	15803.55	1332 / 1335	0%	0	0 / 0
uterus	94%	3321.43	160 / 170	5%	0.24	22 / 459
bladder	71%	2234.81	15 / 21	1%	0.04	5 / 504
lung	68%	1250.37	395 / 578	3%	0.10	35 / 1155
adipose	70%	2387.40	847 / 1204	0%	0	0 / 0
thymus	26%	508.73	173 / 653	39%	1.22	238 / 605
kidney	44%	930.40	39 / 89	20%	0.47	183 / 901
ovary	40%	1680.71	72 / 180	9%	0.25	37 / 430
adrenal gland	16%	264.49	41 / 258	32%	2.12	73 / 230
skin	34%	634.85	607 / 1809	3%	0.18	15 / 472
heart	32%	497.58	275 / 861	0%	0	0 / 0
intestine	31%	555.58	296 / 966	1%	0.05	6 / 527
stomach	20%	408.70	71 / 359	2%	0.07	7 / 286
spleen	20%	272.45	48 / 241	0%	0	0 / 0
esophagus	16%	362.95	232 / 1445	2%	0.08	4 / 183
pancreas	1%	13.14	3 / 328	7%	0.10	12 / 178
muscle	6%	107.02	46 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.24	1 / 45
liver	0%	4.00	1 / 226	1%	0.02	4 / 406
eye	0%	0	0 / 0	1%	0.03	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032148	Biological process	activation of protein kinase B activity
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0010976	Biological process	positive regulation of neuron projection development
GO_0007507	Biological process	heart development
GO_0090630	Biological process	activation of GTPase activity
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_0010628	Biological process	positive regulation of gene expression
GO_0007275	Biological process	multicellular organism development
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0033674	Biological process	positive regulation of kinase activity
GO_0001933	Biological process	negative regulation of protein phosphorylation
GO_0030335	Biological process	positive regulation of cell migration
GO_0030154	Biological process	cell differentiation
GO_1990090	Biological process	cellular response to nerve growth factor stimulus
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0038179	Biological process	neurotrophin signaling pathway
GO_0050927	Biological process	positive regulation of positive chemotaxis
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0007399	Biological process	nervous system development
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0030424	Cellular component	axon
GO_0005030	Molecular function	neurotrophin receptor activity
GO_0004714	Molecular function	transmembrane receptor protein tyrosine kinase activity
GO_0043121	Molecular function	neurotrophin binding
GO_0002039	Molecular function	p53 binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NTRK3
Protein name	NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase) Neurotrophic tyrosine kinase receptor type 3 isoform A Neurotrophin 3 receptor truncated isoform Neurotrophin 3 receptor Neurotrophic tyrosine kinase, receptor, type 3 Tyrosine-protein kinase receptor (EC 2.7.10.1) Neurotrophic receptor tyrosine kinase 3
Synonyms	hCG_26627 TRKC
Description	FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. .
Accessions	ENST00000542733.6 Q96CY4 ENST00000557856.5 [Q16288-5] R4GN40 O95192 H0YM90 B7Z7U4 A0A087WX31 ENST00000558306.1 X5D7M5 ENST00000695462.1 [Q16288-1] ENST00000317501.9 [Q16288-2] ENST00000695463.1 A0A8Q3SHY2 ENST00000357724.6 [Q16288-4] X5D2R1 ENST00000629765.3 [Q16288-1] X5DNW6 Q16288 ENST00000558676.5 R4GNH5 ENST00000626019.2 ENST00000394480.6 [Q16288-3] A0A0D9SFP6 ENST00000560017.1 ENST00000559188.1 R4GMR8 ENST00000558576.5 O95193 X5DP84

NTRK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review