ALKAL2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ALKAL2 at tissue level.

III. Associated gene sets

GO_0070378Biological processpositive regulation of ERK5 cascade
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0010976Biological processpositive regulation of neuron projection development
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0030298Molecular functionreceptor signaling protein tyrosine kinase activator activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0030297Molecular functiontransmembrane receptor protein tyrosine kinase activator activity
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameALKAL2
Protein nameALK and LTK ligand 2
ALK and LTK ligand 2 (Augmentor alpha) (AUG-alpha)
SynonymsUNQ542/PRO1097
FAM150B
DescriptionFUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation . Cytokine-binding is sufficient to activate LTK . In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK . Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure . .

AccessionsQ6UX46
B5MCG6
H0Y3U4
ENST00000405290.5
ENST00000401489.6
ENST00000344414.9
ENST00000452023.1
B5MC33
ENST00000401503.5
A0A0B4J1W8
ENST00000403610.9 [Q6UX46-1]