Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 18 studies | 29% ± 12% | |
| smooth muscle cell | 13 studies | 26% ± 9% | |
| type I pneumocyte | 7 studies | 29% ± 9% | |
| platelet | 5 studies | 29% ± 6% | |
| epithelial cell | 5 studies | 32% ± 14% | |
| endothelial cell of lymphatic vessel | 4 studies | 22% ± 7% | |
| basal cell | 3 studies | 18% ± 1% | |
| glial cell | 3 studies | 21% ± 2% | |
| glutamatergic neuron | 3 studies | 27% ± 9% | |
| oligodendrocyte | 3 studies | 28% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 22% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 2595.28 | 245 / 245 | 100% | 40.12 | 501 / 502 |
| pancreas | 100% | 3821.99 | 328 / 328 | 99% | 34.90 | 177 / 178 |
| brain | 99% | 1761.32 | 2616 / 2642 | 98% | 40.86 | 691 / 705 |
| stomach | 100% | 2377.56 | 359 / 359 | 97% | 26.39 | 276 / 286 |
| kidney | 100% | 1687.66 | 89 / 89 | 95% | 47.04 | 858 / 901 |
| intestine | 100% | 2595.67 | 965 / 966 | 95% | 24.22 | 502 / 527 |
| lung | 100% | 2572.64 | 576 / 578 | 92% | 28.65 | 1065 / 1155 |
| breast | 98% | 1991.01 | 448 / 459 | 92% | 15.66 | 1030 / 1118 |
| bladder | 100% | 1879.43 | 21 / 21 | 89% | 20.80 | 449 / 504 |
| thymus | 98% | 1136.90 | 641 / 653 | 90% | 20.41 | 544 / 605 |
| esophagus | 95% | 2420.11 | 1374 / 1445 | 92% | 25.86 | 169 / 183 |
| uterus | 99% | 2279.28 | 169 / 170 | 87% | 21.76 | 399 / 459 |
| adrenal gland | 92% | 829.64 | 237 / 258 | 73% | 14.15 | 167 / 230 |
| skin | 77% | 905.81 | 1401 / 1809 | 72% | 36.45 | 342 / 472 |
| ovary | 58% | 712.02 | 105 / 180 | 70% | 10.66 | 299 / 430 |
| liver | 32% | 323.24 | 72 / 226 | 81% | 21.32 | 327 / 406 |
| spleen | 100% | 1814.39 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 11.63 | 1 / 1 |
| blood vessel | 100% | 7643.50 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1574.45 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 27.12 | 77 / 80 |
| muscle | 96% | 1379.50 | 767 / 803 | 0% | 0 | 0 / 0 |
| heart | 94% | 1279.84 | 809 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 67% | 12.82 | 30 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 38% | 5.22 | 11 / 29 |
| peripheral blood | 14% | 171.40 | 133 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001525 | Biological process | angiogenesis |
| GO_0010544 | Biological process | negative regulation of platelet activation |
| GO_0051781 | Biological process | positive regulation of cell division |
| GO_0060683 | Biological process | regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0010512 | Biological process | negative regulation of phosphatidylinositol biosynthetic process |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_1990401 | Biological process | embryonic lung development |
| GO_0035790 | Biological process | platelet-derived growth factor receptor-alpha signaling pathway |
| GO_0030031 | Biological process | cell projection assembly |
| GO_0072124 | Biological process | regulation of glomerular mesangial cell proliferation |
| GO_0043410 | Biological process | positive regulation of MAPK cascade |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0014910 | Biological process | regulation of smooth muscle cell migration |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0042060 | Biological process | wound healing |
| GO_0035793 | Biological process | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
| GO_0043406 | Biological process | positive regulation of MAP kinase activity |
| GO_0050730 | Biological process | regulation of peptidyl-tyrosine phosphorylation |
| GO_0002053 | Biological process | positive regulation of mesenchymal cell proliferation |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_0001775 | Biological process | cell activation |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0001942 | Biological process | hair follicle development |
| GO_2000278 | Biological process | regulation of DNA biosynthetic process |
| GO_0031954 | Biological process | positive regulation of protein autophosphorylation |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0043588 | Biological process | skin development |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0009611 | Biological process | response to wounding |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0048286 | Biological process | lung alveolus development |
| GO_0005902 | Cellular component | microvillus |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005796 | Cellular component | Golgi lumen |
| GO_1990265 | Cellular component | platelet-derived growth factor complex |
| GO_0009986 | Cellular component | cell surface |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0031093 | Cellular component | platelet alpha granule lumen |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
| GO_0008083 | Molecular function | growth factor activity |
| GO_0048407 | Molecular function | platelet-derived growth factor binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0005518 | Molecular function | collagen binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PDGFA |
| Protein name | Platelet-derived growth factor subunit A (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) Platelet-derived growth factor subunit A (PDGF subunit A) (PDGF-1) (Platelet-derived growth factor A chain) (Platelet-derived growth factor alpha polypeptide) Platelet derived growth factor subunit A Platelet-derived growth factor A chain |
| Synonyms | PDGF1 |
| Description | FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). . FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. . FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. . |
| Accessions | ENST00000405692.2 A0A0A0MSC4 P04085 Q9UGN0 ENST00000400761.7 ENST00000402802.8 [P04085-2] Q32M96 H7BYW6 ENST00000354513.9 [P04085-1] |
