CXCL17 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090026Biological processpositive regulation of monocyte chemotaxis
GO_0001525Biological processangiogenesis
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0050728Biological processnegative regulation of inflammatory response
GO_0030154Biological processcell differentiation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0010575Biological processpositive regulation of vascular endothelial growth factor production
GO_0048246Biological processmacrophage chemotaxis
GO_0005615Cellular componentextracellular space
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCXCL17
Protein nameC-X-C motif chemokine 17 (6-Cys CXCL17) (Dendritic cell and monocyte chemokine-like protein) (DMC) (VEGF coregulated chemokine 1) [Cleaved into: 4-Cys CXCL17]
C-X-C motif chemokine ligand 17
SynonymsVCC1
UNQ473/PRO842
DescriptionFUNCTION: Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells . Plays a role in angiogenesis and possibly in the development of tumors . Acts as an anti-inflammatory in the stomach . May play a role in the innate defense against infections . Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions . .; FUNCTION: [4-Cys CXCL17]: Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. .

AccessionsENST00000601181.6
Q6UXB2
ENST00000341918.4
X6R584