Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| fibroblast | 10 studies | 19% ± 2% | |
| astrocyte | 9 studies | 27% ± 10% | |
| oligodendrocyte precursor cell | 5 studies | 23% ± 6% | |
| pericyte | 4 studies | 23% ± 4% | |
| smooth muscle cell | 3 studies | 17% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 27% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 3572.71 | 2622 / 2642 | 99% | 89.26 | 701 / 705 |
| intestine | 100% | 3623.05 | 964 / 966 | 97% | 69.26 | 513 / 527 |
| skin | 99% | 2737.08 | 1799 / 1809 | 98% | 134.47 | 461 / 472 |
| stomach | 97% | 2157.08 | 349 / 359 | 97% | 51.98 | 278 / 286 |
| lung | 99% | 3338.13 | 572 / 578 | 91% | 32.14 | 1055 / 1155 |
| thymus | 100% | 2956.17 | 650 / 653 | 89% | 26.04 | 538 / 605 |
| prostate | 100% | 2784.71 | 244 / 245 | 87% | 17.45 | 437 / 502 |
| pancreas | 89% | 1229.65 | 292 / 328 | 94% | 35.79 | 168 / 178 |
| esophagus | 97% | 2897.33 | 1405 / 1445 | 83% | 25.38 | 151 / 183 |
| adrenal gland | 99% | 1866.98 | 256 / 258 | 78% | 24.86 | 179 / 230 |
| kidney | 91% | 1486.22 | 81 / 89 | 81% | 25.22 | 729 / 901 |
| ovary | 94% | 1612.78 | 170 / 180 | 77% | 31.61 | 329 / 430 |
| bladder | 100% | 2771.00 | 21 / 21 | 69% | 29.35 | 348 / 504 |
| uterus | 99% | 3084.86 | 169 / 170 | 66% | 26.60 | 304 / 459 |
| breast | 100% | 6931.45 | 459 / 459 | 54% | 11.74 | 602 / 1118 |
| liver | 92% | 1299.40 | 209 / 226 | 50% | 9.51 | 205 / 406 |
| adipose | 100% | 6944.49 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2895.42 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3861.94 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 2824.05 | 859 / 861 | 0% | 0 | 0 / 0 |
| muscle | 99% | 2222.59 | 797 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 31.64 | 76 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 11.23 | 27 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 3.21 | 5 / 29 |
| peripheral blood | 6% | 77.48 | 52 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007605 | Biological process | sensory perception of sound |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO_0060449 | Biological process | bud elongation involved in lung branching |
| GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_0000132 | Biological process | establishment of mitotic spindle orientation |
| GO_0046580 | Biological process | negative regulation of Ras protein signal transduction |
| GO_0048513 | Biological process | animal organ development |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0031345 | Biological process | negative regulation of cell projection organization |
| GO_0010801 | Biological process | negative regulation of peptidyl-threonine phosphorylation |
| GO_0060437 | Biological process | lung growth |
| GO_1902747 | Biological process | negative regulation of lens fiber cell differentiation |
| GO_0045742 | Biological process | positive regulation of epidermal growth factor receptor signaling pathway |
| GO_0031397 | Biological process | negative regulation of protein ubiquitination |
| GO_0070371 | Biological process | ERK1 and ERK2 cascade |
| GO_0045165 | Biological process | cell fate commitment |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0010719 | Biological process | negative regulation of epithelial to mesenchymal transition |
| GO_1900747 | Biological process | negative regulation of vascular endothelial growth factor signaling pathway |
| GO_0042472 | Biological process | inner ear morphogenesis |
| GO_0043407 | Biological process | negative regulation of MAP kinase activity |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_0035924 | Biological process | cellular response to vascular endothelial growth factor stimulus |
| GO_0051387 | Biological process | negative regulation of neurotrophin TRK receptor signaling pathway |
| GO_0040037 | Biological process | negative regulation of fibroblast growth factor receptor signaling pathway |
| GO_0008543 | Biological process | fibroblast growth factor receptor signaling pathway |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_1990752 | Cellular component | microtubule end |
| GO_0005634 | Cellular component | nucleus |
| GO_0055105 | Molecular function | ubiquitin-protein transferase inhibitor activity |
| GO_0030291 | Molecular function | protein serine/threonine kinase inhibitor activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SPRY2 |
| Protein name | Protein sprouty homolog 2 (Spry-2) |
| Synonyms | |
| Description | FUNCTION: Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2 (By similarity). Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells (By similarity). Inhibits CBL/C-CBL-mediated EGFR ubiquitination . . |
| Accessions | O43597 ENST00000377102.5 ENST00000377104.4 |
