CFLAR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014732Biological processskeletal muscle atrophy
GO_0033574Biological processresponse to testosterone
GO_0030216Biological processkeratinocyte differentiation
GO_0097190Biological processapoptotic signaling pathway
GO_0072126Biological processpositive regulation of glomerular mesangial cell proliferation
GO_2000347Biological processpositive regulation of hepatocyte proliferation
GO_0007519Biological processskeletal muscle tissue development
GO_0071549Biological processcellular response to dexamethasone stimulus
GO_0032869Biological processcellular response to insulin stimulus
GO_0010976Biological processpositive regulation of neuron projection development
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0060544Biological processregulation of necroptotic process
GO_1903845Biological processnegative regulation of cellular response to transforming growth factor beta stimulus
GO_0071392Biological processcellular response to estradiol stimulus
GO_0043403Biological processskeletal muscle tissue regeneration
GO_0071732Biological processcellular response to nitric oxide
GO_1903944Biological processnegative regulation of hepatocyte apoptotic process
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_1903427Biological processnegative regulation of reactive oxygen species biosynthetic process
GO_0042060Biological processwound healing
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0030218Biological processerythrocyte differentiation
GO_0030182Biological processneuron differentiation
GO_1903055Biological processpositive regulation of extracellular matrix organization
GO_0014866Biological processskeletal myofibril assembly
GO_0043066Biological processnegative regulation of apoptotic process
GO_0014842Biological processregulation of skeletal muscle satellite cell proliferation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_1901740Biological processnegative regulation of myoblast fusion
GO_0006508Biological processproteolysis
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0010667Biological processnegative regulation of cardiac muscle cell apoptotic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0071456Biological processcellular response to hypoxia
GO_0097342Cellular componentripoptosome
GO_0031265Cellular componentCD95 death-inducing signaling complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031264Cellular componentdeath-inducing signaling complex
GO_0008047Molecular functionenzyme activator activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0002020Molecular functionprotease binding
GO_0097200Molecular functioncysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0097199Molecular functioncysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO_0005123Molecular functiondeath receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCFLAR
Protein nameCASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
CASP8 and FADD like apoptosis regulator
CASP8 and FADD-like apoptosis regulator, isoform CRA_a (Usurpin-beta splice variant)
SynonymsMRIT
CASP8AP1
CASH
hCG_16553
CLARP
DescriptionFUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. .

AccessionsENST00000341222.10 [O15519-2]
ENST00000470178.6
ENST00000457277.5 [O15519-11]
ENST00000395148.6
C9J408
O15519
ENST00000423241.6 [O15519-1]
C9J4Q0
M0QYM0
A0A336TY74
ENST00000494258.5
ENST00000342795.9 [O15519-12]
F8WBH9
ENST00000439154.6
ENST00000433445.1
C9JSU3
ENST00000417748.1
M0R1A8
ENST00000479953.6 [O15519-3]
E9PAP3
ENST00000441224.5
ENST00000341582.10 [O15519-8]
ENST00000309955.8 [O15519-1]
ENST00000425030.1
ENST00000440180.5 [O15519-2]
ENST00000462763.5
ENST00000443227.5 [O15519-15]
C9JV51
M0QY57