PDGFC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051781Biological processpositive regulation of cell division
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0009887Biological processanimal organ morphogenesis
GO_0043406Biological processpositive regulation of MAP kinase activity
GO_0048008Biological processplatelet-derived growth factor receptor signaling pathway
GO_0050730Biological processregulation of peptidyl-tyrosine phosphorylation
GO_0030335Biological processpositive regulation of cell migration
GO_0048144Biological processfibroblast proliferation
GO_0071230Biological processcellular response to amino acid stimulus
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0048565Biological processdigestive tract development
GO_0007417Biological processcentral nervous system development
GO_0031954Biological processpositive regulation of protein autophosphorylation
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0060348Biological processbone development
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0005161Molecular functionplatelet-derived growth factor receptor binding
GO_0008083Molecular functiongrowth factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDGFC
Protein namePlatelet derived growth factor C
Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]
SynonymsUNQ174/PRO200
SCDGF
DescriptionFUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. .

AccessionsJ3KN71
Q9NRA1
ENST00000502773.6 [Q9NRA1-1]
ENST00000422544.2 [Q9NRA1-2]
ENST00000274071.6
ENST00000506880.5
H0Y9N2