Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 12 studies | 43% ± 22% | |
oligodendrocyte precursor cell | 11 studies | 39% ± 15% | |
astrocyte | 11 studies | 35% ± 16% | |
smooth muscle cell | 9 studies | 26% ± 7% | |
adipocyte | 9 studies | 41% ± 10% | |
endothelial cell | 8 studies | 26% ± 9% | |
microglial cell | 8 studies | 27% ± 7% | |
myeloid cell | 6 studies | 35% ± 12% | |
glutamatergic neuron | 6 studies | 33% ± 19% | |
mesothelial cell | 5 studies | 26% ± 7% | |
endothelial cell of lymphatic vessel | 5 studies | 22% ± 7% | |
cholangiocyte | 4 studies | 57% ± 21% | |
GABAergic neuron | 4 studies | 29% ± 5% | |
myofibroblast cell | 4 studies | 22% ± 8% | |
cardiac muscle cell | 4 studies | 18% ± 2% | |
type II pneumocyte | 4 studies | 24% ± 3% | |
connective tissue cell | 3 studies | 26% ± 9% | |
epithelial cell | 3 studies | 24% ± 4% | |
hepatocyte | 3 studies | 43% ± 14% | |
retinal pigment epithelial cell | 3 studies | 29% ± 5% | |
fibroblast | 3 studies | 19% ± 2% | |
alveolar macrophage | 3 studies | 44% ± 2% | |
monocyte | 3 studies | 28% ± 5% | |
type I pneumocyte | 3 studies | 21% ± 5% | |
basal cell | 3 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 2491.36 | 180 / 180 | 98% | 22.69 | 423 / 430 |
kidney | 100% | 1316.51 | 89 / 89 | 98% | 25.71 | 880 / 901 |
thymus | 100% | 1144.92 | 650 / 653 | 98% | 31.51 | 593 / 605 |
breast | 100% | 1700.59 | 459 / 459 | 95% | 20.28 | 1060 / 1118 |
lung | 99% | 1153.40 | 572 / 578 | 93% | 19.02 | 1072 / 1155 |
prostate | 100% | 2211.91 | 245 / 245 | 91% | 14.33 | 459 / 502 |
pancreas | 97% | 967.17 | 318 / 328 | 91% | 31.35 | 162 / 178 |
uterus | 100% | 3539.52 | 170 / 170 | 75% | 17.57 | 343 / 459 |
brain | 73% | 404.29 | 1934 / 2642 | 99% | 20.32 | 695 / 705 |
stomach | 100% | 1024.73 | 358 / 359 | 71% | 8.09 | 202 / 286 |
esophagus | 92% | 1107.27 | 1334 / 1445 | 76% | 11.39 | 139 / 183 |
liver | 100% | 792.02 | 225 / 226 | 64% | 9.99 | 261 / 406 |
bladder | 100% | 1637.95 | 21 / 21 | 63% | 8.29 | 318 / 504 |
intestine | 98% | 1523.89 | 949 / 966 | 63% | 8.21 | 334 / 527 |
skin | 99% | 1884.31 | 1797 / 1809 | 38% | 5.62 | 178 / 472 |
adrenal gland | 100% | 2393.46 | 258 / 258 | 36% | 6.47 | 83 / 230 |
blood vessel | 100% | 3361.89 | 1335 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 1492.06 | 1202 / 1204 | 0% | 0 | 0 / 0 |
heart | 86% | 525.19 | 741 / 861 | 0% | 0 | 0 / 0 |
spleen | 84% | 593.08 | 202 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 69% | 6.57 | 31 / 45 |
muscle | 66% | 395.05 | 526 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 24% | 177.80 | 220 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 10% | 0.50 | 3 / 29 |
eye | 0% | 0 | 0 / 0 | 3% | 0.15 | 2 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0051781 | Biological process | positive regulation of cell division |
GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
GO_0009887 | Biological process | animal organ morphogenesis |
GO_0043406 | Biological process | positive regulation of MAP kinase activity |
GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
GO_0050730 | Biological process | regulation of peptidyl-tyrosine phosphorylation |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0048144 | Biological process | fibroblast proliferation |
GO_0071230 | Biological process | cellular response to amino acid stimulus |
GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
GO_0048565 | Biological process | digestive tract development |
GO_0007417 | Biological process | central nervous system development |
GO_0031954 | Biological process | positive regulation of protein autophosphorylation |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0060348 | Biological process | bone development |
GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0009986 | Cellular component | cell surface |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005788 | Cellular component | endoplasmic reticulum lumen |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
GO_0008083 | Molecular function | growth factor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | PDGFC |
Protein name | Platelet derived growth factor C Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)] |
Synonyms | UNQ174/PRO200 SCDGF |
Description | FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. . |
Accessions | J3KN71 Q9NRA1 ENST00000502773.6 [Q9NRA1-1] ENST00000422544.2 [Q9NRA1-2] ENST00000274071.6 ENST00000506880.5 H0Y9N2 |