NECAB2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NECAB2 at tissue level.

III. Associated gene sets

GO_0060168Biological processpositive regulation of adenosine receptor signaling pathway
GO_1905477Biological processpositive regulation of protein localization to membrane
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1900451Biological processpositive regulation of glutamate receptor signaling pathway
GO_1904021Biological processnegative regulation of G protein-coupled receptor internalization
GO_0042984Biological processregulation of amyloid precursor protein biosynthetic process
GO_0030424Cellular componentaxon
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0030425Cellular componentdendrite
GO_0031687Molecular functionA2A adenosine receptor binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0031802Molecular functiontype 5 metabotropic glutamate receptor binding

IV. Literature review

[source]
Gene nameNECAB2
Protein nameN-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) (Synaptotagmin-interacting protein 2) (Stip-2)
Alternative protein NECAB2
N-terminal EF-hand calcium binding protein 2
SynonymsEFCBP2
DescriptionFUNCTION: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. .

AccessionsENST00000305202.9 [Q7Z6G3-1]
ENST00000566836.1
ENST00000564166.1
Q7Z6G3
H3BPH6
H3BQC7
L8E8I4
ENST00000565691.5 [Q7Z6G3-2]