PDGFD | OmnibusX

Name	Number of supported studies	Average coverage
endothelial cell	10 studies	26% ± 10%	Explore
fibroblast	10 studies	34% ± 17%	Explore
natural killer cell	6 studies	28% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	4 studies	22% ± 11%	Explore
adipocyte	4 studies	20% ± 4%	Explore
cholangiocyte	3 studies	44% ± 19%	Explore
glomerular endothelial cell	3 studies	40% ± 0%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	30% ± 12%	Explore
mesothelial cell	3 studies	33% ± 13%	Explore
retina horizontal cell	3 studies	25% ± 8%	Explore
GABAergic neuron	3 studies	27% ± 8%	Explore
glutamatergic neuron	3 studies	30% ± 5%	Explore

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDGFD at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	13732.56	258 / 258	95%	41.65	218 / 230
pancreas	100%	1850.80	327 / 328	94%	27.70	167 / 178
breast	99%	3090.91	456 / 459	92%	20.67	1031 / 1118
thymus	100%	3700.11	652 / 653	91%	22.12	551 / 605
prostate	85%	1116.40	208 / 245	86%	10.70	431 / 502
ovary	100%	7281.01	180 / 180	69%	8.54	297 / 430
kidney	69%	664.71	61 / 89	93%	56.97	834 / 901
stomach	95%	1487.64	340 / 359	61%	6.69	174 / 286
skin	71%	1536.25	1289 / 1809	70%	18.26	330 / 472
bladder	76%	1663.95	16 / 21	50%	5.50	252 / 504
uterus	84%	1408.76	142 / 170	42%	5.38	191 / 459
intestine	63%	651.86	605 / 966	48%	5.26	253 / 527
blood vessel	100%	6951.74	1329 / 1335	0%	0	0 / 0
adipose	99%	3394.57	1194 / 1204	0%	0	0 / 0
heart	96%	2025.34	826 / 861	0%	0	0 / 0
lung	35%	308.64	200 / 578	57%	6.72	660 / 1155
esophagus	28%	338.92	409 / 1445	49%	5.08	89 / 183
lymph node	0%	0	0 / 0	69%	17.67	20 / 29
liver	2%	16.99	4 / 226	48%	15.25	195 / 406
brain	4%	35.68	117 / 2642	43%	6.14	301 / 705
eye	0%	0	0 / 0	35%	4.36	28 / 80
tonsil	0%	0	0 / 0	16%	1.05	7 / 45
spleen	14%	90.66	34 / 241	0%	0	0 / 0
peripheral blood	13%	112.03	118 / 929	0%	0	0 / 0
muscle	6%	49.00	50 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0051781	Biological process	positive regulation of cell division
GO_0071673	Biological process	positive regulation of smooth muscle cell chemotaxis
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0072126	Biological process	positive regulation of glomerular mesangial cell proliferation
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0043406	Biological process	positive regulation of MAP kinase activity
GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_2000439	Biological process	positive regulation of monocyte extravasation
GO_0050730	Biological process	regulation of peptidyl-tyrosine phosphorylation
GO_0030335	Biological process	positive regulation of cell migration
GO_0071230	Biological process	cellular response to amino acid stimulus
GO_0031954	Biological process	positive regulation of protein autophosphorylation
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_0036120	Biological process	cellular response to platelet-derived growth factor stimulus
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0000139	Cellular component	Golgi membrane
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005161	Molecular function	platelet-derived growth factor receptor binding
GO_0008083	Molecular function	growth factor activity

IV. Literature review

[source]

Gene name	PDGFD
Protein name	Platelet derived growth factor D Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)]
Synonyms	IEGF UNQ1899/PRO4345 MSTP036 SCDGFB
Description	FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). .
Accessions	ENST00000529268.1 H0YD37 ENST00000302251.9 [Q9GZP0-2] Q9GZP0 ENST00000393158.7 [Q9GZP0-1]

PDGFD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review